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Biosensors for Detection of Anticholinesterase Agents

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Biosensors for Security and Bioterrorism Applications

Abstract

Cholinesterase biosensors based on various transducers and enzyme carriers have been considered in terms of inhibitor determination. The mechanism of inhibition and influence of immobilization on biosensor performance are briefly considered. The assembly of biosensors for inhibitor detection and measurement conditions are summarized for the period from 2011 to 2015 with particular emphasis to the influence of the sample matrix and immobilization protocol on the sensitivity of inhibitors detection. Finally, the prospects of cholinesterase biosensors are considered, especially those related to miniaturization and operation in extreme environment.

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Acknowledgments

This work has funded by the subsidy allocated to Kazan Federal University for the project part of the state assignment in the sphere of scientific activities.

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  1. A.M. Butlerov’ Chemistry Institute of Kazan Federal University, 18, Kremlevskaya Street, Kazan, 420008, Russian Federation

    Gennady Evtugyn

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  1. Gennady Evtugyn
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  1. University of Athens, Athens, Greece

    Dimitrios P. Nikolelis

  2. Lab. of Inorganic & Analytic Chemistry, National Technical University of Athens, Athens, Greece

    Georgia-Paraskevi Nikoleli

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Evtugyn, G. (2016). Biosensors for Detection of Anticholinesterase Agents. In: Nikolelis, D., Nikoleli, GP. (eds) Biosensors for Security and Bioterrorism Applications. Advanced Sciences and Technologies for Security Applications. Springer, Cham. https://doi.org/10.1007/978-3-319-28926-7_17

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