Abstract
Small bowel transplantation and short bowel syndrome are fields where many ethical issues come to light and leave clinicians with some moral distress. The ethical issues present themselves for most patients in the acute setting of a gastrointestinal catastrophe such as necrotizing enterocolitis totalis or mid-gut volvulus when urgent decisions with possible life-long implications need to be reached quickly. To better understand these ethical issues one has to understand the history of small bowel transplantation, the indications for the procedure, and have a grasp of the recent outcomes. This chapter will succinctly review those medical points before discussing the ethical issues pertaining to pediatric small bowel transplantation. The ethics of emerging technology, best interest principle, accessibility to care, and the societal cost of small bowel transplantation will be explored.
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References
Lillehei RC, Goott B, Miller FA. Homografts of the small bowel. Surg Forum. 1960;10:197–201.
Starzl TE, Kaupp HA Jr. Mass homotransplantations of abdominal organs in dogs. Surg Forum. 1960;11:28–30.
Starzl TE, Rowe MI, Todo S, et al. Transplantation of multiple abdominal viscera. JAMA. 1989;261:1449–57.
Williams JW, Sankary HN, Foster PF, et al. Splanchnic transplantation. An approach to the infant dependent on parenteral nutrition who develops irreversible liver disease. JAMA. 1989;261:1458–62.
Grant D, Wall W, Mimeault R, et al. Successful small bowel/liver transplantation. Lancet. 1990;335:181–4.
Deltz E, Schroeder P, Gedhardt H, et al. Successful clinical small bowel transplantation: report of a case. Clin Transplant. 1989;3:89–91.
Goulet O, Revillon Y, Jan D, et al. Small-bowel transplantation in children. Transplant Proc. 1990;22:2499–500.
Starzl TE, Todo S, Tsakis A, et al. The many faces of multivisceral transplantation. Surg Gynecol Obstet. 1991;172:335–44.
Abu-Elmagd K, Reyes J, Todo S, et al. Clinical intestine al transplantation: new perspectives and immunological considerations. J Am Coll Surg. 1998;186:512–27.
Grant D. Intestinal transplantation: 1997 report of the international registry. Transplantation. 1999;67:1061–4.
Nayyar N, Mazariegos G, Ranganthan S, et al. Pediatric small bowel transplantation. Sem Ped Surg. 2010;19:68–77.
Intestinal transplant registry bi-annual report 2013 available to members at www.tts.org/ita/resources.
Abu-Elmagd KM, Kosmach-Park B, Costa G, et al. Long-term survival, nutritional autonomy, and quality of life after intestinal and multivisceral transplantation. Annals of Surg. 2012;256:494–508.
Nucci AM, Strohm S, Squirer RH, et al. Growth pre- and post-implementation of a steroid-free induction protocol in a large pediatric intestinal transplant population. J Pediatr Gastroentrol Nutr. 2011;52:601–6.
Thevenin DM, Mittal N, Kato T, et al. Neuro-developmental outcomes of infant intestinal transplant recipients. Transpl Proc. 2004;36:319.
Thevenin DM, Baker A, Kato T, et al. Neurodevelopmental outcomes for children transplanted under the age of 3 years. Transpl Proc. 2006;38:1692–3.
Kosmach B. Care routines following pediatric intestine transplantation. In: International symposium on intestinal transplantation. UK: Cambridge; 1997.
Stenn PG, Lammens P, Houle L, et al. Psychiatric psychosocial and ethical aspects of small bowel transplantation. Transpl Proc. 1992;24:1251–2.
Intestine chapter SRTR & OPTN annual data report; 2012. Available on http://optn.transplant.hrsa.gov.
Howard L, Malone M. Current status of home parenteral nutrition in the United States. Transplant Proc. 1996;28:2691–5.
Diamond IR, Sterescu A, Pencharz PB, et al. Changing the paradigm: omegaven for the treatment of liver failure in pediatric short bowel syndrome. J Pediatr Gastroenterol Nutr. 2009;48:209–15.
Oliveira C, De Silva N, Wales PW. Five-year outcomes after serial transverse enteroplasty in children with short bowel syndrome. J Pediatr Surg. 2012;47:931–7.
Kaufman SS, Atkinson JB, Bianchi A, et al. Indications for pediatric intestinal: a position paper of the American society of transplantation. Ped Transplant. 2001;5:80–7.
Goulet O, Ruemmele F. Causes and management of intestinal failure in children. Gastoentero. 2006;130:S16–28.
Cummings CL, Mercurio MR. Ethics of emerging technologies and their transition to acceptable practice: intestinal transplant for short bowel syndrome. J Perinatol. 2012;32:752–6.
Mercer DF, Hobson BD, Gerhardt BK, et al. Serial transverse enteroplasty allows children with short bowel to wean from parenteral nutrition. J Pediatr. 2014;164:93–8.
Wales PW, Jancelewicz T, Romao RL, et al. Delayed primary serial transverse enteroplasty as a novel management strategy for infants with congenital ultra-short bowel syndrome. J Pediatr Surg. 2013;48(5):993–9.
Gambarara M, Ferretti F, Bagolan P, et al. Ultra-short-bowel syndrome is not an absolute indication to small-bowel transplantation in childhood. Eur J of Pediatr Surg. 1999;9:267–70.
Glover JJ, Caniano D, Balint J. Ethical challenges in the care of infants with intestinal failure and lifelong total parenteral nutrition. Seminars in Ped Surg. 2001;10:230–6.
Managing disagreements in the management of short bowel and hypoplastic left heart syndrome. Pediatr 1999;104:e48–e55.
Cummings CL, Diefenbach KA, Mercurio MR. Counselling variation among physicians regarding intestinal transplant for short bowel syndrome. J Med Ethics 2013;0:1–6.
Cummings CL, Mercurio MR. Ethics of emerging technologies and their transition to acceptable practice: intestinal transplant for short bowel syndrome. J Perinatol. 2012;32:752–6.
American Academy of Pediatrics Committee on Fetus Newborn. Policy statement. Noninitiation or withdrawal of intensive care for high-risk newborns. Pediatrics. 2007;119(2):401–3.
Glover JJ, Caniano D, Balint J. Ethical challenges in the care of infants with intestinal failure and lifelong total parenteral nutrition. Seminars in Ped Surg. 2001;10:230–6.
Committee on Bioethics. American academy of pediatrics. Guidelines on forgoing life sustaining medical treatment. Pediatrics. 1994;93:532–6.
http://www.parl.gc.ca/content/sen/committee/372/soci/rep/repoct02vol6part7-e.htm.
Cummings CL, Mercurio MR. Ethics for the pediatrician: autonomy, beneficence and rights. Pediatr Rev. 2010;31:252–5.
DeLegge M, Alsolaiman MM, Barbour E, et al. Short bowel syndrome: parenteral nutrition versus intestinal transplantation. Where are we today? Dig Dis Sci. 2007;52:876–92.
Fryer J, Pellar S, Ormond D, et al. Mortality in candidates waiting for combined liver-intestine transplants exceeds that for other candidates waiting for liver transplants. Liver Transplant. 2003;9:748–53.
Testa G, Holterman M, Abacarian H, et al. Simultaneous or sequential combined living donor-intestine transplantation in children. Transplantation. 2008;85:713–7.
Gangemi A, Tzvetanov IG, Beatty E, et al. Lessons learned in pediatric small bowel and liver transplantation from living-related donors. Transplantation. 2009;87:1027–30.
Panocchia N, Bossola M, Silvestri P. et al. Ethical evaluation of risks related to living donor transplantation programs. Transpl Proc 2013;45:2601–3.
Pruett TL, Tibell A, Alabdulkareem A, et al. The ethics statement of the Vancouver forum on the live lung, liver, pancreas and intestine donor. Transplantation. 2006;81:1386–7.
Abu-Elmagd K, Reyes J, Fung J, et al. Evolution of clinical intestinal transplantation: improved outcome and cost effectiveness. Transpl Proc. 1999;31:582–4.
Cooper TR, Caplan WD, Garcia-Prats JA, et al. The Interrelationship of ethical issues in the transition of old paradigms to new technologies. J Clin Ethics. 1996;7:243–50.
Kamm F. Morality, Mortality volume 1: Death and whom to save from it. New York: Oxford University Press 1998. 353p. ISBN-13: 9780195119114.
Menzel PT. Strong medicine: the ethical rationing of health care. New York: Oxford University Press, 1990. 256p. ISBN-13: 9780195057102.
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Fecteau, A. (2016). Ethical Issues in Pediatric Small Bowel Transplantation. In: Greenberg, R., Goldberg, A., RodrÃguez-Arias, D. (eds) Ethical Issues in Pediatric Organ Transplantation. International Library of Ethics, Law, and the New Medicine, vol 66. Springer, Cham. https://doi.org/10.1007/978-3-319-29185-7_9
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