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Dental Stem Cells in Oral, Maxillofacial and Craniofacial Regeneration

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Dental Stem Cells

Part of the book series: Stem Cell Biology and Regenerative Medicine ((STEMCELL))

Abstract

Regeneration in oral and craniofacial regions includes several specified tissues such as pulp, bone, cartilage, muscle, fat, blood vessels and neurons. Neural crest-derived dental stem cells (DSCs) as a medical waste hold a promise for regeneration in craniofacial region. Five different DSCs have been isolated and characterized: Dental pulp stem cells (DPSCs), stem cells from apical papillae (SCAPs), stem cells obtained from human exfoliated deciduous teeth (SHEDs), dental follicle stem cells (DFSCs) and periodontal ligament stem cells (PDLSCs). These dental tissue- derived stem cells have demonstrated the capability to differentiate towards various cell lineages including adipogenic, chondrogenic, osteogenic, and neurogenic in vitro. Moreover, various studies have shown their potential for regeneration of dentin/pulp, bone, neural, vascular, muscle, cartilage and adipose tissues. Application of DSCs for oral and craniofacial tissues is still in its infancy. However, this chapter will provide insight towards the progress being made regarding utilization of DSCs in oral, maxillofacial and craniofacial regeneration.

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Authors and Affiliations

  1. School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Arash Khojasteh DMD, MS, PhD Candidate

  2. Faculty of Medicine, University of Antwerp, Antwerp, Belgium

    Arash Khojasteh DMD, MS, PhD Candidate

  3. Research Institute of Dental Sciences, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Pantea Nazeman DDS & Maryam Rezai Rad DDS, PhD

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  1. Arash Khojasteh DMD, MS, PhD Candidate
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  2. Pantea Nazeman DDS
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  3. Maryam Rezai Rad DDS, PhD
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Correspondence to Arash Khojasteh DMD, MS, PhD Candidate .

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  1. Yeditepe University, Genetics and Bioengineering Department, Istanbul, Turkey

    Fikrettin Şahin

  2. Yeditepe University, Genetics and Bioengineering Department, Istanbul, Turkey

    Ayşegül Doğan

  3. Yeditepe University, Genetics and Bioengineering Department, ISTANBUL, Turkey

    Selami Demirci

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Khojasteh, A., Nazeman, P., Rad, M.R. (2016). Dental Stem Cells in Oral, Maxillofacial and Craniofacial Regeneration. In: Şahin, F., Doğan, A., Demirci, S. (eds) Dental Stem Cells. Stem Cell Biology and Regenerative Medicine. Springer, Cham. https://doi.org/10.1007/978-3-319-28947-2_8

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