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Rapid Prototyping of Biomedical Microsystems for Interacting at a Cellular Level

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Microsystems for Enhanced Control of Cell Behavior

Part of the book series: Studies in Mechanobiology, Tissue Engineering and Biomaterials ((SMTEB,volume 18))

Abstract

The applications of microsystems in the biomedical field are indeed remarkable and continuously evolving thanks to recent extraordinary progresses in the area of micromanufacturing technologies, capable of manufacturing devices with details in the typical range of 1–500 μm. As living organisms are made up with cells, whose overall dimensions typically range from 5 to 100 μm, micro-manufactured devices (with details precisely in that range) are very well-suited to interacting at a cellular level for promoting innovative diagnostic and therapeutic approaches. This chapter provides an overview of the more relevant micromanufacturing technologies with special application to the development of advanced micro-medical devices and to the manufacture of rapid prototypes, as several of these manufacturing technologies will be applied thoroughly along the Handbook for the development of different cases of study linked to microfluidic biodevices for disease modeling, to cell culture platforms for understanding cell behavior, to labs-on-chips and organs-on-chips and to tissue engineering scaffolds. The different technologies detailed in present chapter are also illustrated by means of application examples related to the aforementioned types of biomedical microdevices aimed at interacting at a cellular level. The possibility of combining technologies for the promotion of multi-scale and biomimetic approaches is also analyzed in detail and some current research challenges are also discussed.

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Acknowledgements

We gratefully acknowledge the support of the Karlsruhe Nano Micro Facility (KNMF, http://www.knmf.kit.edu/) a Helmholtz research infrastructure at the Karlsruhe Institute of Technology (KIT). Proposal KNMF-2013-010001542 (muFractal: Microsystem for studying the influence of fractal dimension on cell behaviour), linked to the rapid manufacture of microtextured microsystems, proposal KNMF-2013-010001541 (NanoAUX: Additive nanomanufacture of 3D auxetic metamaterials), linked to the nano-manufacture of auxetic metamaterials, and proposal KNMF-2012-009001145 (Replic-AS: Replication of advanced scaffolds with biomimetric fractal features), linked to replicating the presented multi-channelled microsystem with fractal channels, and the co-authors and their teams that made them possible are acknowledged. We acknowledge the support of the “Tomax: Tool-less manufacture of complex geometries” project, funded by the European Union Commission under grant nº: 633192 - H2020-FoF-2014-2015/H2020-FoF-2014 and led by Prof. Dr. Jürgen Stampfl from the Technical University of Vienna.

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Authors and Affiliations

  1. Mechanical Engineering Department – Product Development Laboratory, Universidad Politécnica de Madrid, c/José Gutiérrez Abascal 2, 28006, Madrid, Spain

    Andrés Díaz Lantada, Jeffrey Resnick, Javier Mousa & Miguel Ángel de Alba

  2. Institute of Microstructure Technology, Karlsruhe Institute of Technology, Hermann von Helmholtz Platz 1, Eggenstein-Leopoldshafen, Germany

    Stefan Hengsbach

  3. Centre for Biomedical Technology, Universidad Politécnica de Madrid UPM Scientific and Technological Park, Montegancedo Campus, Crta. M40 - km 38, 28223, Pozuelo de Alarcón, Spain

    Milagros Ramos Gómez

Authors
  1. Andrés Díaz Lantada
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  2. Jeffrey Resnick
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  3. Javier Mousa
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  4. Miguel Ángel de Alba
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  5. Stefan Hengsbach
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  6. Milagros Ramos Gómez
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Correspondence to Andrés Díaz Lantada .

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  1. Mechanical Engineering, Universidad Politecnica de Madrid, Madrid, Spain

    Andrés Díaz Lantada

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Díaz Lantada, A., Resnick, J., Mousa, J., de Alba, M.Á., Hengsbach, S., Ramos Gómez, M. (2016). Rapid Prototyping of Biomedical Microsystems for Interacting at a Cellular Level. In: Díaz Lantada, A. (eds) Microsystems for Enhanced Control of Cell Behavior. Studies in Mechanobiology, Tissue Engineering and Biomaterials, vol 18. Springer, Cham. https://doi.org/10.1007/978-3-319-29328-8_8

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  • DOI: https://doi.org/10.1007/978-3-319-29328-8_8

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  • Online ISBN: 978-3-319-29328-8

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