Skip to main content

Part of the book series: Current Clinical Psychiatry ((CCPSY))

  • 1172 Accesses

Abstract

Though Human Immunodeficiency Virus (HIV) continues to spread around the world, advancements in antiretroviral therapy (ART) have made long-term management of the disease possible, as well as significantly reduced the risk of spreading the virus to others. However, common psychiatric/psychological conditions among HIV-infected individuals can have a detrimental impact when it comes to self-care related to the disease (i.e., medication adherence and sexual health). Furthermore, cognitive behavioral therapy (CBT) has been shown to be effective in treating these mental health conditions in the context of HIV self-care. In the first half of this chapter, we discuss the existing literature on common psychological conditions that impact individuals living with HIV, the role of these conditions in negatively affecting self-care, and the efficacy of CBT when it comes to ameliorating these psychosocial issues. We highlight depression and PTSD as key comorbid psychological conditions among this population, both of which have been linked to poor medication adherence and risky sexual behavior. In addition, we discuss the importance of targeting these areas of psychopathology in the context of HIV self-care, which research has shown can improve medication adherence and sexual risk above and beyond traditional interventions that do not address psychological comorbidities. In the second half of this chapter, we elaborate on a CBT intervention for HIV medication adherence and depression. We also include case examples throughout our discussion of the intervention to demonstrate practical applications of CBT. Finally, we end the chapter by discussing future research directions that target co-occurring psychological and health conditions for individuals living with HIV. These include the augmentation of existing CBT interventions, the dissemination of empirically based clinical tools, the use of technology to make CBT interventions easily accessible, and the integration of psychological and biomedical prevention strategies.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 59.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 79.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Abbreviations

ART:

Antiretroviral therapy

CBO:

Community-based organizations

CBT:

Cognitive behavioral therapy

CBT-AD:

Cognitive behavioral therapy for HIV medication adherence and depression

ETAU:

Enhanced treatment as usual

MSM:

Men who have sex with men

PEP:

Post-exposure prophylaxis

PREP:

Pre-exposure prophylaxis

PTSD:

Posttraumatic stress disorder

RCT:

Randomized control trial

UAI:

Unprotected anal intercourse

References

  1. CDC. Monitoring selected national HIV prevention and care objectives by using HIV surveillance data—United States and 6 dependent areas—2012. HIV Surveil Suppl Rep. 2014;19(3):1–61.

    Google Scholar 

  2. CDC. Estimated HIV incidence in the United States, 2007–2010. HIV Surveil Suppl Rep. 2012;17(4):1–26.

    Google Scholar 

  3. CDC. HIV surveillance—epidemiology of HIV infection (through 2011). 2013. http://www.cdc.gov/hiv/topics/surveillance/resources/slides/general/index.htm. Accessed Apr 2015.

  4. Cohen MS, McCauley M, Gamble TR. HIV treatment as prevention and HPTN 052. Curr Opin HIV AIDS. 2012;7(2):99–105.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Rodger A, Bruun T, Weait M, Vernazza P, Collins S, Estrada V, et al. Partners of people on ART—a new evaluation of the risks (The PARTNER study): design and methods. BMC Public Health. 2012;12:296.

    Article  PubMed  PubMed Central  Google Scholar 

  6. Blashill AJ, Gordon JR, Mimiaga MJ, Safren SA. HIV/AIDS and depression. In: Richards CS, O’Hara MW, editors. The Oxford handbook of depression and comorbidity. New York: Oxford University Press; 2014.

    Google Scholar 

  7. Blashill AJ, Perry N, Safren SA. Mental health: a focus on stress, coping, and mental illness as it relates to treatment retention, adherence, and other health outcomes. Curr HIV/AIDS Rep. 2011;8(4):215–22.

    Article  PubMed  PubMed Central  Google Scholar 

  8. Boarts JM, Sledjeski EM, Bogart LM, Delahanty DL. The differential impact of PTSD and depression on HIV disease markers and adherence to HAART in people living with HIV. AIDS Behav. 2006;10(3):253–61.

    Article  PubMed  Google Scholar 

  9. Bing EG, Burnam MA, Longshore D, Fleishman JA, Sherbourne CD, London AS, et al. Psychiatric disorders and drug use among human immunodeficiency virus-infected adults in the United States. Arch Gen Psychiatry. 2001;58(8):721–8.

    Article  CAS  PubMed  Google Scholar 

  10. Ciesla JA, Roberts JE. Meta-analysis of the relationship between HIV infection and risk for depressive disorders. Am J Psychiatry. 2001;158(5):725–30.

    Article  CAS  PubMed  Google Scholar 

  11. Eller LS, Bunch EH, Wantland DJ, Portillo CJ, Reynolds NR, Nokes KM, et al. Prevalence, correlates, and self-management of HIV-related depressive symptoms. AIDS Care. 2010;22(9):1159–70.

    Article  CAS  PubMed  Google Scholar 

  12. Gonzalez JS, Batchelder AW, Psaros C, Safren SA. Depression and HIV/AIDS treatment nonadherence: a review and meta-analysis. J Acquir Immune Defic Syndr. 2011;58(2):181–7.

    Article  PubMed  Google Scholar 

  13. Safren SA, O’Cleirigh CM, Bullis JR, Otto MW, Stein MD, Pollack MH. Cognitive behavioral therapy for adherence and depression (CBT-AD) in HIV-infected injection drug users: a randomized controlled trial. J Consult Clin Psychol. 2012;80(3):404–15.

    Article  PubMed  PubMed Central  Google Scholar 

  14. Cohen MS, Deamant C, Barkan S, Richardson J, Young M, Holman S, et al. Domestic violence and childhood sexual abuse in HIV-infected women and women at risk for HIV. Am J Public Health. 2000;90(4):560–5.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Machtinger EL, Wilson TC, Haberer JE, Weiss DS. Psychological trauma and PTSD in HIV-positive women: a meta-analysis. AIDS Behav. 2012;16(8):2091–100.

    Article  CAS  PubMed  Google Scholar 

  16. Reisner SL, Falb KL, Mimiaga MJ. Early life traumatic stressors and the mediating role of PTSD in incident HIV infection among US men, comparisons by sexual orientation and race/ethnicity: results from the NESARC, 2004–2005. J Acquir Immune Defic Syndr. 2011;57(4):340–50.

    Article  PubMed  Google Scholar 

  17. Panel on Antiretroviral Agents in HIV-Infected Adults and Adolescents. Guidelines for the use of antiretroviral agents in HIV-1 infected adults and adolescents. Department of Health and Human Services. 2009. http://aidsinfo.nih.gov/content-files/adultadolescentGL.pdf. Accessed April 2015.

  18. Bangsberg DR, Ragland K, Monk A, Deeks SG. A single tablet regimen is associated with higher adherence and viral suppression than multiple tablet regimens in HIV+ homeless and marginally housed people. AIDS. 2010;24(18):2835–40.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  19. Nachega JB, Parienti J-J, Uthman OA, Gross R, Dowdy DW, Sax PE, et al. Lower pill burden and once-daily antiretroviral treatment regimens for HIV infection: a meta-analysis of randomized controlled trials. Clin Infect Dis. 2014;58(9):1297–307.

    Article  PubMed  PubMed Central  Google Scholar 

  20. Cohen CJ, Meyers JL, Davis KL. Association between daily antiretroviral pill burden and treatment adherence, hospitalisation risk, and other healthcare utilisation and costs in a US medicaid population with HIV. BMJ Open. 2013;3(8):e003028.

    Article  PubMed  PubMed Central  Google Scholar 

  21. Dejesus E, Young B, Morales-Ramirez JO, Sloan L, Ward DJ, Flaherty JF, et al. Simplification of antiretroviral therapy to a single-tablet regimen consisting of efavirenz, emtricitabine, and tenofovir disoproxil fumarate versus unmodified antiretroviral therapy in virologically suppressed HIV-1-infected patients. J Acquir Immune Defic Syndr. 2009;51(2):163–74.

    Article  CAS  PubMed  Google Scholar 

  22. Hodder SL, Mounzer K, Dejesus E, Ebrahimi R, Grimm K, Esker S, et al. Patient-reported outcomes in virologically suppressed, HIV-1-Infected subjects after switching to a simplified, single-tablet regimen of efavirenz, emtricitabine, and tenofovir DF. AIDS Patient Care STDS. 2010;24(2):87–96.

    Article  PubMed  Google Scholar 

  23. Arnsten JH, Demas PA, Farzadegan H, Grant RW, Gourevitch MN, Chang C-J, et al. Antiretroviral therapy adherence and viral suppression in HIV-Infected drug users: comparison of self-report and electronic monitoring. Clin Infect Dis. 2001;33(8):1417–23.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  24. Ramratnam B, Mittler JE, Zhang L, Boden D, Hurley A, Fang F, et al. The decay of the latent reservoir of replication-competent HIV-1 is inversely correlated with the extent of residual viral replication during prolonged anti-retroviral therapy. Nat Med. 2000;6(1):82–5.

    Article  CAS  PubMed  Google Scholar 

  25. Hunt PW, Deeks SG, Rodriguez B, Valdez H, Shade SB, Abrams DI, et al. Continued CD4 cell count increases in HIV-infected adults experiencing 4 years of viral suppression on antiretroviral therapy. AIDS. 2003;17(13):1907–15.

    Article  PubMed  Google Scholar 

  26. Paterson DL, Swindells S, Mohr J, Brester M, Vergis EN, Squier C, et al. Adherence to protease inhibitor therapy and outcomes in patients with HIV infection. Ann Intern Med. 2000;133(1):21–30.

    Article  CAS  PubMed  Google Scholar 

  27. Cohen MS, Chen YQ, McCauley M, Gamble T, Hosseinipour MC, Kumarasamy N, et al. Prevention of HIV-1 infection with early antiretroviral therapy. N Engl J Med. 2011;365(6):493–505.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  28. Loutfy MR, Wu W, Letchumanan M, Bondy L, Antoniou T, Margolese S, et al. Systematic review of HIV transmission between heterosexual serodiscordant couples where the HIV-positive partner is fully suppressed on antiretroviral therapy. PLoS One. 2013;8(2):e55747.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  29. Golin CE, Liu H, Hays RD, Miller LG, Beck CK, Ickovics J, et al. A prospective study of predictors of adherence to combination antiretroviral medication. J Gen Intern Med. 2002;17(10):756–65.

    Article  PubMed  PubMed Central  Google Scholar 

  30. Vranceanu AM, Safren SA, Lu M, Coady WM, Skolnik PR, Rogers WH, et al. The relationship of post-traumatic stress disorder and depression to antiretroviral medication adherence in persons with HIV. AIDS Patient Care STDS. 2008;22(4):313–21.

    Article  PubMed  Google Scholar 

  31. Wolitski RJ, Fenton KA. Sexual health, HIV, and sexually transmitted infections among gay, bisexual, and other men who have sex with men in the United States. AIDS Behav. 2011;15 Suppl 1:S9–17.

    Article  PubMed  Google Scholar 

  32. Hague JC, Muvva R, Miazad RM. STD coinfection and reinfection following HIV diagnosis: evidence of continued sexual risk behavior. Sex Transm Dis. 2011;38(4):347–8.

    PubMed  Google Scholar 

  33. Whiteside YO, Merchant AT, Hussey J, Adams SA, Duffus WA. Occurrence of new sexually transmitted diseases in males after HIV diagnosis. AIDS Behav. 2013;17(3):1176–84.

    Article  PubMed  Google Scholar 

  34. Pingen M, Nouwen JL, Dinant S, Albert J, Mild M, Brodin J, et al. Therapy failure resulting from superinfection by a drug-resistant HIV variant. Antivir Ther. 2012;17(8):1621–5.

    Article  PubMed  Google Scholar 

  35. Wilson PA, Stadler G, Boone MR, Bolger N. Fluctuations in depression and well-being are associated with sexual risk episodes among HIV-positive men. Health Psychol. 2014;33(7):681–5.

    Article  PubMed  PubMed Central  Google Scholar 

  36. O’Cleirigh CM, Traeger L, Mayer KH, Magidson JF, Safren SA. Anxiety specific pathways to HIV sexual transmission risk behavior among young gay and bisexual men. J Gay Lesbian Ment Health. 2013;17(3):314–26.

    Article  PubMed  PubMed Central  Google Scholar 

  37. Alvy LM, McKirnan DJ, Mansergh G, Koblin B, Colfax GN, Flores SA, et al. Depression is associated with sexual risk among men who have sex with men, but is mediated by cognitive escape and self-efficacy. AIDS Behav. 2011;15(6):1171–9.

    Article  PubMed  Google Scholar 

  38. Brown LK, Lourie KJ, Zlotnick C, Cohn J. Impact of sexual abuse on the HIV-risk-related behavior of adolescents in intensive psychiatric treatment. Am J Psychiatry. 2000;157(9):1413–5.

    Article  CAS  PubMed  Google Scholar 

  39. Crepaz N, Lyles CM, Wolitski RJ, Passin WF, Rama SM, Herbst JH, et al. Do prevention interventions reduce HIV risk behaviours among people living with HIV? A meta-analytic review of controlled trials. AIDS. 2006;20(2):143–57.

    Article  PubMed  Google Scholar 

  40. Johnson WD, Diaz RM, Flanders WD, Goodman M, Hill AN, Holtgrave D, et al. Behavioral interventions to reduce risk for sexual transmission of HIV among men who have sex with men. Cochrane Database Syst Rev. 2008;3, CD001230.

    Google Scholar 

  41. Simoni JM, Pearson CR, Pantalone DW, Marks G, Crepaz N. Efficacy of interventions in improving highly active antiretroviral therapy adherence and HIV-1 RNA viral load. A meta-analytic review of randomized controlled trials. J Acquir Immune Defic Syndr. 2006;43 Suppl 1:S23–35.

    Article  PubMed  PubMed Central  Google Scholar 

  42. Amico KR, Harman JJ, Johnson BT. Efficacy of antiretroviral therapy adherence interventions: a research synthesis of trials, 1996 to 2004. J Acquir Immune Defic Syndr. 2006;41(3):285–97.

    Article  PubMed  Google Scholar 

  43. Simoni JM, Amico KR, Pearson CR, Malow R. Strategies for promoting adherence to antiretroviral therapy: a review of the literature. Curr Infect Dis Rep. 2008;10(6):515–21.

    Article  PubMed  PubMed Central  Google Scholar 

  44. Safren SA, O’Cleirigh CM, Skeer M, Elsesser SA, Mayer KH. Project enhance: a randomized controlled trial of an individualized HIV prevention intervention for HIV-infected men who have sex with men conducted in a primary care setting. Health Psychol. 2013;32(2):171–9.

    Article  PubMed  Google Scholar 

  45. Sikkema KJ, Hansen NB, Kochman A, Tarakeshwar N, Neufeld S, Meade CS, et al. Outcomes from a group intervention for coping with HIV/AIDS and childhood sexual abuse: reductions in traumatic stress. AIDS Behav. 2007;11(1):49–60.

    Article  PubMed  Google Scholar 

  46. Sikkema KJ, Wilson PA, Hansen NB, Kochman A, Neufeld S, Ghebremichael MS, et al. Effects of a coping intervention on transmission risk behavior among people living with HIV/AIDS and a history of childhood sexual abuse. J Acquir Immune Defic Syndr. 2008;47(4):506–13.

    Article  PubMed  Google Scholar 

  47. Wyatt GE, Longshore D, Chin D, Carmona JV, Loeb TB, Myers HF, et al. The efficacy of an integrated risk reduction intervention for HIV-positive women with child sexual abuse histories. AIDS Behav. 2004;8(4):453–62.

    Article  PubMed  Google Scholar 

  48. Safren SA, Gonzalez J, Soroudi N. Coping with chronic illness: a cognitive-behavioral approach for adherence and depression—therapist guide. New York: Oxford University Press; 2007.

    Book  Google Scholar 

  49. Nezu AM, Nezu C, Friedman S, Faddis S, Houts P. Helping cancer patients cope: a problem-solving approach. Washington, DC: American Psychological Association; 1998.

    Book  Google Scholar 

  50. Nezu AM, Nezu C, Friedman S, Houts P, Faddis S. Project genesis: application of problem-solving therapy to individuals with cancer. Behav Ther. 1997;20:55–158.

    Google Scholar 

  51. Thomason BT, Bachanas PJ, Campos PE. Cognitive behavioral interventions with persons affected by HIV/AIDS. Cogn Behav Pract. 1996;3(2):417–42.

    Article  Google Scholar 

  52. Safren SA, Otto MW, Worth JL. Life-steps: applying cognitive behavioral therapy to HIV medication adherence. Cogn Behav Pract. 1999;6(4):332–41.

    Article  Google Scholar 

  53. Beck AT. Cognitive models of depression. J Cogn Psychother. 1987;1(1):5–37.

    Google Scholar 

  54. Safren SA, Gonzalez J, Soroudi N. CBT for depression and adherence in individuals with chronic illness: therapist guide. New York: Oxford University Press; 2008.

    Google Scholar 

  55. Miller WR, Rollnick S. Motivational interviewing: preparing people to change addictive behaviour. New York: Guilford Press; 1991.

    Google Scholar 

  56. Safren SA, O’Cleirigh CM, Tan JY, Raminani SR, Reilly LC, Otto MW, et al. A randomized controlled trial of cognitive behavioral therapy for adherence and depression (CBT-AD) in HIV-infected individuals. Health Psychol. 2009;28(1):1–10.

    Article  PubMed  PubMed Central  Google Scholar 

  57. Newcomb ME, Bedoya CA, Blashill AJ, Lerner JA, O’Cleirigh CM, Pinkston MM, et al. Description and demonstration of cognitive behavioral therapy to enhance antiretroviral therapy adherence and treat depression in HIV-Infected adults. Cogn Behav Pract. 2015;22(4):430–8.

    Article  PubMed  PubMed Central  Google Scholar 

  58. Magidson JF, Seitz-Brown CJ, Safren SA, Daughters SB. Implementing behavioral activation and life-steps for depression and HIV medication adherence in a community health center. Cogn Behav Pract. 2014;21(4):386–403.

    Article  PubMed  PubMed Central  Google Scholar 

  59. McHugh RK, Barlow DH. The dissemination and implementation of evidence-based psychological treatments. A review of current efforts. Am Psychol. 2010;65(2):73–84.

    Article  PubMed  Google Scholar 

  60. Wingood GM, DiClemente RJ. The ADAPT-ITT model: a novel method of adapting evidence-based HIV Interventions. J Acquir Immune Defic Syndr. 2008;47 Suppl 1:S40–6.

    Article  PubMed  Google Scholar 

  61. Saberi P, Yuan P, John M, Sheon N, Johnson MO. A pilot study to engage and counsel HIV-positive African American youth via telehealth technology. AIDS Patient Care STDS. 2013;27(9):529–32.

    Article  PubMed  PubMed Central  Google Scholar 

  62. Wood JA, Miller TW, Hargrove DS. Clinical supervision in rural settings: a telehealth model. Prof Psychol Res Pract. 2005;36(2):173–9.

    Article  Google Scholar 

  63. Khatri N, Marziali E, Tchernikov I, Shepherd N. Comparing telehealth-based and clinic-based group cognitive behavioral therapy for adults with depression and anxiety: a pilot study. Clin Interv Aging. 2014;9:765–70.

    Article  PubMed  PubMed Central  Google Scholar 

  64. Tufts KA, Johnson KF, Shepherd JG, Lee J-Y, Bait Ajzoon MS, Mahan LB, et al. Novel interventions for HIV self-management in African American women: a systematic review of mHealth interventions. J Assoc Nurses AIDS Care. 2015;26(2):139–50.

    Article  PubMed  Google Scholar 

  65. Krakower DS, Jain S, Mayer KH. Antiretrovirals for primary HIV prevention: the current status of pre- and post-exposure prophylaxis. Curr HIV/AIDS Rep. 2015;12(1):127–38.

    Article  PubMed  PubMed Central  Google Scholar 

  66. Grant RM, Lama JR, Anderson PL, McMahan V, Liu AY, Vargas L, et al. Preexposure chemoprophylaxis for HIV prevention in men who have sex with men. N Engl J Med. 2010;363(27):2587–99.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  67. Roland ME, Neilands TB, Krone MR, Katz MH, Franses K, Grant RM, et al. Seroconversion following nonoccupational postexposure prophylaxis against HIV. Clin Infect Dis. 2005;41(10):1507–13.

    Article  PubMed  Google Scholar 

  68. Amico KR, Stirratt MJ. Adherence to preexposure prophylaxis: current, emerging, and anticipated bases of evidence. Clin Infect Dis. 2014;59 Suppl 1:S55–60.

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Aaron Blashill .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2017 Springer Science+Business Media New York

About this chapter

Cite this chapter

Blashill, A., Dale, S., Jampel, J., Safren, S. (2017). HIV. In: Vranceanu, AM., Greer, J., Safren, S. (eds) The Massachusetts General Hospital Handbook of Behavioral Medicine. Current Clinical Psychiatry. Humana Press, Cham. https://doi.org/10.1007/978-3-319-29294-6_11

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-29294-6_11

  • Published:

  • Publisher Name: Humana Press, Cham

  • Print ISBN: 978-3-319-29292-2

  • Online ISBN: 978-3-319-29294-6

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics