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Immunomodulatory Properties of Stem Cells Derived from Dental Tissues

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Dental Stem Cells

Part of the book series: Stem Cell Biology and Regenerative Medicine ((STEMCELL))

Abstract

In the last decade, researchers have given great attention to understand the immunomodulatory mechanisms mediated by mesenchymal stem cells (MSCs). In addition to their high proliferative and differentiation features, MSCs can also display strong immunomodulatory roles both in vitro and in vivo, which make them a unique immunotherapeutic agent for the treatment of various autoimmune and inflammation associated diseases. Tissue engineering approaches using dental tissue derived MSCs (DSCs) are recently anticipated in future regenerative therapies. While DSCs use in transplantation studies significantly reduces host immune response against the donor cells, obtainability of DSCs can vary among the individuals. This immunomodulatory role is mainly mediated by T lymphocytes, B lymphocytes, dendritic cells and natural killer cells via interleukin (IL)-2 utilization. In addition, DSCs have promising potential to be used in the treatment of organ transplant refusal and autoimmune inflammatory bowel disorders where immunomodulation and tissue repair activities are both required. In this regard, remarkable immune suppressor properties make DSCs valuable stem cells sources to be used in cell-based therapy approaches in the near future.

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Authors and Affiliations

  1. Department of Genetics and Bioengineering, Faculty of Engineering and Architecture, Yeditepe University, 26 Ağustos Campus, Kayisdagi cad. Kayisdagi, TR-34755, Istanbul, Turkey

    Pakize Neslihan Taşlı & Safa Aydın

  2. Genetics and Bioengineering Department, Yeditepe University, Istanbul, Turkey

    Fikrettin Şahin

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  1. Pakize Neslihan Taşlı
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  2. Safa Aydın
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  3. Fikrettin Şahin
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  1. Yeditepe University, Genetics and Bioengineering Department, Istanbul, Turkey

    Fikrettin Şahin

  2. Yeditepe University, Genetics and Bioengineering Department, Istanbul, Turkey

    Ayşegül Doğan

  3. Yeditepe University, Genetics and Bioengineering Department, ISTANBUL, Turkey

    Selami Demirci

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Taşlı, P.N., Aydın, S., Şahin, F. (2016). Immunomodulatory Properties of Stem Cells Derived from Dental Tissues. In: Şahin, F., Doğan, A., Demirci, S. (eds) Dental Stem Cells. Stem Cell Biology and Regenerative Medicine. Springer, Cham. https://doi.org/10.1007/978-3-319-28947-2_2

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