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Clinical Applications of Stem Cells in Women’s Reproductive Health

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Advances in Stem Cell Therapy

Part of the book series: Stem Cell Biology and Regenerative Medicine ((STEMCELL))

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Abstract

Women’s reproductive health is a broad field that actively interacts with the ongoing stem cell research. One objective of this chapter is to overview the role of tissue specific adult stem cells in the pathogenesis of key disorders affecting women, especially those with a proliferative course such as leiomyoma and endometriosis. Stem cells isolated from these pathologies are used as disease models to investigate their pathogenesis. Similarly, the etiology of obstetric disorders such as preeclampsia, placental insufficiency and trophoblastic diseases were attributed to defective function of the trophoblast stem cells. Common women-specific cancers have been also characterized based on their cancer stem cell population, and several clinical trials are underway to target these cells using novel approaches such as the immune and anti-angiogenic therapies. The second objective of this chapter is to discuss some of the recent applications of the stem cell based therapies in treating women’s and maternal health problems.

Other than the debatable source of embryonic stem cells, the byproducts of delivery such as the umbilical cord blood serve as well-established sources of multipotent stem cells used in several applications, some of which have entered the stage of clinical practice. The use of intrauterine stem cell therapy in fetal medicine is a key approach that can solve hundreds of incurable and serious genetic disorders. Nevertheless, few clinical case reports were published, indicating the urgent need for well-designed clinical trials in this field. The use of autologous germline stem cells in the treatment of infertility, especially when caused by ovarian failure, is a new area of research that is of high promise. It necessitates more robust evidence before considering its application in humans due to its long-term implications for the patient and her offspring.

The original version of this chapter was revised: DOI 10.1007/978-3-319-29149-9_14

An erratum to this chapter can be found at http://dx.doi.org/10.1007/978-3-319-29149-9_14

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Authors and Affiliations

  1. Department of Biomedical Sciences, Center of Excellence for Stem Cells and Regenerative Medicine, Zewail City of Science and Technology, October 6th City, Giza, 12588, Egypt

    Noha Mousa M.D., Ph.D.

  2. Department of Obstetrics and Gynecology, Mayo Clinic, Rochester, MN, USA

    Sherif Abdelkarim Shazly

  3. Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, TX, USA

    Ahmed Abobakr Nassr

  4. Department of Obstetrics and Gynecology, Women’s Health Hospital, Assiut University, Assiut, Egypt

    Ahmed Abobakr Nassr

Authors
  1. Noha Mousa M.D., Ph.D.
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  2. Sherif Abdelkarim Shazly
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  3. Ahmed Abobakr Nassr
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Corresponding author

Correspondence to Noha Mousa M.D., Ph.D. .

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Editors and Affiliations

  1. Center of Excellence for Stem Cells and Regenerative Medicine, Zewail City of Science and Technology, Zayed City, Egypt

    Nagwa El-Badri

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Mousa, N., Shazly, S.A., Nassr, A.A. (2017). Clinical Applications of Stem Cells in Women’s Reproductive Health. In: El-Badri, N. (eds) Advances in Stem Cell Therapy. Stem Cell Biology and Regenerative Medicine. Humana Press, Cham. https://doi.org/10.1007/978-3-319-29149-9_6

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