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Biosensors for Security and Bioterrorism Applications pp 35–59Cite as

New Routes in the High-Throughput Screening of Toxic Proteins Using Immunochemical Tools

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Abstract

The chapter reviews several aspects related to the mechanism of action of toxic proteins used as biological warfare agents, together with the latest advances in immunosensor development. Emphasis will be put on the role played by the nanoparticle technology in the sensing and transduction design. The potential applications of the nanostructured immunosensors in point-of-care systems and the amenability of these devices for detection on-the-field will be critically commented.

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Acknowledgement

The authors would like to acknowledge the financial support of: Romanian National Authority for Scientific Research grant project PN-II-ID-PCE-2011-3-0286 and the networking contribution by the COST Action CM1407 “Challenging organic syntheses inspired by nature—from natural products chemistry to drug discovery”.

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Authors and Affiliations

  1. R&D Center LaborQ, University of Bucharest, 4-12 Regina Elisabeta Blvd., 030018, Bucharest, Romania

    Mihaela Puiu & Camelia Bala

  2. Department of Analytical Chemistry, University of Bucharest, 4-12 Regina Elisabeta Blvd., 030018, Bucharest, Romania

    Camelia Bala

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  1. Mihaela Puiu
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Correspondence to Camelia Bala .

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  1. University of Athens, Athens, Greece

    Dimitrios P. Nikolelis

  2. Lab. of Inorganic & Analytic Chemistry, National Technical University of Athens, Athens, Greece

    Georgia-Paraskevi Nikoleli

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Puiu, M., Bala, C. (2016). New Routes in the High-Throughput Screening of Toxic Proteins Using Immunochemical Tools. In: Nikolelis, D., Nikoleli, GP. (eds) Biosensors for Security and Bioterrorism Applications. Advanced Sciences and Technologies for Security Applications. Springer, Cham. https://doi.org/10.1007/978-3-319-28926-7_3

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