Abstract
The degree of homogeneity and the mechanical properties of topical polymeric films for drug delivery are vital to their efficacy.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
M.E. Lauer, O. Grassmann, M. Siam, J. Tardio, L. Jacob, S. Page, J.H. Kindt, A. Engel, J. Alsenz, Atomic force microscopy-based screening of drug-excipient miscibility and stability of solid dispersions. Pharm. Res. 28(3), 572–584 (2011)
Y.T.A. Tumer, C.J. Roberts, M.C. Davies, Scanning probe microscopy in the field of drug delivery. Adv. Drug Delivery Rev. 59(14), 1453–1473 (2007)
M.E. Aulton, M.H. Abdulrazzak, J.E. Hogan, The mechanical-properties of hydroxypropylmethylcellulose films derived from aqueous systems. 1. The influence of plasticizers. Drug Dev. Ind. Pharm. 7(6), 649–668 (1981)
J.W. McGinity, L.A. Felton, Aqueous polymeric coatings for pharmaceutical dosage forms, 3rd edn., Drugs and the pharmaceutical sciences (Informa Healthcare, New York, 2008)
M.E. Lauer, M. Siam, J. Tardio, S. Page, J.H. Kindt, O. Grassmann, Rapid assessment of homogeneity and stability of amorphous solid dispersions by atomic force microscopy-from bench to batch. Pharm. Res. 30(8), 2010–2022 (2013)
A. Danesh, X. Chen, M.C. Davies, C.J. Roberts, G.H.W. Sanders, S.J.B. Tendler, P.M. Williams, M.J. Wilkins, Polymorphic discrimination using atomic force microscopy: Distinguishing between two polymorphs of the drug cimetidine. Langmuir 16(2), 866–870 (2000)
S. Ward, M. Perkins, J.X. Zhang, C.J. Roberts, C.E. Madden, S.Y. Luk, N. Patel, S.J. Ebbens, Identifying and mapping surface amorphous domains. Pharm. Res. 22(7), 1195–1202 (2005)
R. Price, P.M. Young, Visualization of the crystallization of lactose from the amorphous state. J. Pharm. Sci. 93(1), 155–164 (2004)
A.Q.J. Low, J. Parmentier, Y.M. Khong, C.C.E. Chai, T.Y. Tun, J.E. Berania, X.M. Liu, R. Gokhale, S.Y. Chan, Effect of type and ratio of solubilising polymer on characteristics of hot-melt extruded orodispersible films. Int. J. Pharm. 455(1–2), 138–147 (2013)
F. Lecomte, J. Siepmann, M. Walther, R.J. MacRae, R. Bodmeier, Polymer blends used for the aqueous coating of solid dosage forms: importance of the type of plasticizer. J. Controlled Release 99(1), 1–13 (2004)
S.Y. Lin, C.J. Lee, Y.Y. Lin, Drug-polymer interaction affecting the mechanical-properties, adhesion strength and release kinetics of piroxicam-loaded eudragit-e films plasticized with different plasticizers. J. Controlled Release 33(3), 375–381 (1995)
C.B. Wu, J.W. McGinity, Non-traditional plasticization of polymeric films. Int. J. Pharm. 177(1), 15–27 (1999)
J. Siepmann, R.A. Siegel, M.J. Rathbone, Fundamentals and applications of controlled release drug delivery, Advances in delivery science and technology (Controlled Release Society, Springer, New York, 2012)
M.L. Oyen, R.R. Cook, A practical guide for analysis of nanoindentation data. J. Mech. Behav. Biomed. Mater. 2(4), 396–407 (2009)
M.L. Oyen, R.F. Cook, Load-displacement behavior during sharp indentation of viscous-elastic-plastic materials. J. Mater. Res. 18(1), 139–150 (2003)
D.C. Lin, D.I. Shreiber, E.K. Dimitriadis, F. Horkay, Spherical indentation of soft matter beyond the hertzian regime: numerical and experimental validation of hyperelastic models. Biomech. Model. Mechanobiol. 8(5), 345–358 (2009)
J.D. Beard, R.H. Guy, S.N. Gordeev, Mechanical tomography of human corneocytes with a nanoneedle. J. Invest. Dermatol. 133, 1565–1571 (2013)
M.A. Repka, J.W. McGinity, Physical-mechanical, moisture absorption and bioadhesive properties of hydroxypropylcellulose hot-melt extruded films. Biomaterials 21(14), 1509–1517 (2000)
C. Padula, G. Colombo, S. Nicoli, P.L. Catellani, G. Massimo, P. Santi, Bioadhesive film for the transdermal delivery of lidocaine: in vitro and in vivo behavior. J. Controlled Release 88(2), 277–285 (2003)
J.C. Gutierrez-Rocca, J.W. Mcginity, Influence of water-soluble and insoluble plasticizers on the physical and mechanical-properties of acrylic resin copolymers. Int. J. Pharm. 103(3), 293–301 (1994)
K. Frederiksen, R.H. Guy, K. Petersson, Formulation considerations in the design of topical, polymeric film-forming systems for sustained drug delivery to the skin. Eur. J. Pharm. Biopharm. 91, 9–15 (2015)
L.A. Wegiel, L.J. Mauer, K.J. Edgar, L.S. Taylor, Crystallization of amorphous solid dispersions of resveratrol during preparation and storage-impact of different polymers. J. Pharm. Sci. 102(1), 171–184 (2013)
J. Bajdik, G. Regdon, T. Marek, I. Eros, K. Suvegh, K. Pintye-Hodi, The effect of the solvent on the film-forming parameters of hydroxypropyl-cellulose. Int. J. Pharm. 301(1–2), 192–198 (2005)
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
Copyright information
© 2016 Springer International Publishing Switzerland
About this chapter
Cite this chapter
Garvie-Cook, H. (2016). TEC Plasticization of Topical Polymeric Films. In: Novel (Trans)dermal Drug Delivery Strategies. Springer Theses. Springer, Cham. https://doi.org/10.1007/978-3-319-28901-4_4
Download citation
DOI: https://doi.org/10.1007/978-3-319-28901-4_4
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-28900-7
Online ISBN: 978-3-319-28901-4
eBook Packages: Physics and AstronomyPhysics and Astronomy (R0)