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Translational Research and Immunotherapy in Lung Cancer

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Principles and Practice of Radiotherapy Techniques in Thoracic Malignancies

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Abstract

Understanding of the biological underpinnings of the development of metastatic disease and therapeutic resistance has greatly increased over the past few decades. Initially, these insights came slowly because only one protein or gene or signaling pathway could be studied at a time. The process of elucidating how one gene could influence downstream pathways, or even resistance pathways, was slow and tedious but was quickened through translational work that allowed insights from the bench to be translated to the bedside and vice versa. This process has since given way to more comprehensive approaches that allow the study of hundreds of genes or proteins at a time through microarray analysis. Rapid advances in DNA, RNA, and protein sequencing are showing us that we have only begun to uncover small pieces of much larger puzzles, including the importance of cross-disciplinary work with fields like immunology. The importance of cancer immunology in the treatment of thoracic malignancies has rapidly gained recognition, particularly with the explosion of new therapeutic agents that can reactivate immune responses that have been approved by the US Food and Drug Administration (FDA) over a relatively brief period. Future challenges lie in finding ways to integrate genomic information with immunotherapy to further advance precisely personalized medicine in the hopes of eradicating thoracic cancer.

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Authors and Affiliations

  1. Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, B24595, Unit 97, Houston, TX, USA

    Jonathan E. Schoenhals, Maria A. Cortez, Sharareh Niknam, Daniel R. Gomez, Zhongxing Liao MD & James W. Welsh MD

  2. Department of Medicine, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USA

    Eric D. Brooks

  3. Department of Radiation Oncology, University of Iowa Hospitals and Clinics, LL PFPW 200 Hawkins Dr, Iowa City, IA, 52242, USA

    Steven N. Seyedin

  4. Institute for Applied Cancer Science, The University of Texas MD Anderson Cancer Center, 1901 East Road, Houston, TX, USA

    Xiaohong Wang

  5. Yale University, New Haven, CT, 06520, USA

    Alexandra P. Cadena

  6. Biomedical Informatics at Molecular Match Inc., TMC X+ 220 2450 Holcombe Blvd, Houston, TX, 77021, USA

    Xuan Shirley Li

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  1. Jonathan E. Schoenhals
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Correspondence to James W. Welsh MD .

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Editors and Affiliations

  1. Department of Radiation Oncology, Hacettepe University, Faculty of Med., Ankara, Turkey

    Gokhan Ozyigit

  2. Department of Radiation Oncology, Koc University, Faculty of Medicine, Istanbul, Turkey

    Ugur Selek

  3. Department of Radiation Oncology, Baskent University School of Medicine, Adana, Turkey

    Erkan Topkan

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Schoenhals, J.E. et al. (2016). Translational Research and Immunotherapy in Lung Cancer. In: Ozyigit, G., Selek, U., Topkan, E. (eds) Principles and Practice of Radiotherapy Techniques in Thoracic Malignancies. Springer, Cham. https://doi.org/10.1007/978-3-319-28761-4_12

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