Abstract
Topical application of eye drops, ointments, gels, or emulsions to treat ocular anterior segment diseases is preferred due to the ease of administration and low cost. Preservatives are the most important ingredients in ocular formulations next to active ingredient. These are often included to prevent the chances of inadvertent contamination of the ocular formulations preserved in multidose containers, most frequently during opening and application to the infected eyes. Indeed preservatives that kill or damage growing microbial cells may also be toxic to growing cells of the ocular tissues. Clinical studies suggest that the long-term use of ophthalmic preparations for effective therapy may induce major and frequent ocular surface changes causing allergic or inflammatory reactions such as redness, stinging, burning, irritation, eye dryness, or less frequently conjunctivitis or corneal damage. With the aging of population, the need for treatments of ocular diseases has become more important than ever. Increasingly high incidences of ocular disorders demand better, more effective, and innovative treatments without appreciable toxic manifestations because the preservation of vision is critical for improving the quality of life. This chapter addresses various commonly used ocular preservatives along with their ocular toxicity, newer preservatives, or other options coming up in this arena.
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Maiti, S., Sadhukhan, S., Bakshi, P. (2016). Ocular Preservatives: Risks and Recent Trends in Its Application in Ocular Drug Delivery (ODD). In: Pathak, Y., Sutariya, V., Hirani, A. (eds) Nano-Biomaterials For Ophthalmic Drug Delivery. Springer, Cham. https://doi.org/10.1007/978-3-319-29346-2_13
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DOI: https://doi.org/10.1007/978-3-319-29346-2_13
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