Skip to main content
SpringerLink
Log in

18F-FDG PET/CT Imaging: Normal Variants, Pitfalls and Artefacts

  • Chapter
  • First Online:
Book cover PET/CT in Gynecological Cancers

Part of the book series: Clinicians’ Guides to Radionuclide Hybrid Imaging ((PET/CT))

  • 869 Accesses

Abstract

In recent years, positron emission tomography (PET)/computed tomography (CT) has gained widespread clinical acceptance in oncology. It is being used extensively in the diagnosis, staging, restaging and therapy response evaluation of tumours along with several benign indications in cardiology and neurology. Fluorine-18 (18F) 2-fluoro-2-deoxy-D-glucose (FDG) is the most commonly used positron-emitting radiotracer in PET/CT studies. In this chapter, we will mainly focus on normal variants and artefacts in 18F-FDG PET/CT studies.

The original version of this chapter was revised: The erratum to this chapter is available at DOI 10.1007/978-3-319-29249-6_11

An erratum to this chapter can be found at http://dx.doi.org/10.1007/978-3-319-29249-6_11

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Agrawal K, Mittal BR, Bansal D, et al. Role of F-18 FDG PET/CT in assessing bone marrow involvement in pediatric Hodgkin’s lymphoma. Ann Nucl Med. 2013;27(2):146–51.

    Article  CAS  PubMed  Google Scholar 

  2. Mittal BR, Agrawal K. FDG-PET in tuberculosis. Curr Mol Imaging. 2014;3(3):211–5.

    Article  Google Scholar 

  3. Cook GJ, Fogelman I, Maisey MN. Normal physiological and benign pathological variants of 18F-FDG PET scanning: potential for error in interpretation. Semin Nucl Med. 1996;26:308–14.

    Article  CAS  PubMed  Google Scholar 

  4. Cook GJ, Maisey MN, Fogelman I. Normal variants, artefacts and interpretative pitfalls in PET imaging with 18F-fluoro-2-deoxyglucose and carbon-11 methionine. Eur J Nucl Med. 1999;26:1363–78.

    Article  CAS  PubMed  Google Scholar 

  5. Cook GJ, Wegner EA, Fogelman I. Pitfalls and artifacts in 18 FDG PET and PET/CT oncologic imaging. Semin Nucl Med. 2004;34:122–33.

    Article  PubMed  Google Scholar 

  6. Culverwell AD, Scarsbrook AF, Chowdhury FU. False-positive uptake on 2-[18F]-fluoro-2-deoxy-D-glucose (FDG) positron-emission tomography/computed tomography (PET/CT) in oncological imaging. Clin Radiol. 2011;66:366–82.

    Article  CAS  PubMed  Google Scholar 

  7. Shreve PD, Anzai Y, Wahl RL. Pitfalls in oncologic diagnosis with FDG PET imaging: physiologic and benign variants. Radiographics. 1999;19:61–77.

    Article  CAS  PubMed  Google Scholar 

  8. Delbeke D, Coleman RE, Guiberteau MJ, et al. Procedure guideline for tumour imaging with 18F-FDG PET/CT 1.0. J Nucl Med. 2006;47:885–95.

    PubMed  Google Scholar 

  9. Boellaard R, O’Doherty MJ, Weber WA, et al. FDG PET and PET/CT: EANM procedure guidelines for tumour PET imaging: version 1.0. Eur J Nucl Med Mol Imaging. 2010;37:181–200.

    Article  PubMed  Google Scholar 

  10. Segall G, Delbeke D, Stabin MG, et al. SNM practice guideline for sodium 18F-fluoride PET/CT bone scans 1.0. J Nucl Med. 2010;51:1813–20.

    Article  PubMed  Google Scholar 

  11. Juweid ME, Cheson BD. Positron-emission tomography and assessment of cancer therapy. N Engl J Med. 2006;354:496–507.

    Article  CAS  PubMed  Google Scholar 

  12. Gorospe L, Raman S, Echeveste J, et al. Whole-body PET/CT: spectrum of physiological variants, artifacts and interpretative pitfalls in cancer patients. Nucl Med Commun. 2005;26:671–87.

    Article  PubMed  Google Scholar 

  13. Shammas A, Lim R, Charron M. Pediatric FDG PET/CT: physiologic uptake, normal variants, and benign conditions. Radiographics. 2009;29:1467–86.

    Article  PubMed  Google Scholar 

  14. Harisankar CN, Mittal BR, Agrawal KL, et al. Utility of high fat and low carbohydrate diet in suppressing myocardial FDG uptake. J Nucl Cardiol. 2011;18:926–36.

    Article  PubMed  Google Scholar 

  15. Agrawal K, Weaver J, Ngu R, et al. Clinical significance of patterns of incidental thyroid uptake at (18)F-FDG PET/CT. Clin Radiol. 2015;70(5):536–43.

    Article  CAS  PubMed  Google Scholar 

  16. Corrigan AJ, Schleyer PJ, Cook GJ. Pitfalls and artifacts in the use of PET/CT in oncology imaging. Semin Nucl Med. 2015;45(6):481–99.

    Article  PubMed  Google Scholar 

Download references

Acknowledgements

The authors would like to thanks to Dr Nerriman, Dr Riyamma and Dr Halsey for contributing images for the chapter on PET/CT Imaging: Normal Variants, Pitfalls and Artefacts.

Author information

Authors and Affiliations

  1. Department of Nuclear Medicine and PET/CT, North City Hospital, Kolkata, India

    Kanhaiyalal Agrawal

  2. Department of Nuclear Medicine, Royal Free London NHS Foundation Trust, London, UK

    Gopinath Gnanasegaran

  3. Department of Nuclear Medicine, Institute of Nuclear Medicine, UCLH, London, UK

    Evangelia Skoura

  4. Department of Nuclear Medicine and Radiology, Maidstone and Tunbridge Wells NHS Trust, Tunbridge Wells, UK

    Alexis Corrigan

  5. Division of Imaging Sciences and Biomedical Engineering, Nuclear Medicine and Radiology, Clinical PET Centre, St Thomas’ Hospital, Kings College London, London, UK

    Teresa A. Szyszko

Authors
  1. Kanhaiyalal Agrawal
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Gopinath Gnanasegaran
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Evangelia Skoura
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Alexis Corrigan
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Teresa A. Szyszko
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Kanhaiyalal Agrawal .

Editor information

Editors and Affiliations

  1. Imperial College Healthcare NHS Trust, London, United Kingdom

    Tara Barwick

  2. Department of Surgery and Cancer, Imperial College, London, United Kingdom

    Andrea Rockall

Rights and permissions

Reprints and permissions

Copyright information

© 2016 Springer International Publishing Switzerland

About this chapter

Cite this chapter

Agrawal, K., Gnanasegaran, G., Skoura, E., Corrigan, A., Szyszko, T.A. (2016). 18F-FDG PET/CT Imaging: Normal Variants, Pitfalls and Artefacts. In: Barwick, T., Rockall, A. (eds) PET/CT in Gynecological Cancers. Clinicians’ Guides to Radionuclide Hybrid Imaging(). Springer, Cham. https://doi.org/10.1007/978-3-319-29249-6_8

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-29249-6_8

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-29247-2

  • Online ISBN: 978-3-319-29249-6

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation