Abstract
Surface biofunctionalization techniques are essential resources for improving the biological and biochemical response of several biomedical devices and provide the opportunity of interacting with cells, even at a molecular level, by means of controlling matter in the range of nanometers. Applications of nanomanufacturing technologies, in many cases applied as post-processes, include: the improvement of biocompatibility, the promotion of wear resistance, the incorporation of special tribological (contact) phenomena linked to controlling adhesion, wettability or friction, the incorporation of anti-bacterial properties and the overall improvement of (bio)mechanical properties and aesthetics, among others. This chapter provides an overview of the more relevant nanomanufacturing technologies with special application to the development of advanced micro-medical devices with surface biofunctionalizations for optimal performance, as several of these manufacturing technologies will be applied thoroughly along the Handbook for the development of different cases of study. The different technologies detailed in present chapter are also illustrated by means of different application examples related to enhancing the biological response of different cell culture platforms and tissue engineering scaffolds aimed at interacting at a cellular level. The possibility of combining technologies for the promotion of multi-scale and biomimetic approaches is also analyzed in detail and some current research challenges are also discussed.
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Díaz Lantada, A., Endrino, J.L. (2016). Nanomanufacturing Technologies for Biomedical Microsystems Interacting at a Molecular Scale. In: Díaz Lantada, A. (eds) Microsystems for Enhanced Control of Cell Behavior. Studies in Mechanobiology, Tissue Engineering and Biomaterials, vol 18. Springer, Cham. https://doi.org/10.1007/978-3-319-29328-8_9
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DOI: https://doi.org/10.1007/978-3-319-29328-8_9
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