Skip to main content

The Use of Electroceuticals and Neuromodulation in the Treatment of Migraine and Other Headaches

  • Chapter
  • First Online:
Electroceuticals

Abstract

Over recent years there has been increasing interest in the role of neurostimulation in the treatment of headache disorders. Currently both peripheral and central neuromodulation devices are available although evidence to support their use is still limited. Both non-invasive and invasive devices can be used for neurostimulation. Non-invasive peripheral stimulation options include supra-orbital stimulation (Cefaly® device) and vagal nerve stimulation (gammaCore® device), while invasive peripheral stimulation options include occipital nerve stimulation and sphenopalatine ganglion stimulation. Non-invasive central neurostimulation option involves single pulse transcranial magnetic stimulation (SpringTMS® device), while invasive central neurostimulation can be carried out using ventral tegmental area deep brain stimulation. Neurostimulation therapies offer a promising approach to otherwise medically intractable or difficult to treat headache disorders with each device having specific roles within the treatment pathway.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 139.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 179.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 179.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Headache Classification Committee of the International Headache Society. The International Classification of Headache Disorders, 3rd edition (beta version). Cephalalgia: Int J Headache. 2013;33(9):629–808.

    Article  Google Scholar 

  2. Stewart WF, Shechter A, Rasmussen BK. Migraine prevalence. A review of population-based studies. Neurology. 1994;44(6 Suppl 4):S17–23.

    CAS  PubMed  Google Scholar 

  3. Bjørn RM. Epidemiology and genetics of cluster headache. Lancet Neurol. 2004;3(5):279–83.

    Article  Google Scholar 

  4. Sjaastad O, Bakketeig LS. Cluster headache prevalence. Vaga study of headache epidemiology. Cephalalgia: Int J Headache. 2003;23(7):528–33.

    Article  CAS  Google Scholar 

  5. World Health Organisation. Atlas of headache disorders and resources in the world 2011. A collaberation project of the World Health Organisation and Lifting the Burden. WHO Press, World Health Organization, 20 Avenue Appia, 1211 Geneva 27, Switzerland; 2011.

    Google Scholar 

  6. Scher AI, Stewart WF, Liberman J, Lipton RB. Prevalence of frequent headache in a population sample. Headache. 1998;38(7):497–506.

    Article  CAS  PubMed  Google Scholar 

  7. Burstein R, Noseda R, Borsook D. Migraine: multiple processes, complex pathophysiology. J Neurosci Off J Soc Neurosci. 2015;35(17):6619–29.

    Article  CAS  Google Scholar 

  8. Kerr FW, Olafson RA. Trigeminal and cervical volleys. Convergence on single units in the spinal gray at C-1 and C-2. Arch Neurol. 1961;5:171–8.

    Article  CAS  PubMed  Google Scholar 

  9. Lipton RB, Pearlman SH. Transcranial magnetic simulation in the treatment of migraine. Neurotherapeutics. 2010;7(2):204–12.

    Article  PubMed  PubMed Central  Google Scholar 

  10. Charles AC, Baca SM. Cortical spreading depression and migraine. Nat Rev Neurol. 2013;9(11):637–44.

    Article  PubMed  Google Scholar 

  11. Goadsby PJ, Edvinsson L. Human in vivo evidence for trigeminovascular activation in cluster headache. Neuropeptide changes and effects of acute attacks therapies. Brain J Neurol. 1994;117(Pt 3):427–34.

    Article  Google Scholar 

  12. Matharu MS, Cohen AS, Frackowiak RS, Goadsby PJ. Posterior hypothalamic activation in paroxysmal hemicrania. Ann Neurol. 2006;59(3):535–45.

    Article  PubMed  Google Scholar 

  13. Matharu MS, Cohen AS, McGonigle DJ, Ward N, Frackowiak RS, Goadsby PJ. Posterior hypothalamic and brainstem activation in hemicrania continua. Headache. 2004;44(8):747–61.

    Article  PubMed  Google Scholar 

  14. May A, Bahra A, Büchel C, et al. Hypothalamic activation in cluster headache attacks. Lancet. 1998;352:275–8.

    Article  CAS  PubMed  Google Scholar 

  15. May A, Bahra A, Buchel C, Turner R, Goadsby PJ. Functional magnetic resonance imaging in spontaneous attacks of SUNCT: short-lasting neuralgiform headache with conjunctival injection and tearing. Ann Neurol. 1999;46(5):791–4.

    Article  CAS  PubMed  Google Scholar 

  16. Bartsch T, Levy MJ, Knight YE, Goadsby PJ. Differential modulation of nociceptive dural input to [hypocretin] orexin A and B receptor activation in the posterior hypothalamic area. Pain. 2004;109(3):367–78.

    Article  CAS  PubMed  Google Scholar 

  17. Gerardy PY, Fabry D, Fumal A, Schoenen J. A pilot study on supra-orbital surface electrotherapy in migraine. Cephalalgia. 2009;29:101–78.

    Article  Google Scholar 

  18. Schoenen J, Vandersmissen B, Jeangette S, Herroelen L, Vandenheede M, Gerard P, et al. Migraine prevention with a supraorbital transcutaneous stimulator: a randomized controlled trial. Neurology. 2013;80(8):697–704.

    Article  PubMed  Google Scholar 

  19. Magis D, Sava S, d'Elia TS, Baschi R, Schoenen J. Safety and patients’ satisfaction of transcutaneous supraorbital neurostimulation (tSNS) with the Cefaly(R) device in headache treatment: a survey of 2,313 headache sufferers in the general population. J Headache Pain. 2013;14:95.

    Article  PubMed  PubMed Central  Google Scholar 

  20. Linde K, Rossnagel K. Propranolol for migraine prophylaxis. Cochrane Database Syst Rev. 2004;(2):CD003225.

    Google Scholar 

  21. Asensio-Samper JM, Villanueva VL, Perez AV, Lopez MD, Monsalve V, Moliner S, et al. Peripheral neurostimulation in supraorbital neuralgia refractory to conventional therapy. Pain Pract: Off J World Institute Pain. 2008;8(2):120–4.

    Article  Google Scholar 

  22. Reed K, Black S, Banta C, Will K. Combined occipital and supraorbital neurostimulation for the treatment of chronic migraine headaches: initial experience. Cephalalgia: Int J Headache. 2010;30(3):260–71.

    Article  CAS  Google Scholar 

  23. Hann S, Sharan A. Dual occipital and supraorbital nerve stimulation for chronic migraine: a single-center experience, review of literature, and surgical considerations. Neurosurg Focus. 2013;35(3):E9.

    Article  PubMed  Google Scholar 

  24. Narouze SN, Kapural L. Supraorbital nerve electric stimulation for the treatment of intractable chronic cluster headache: a case report. Headache. 2007;47(7):1100–2.

    Article  PubMed  Google Scholar 

  25. Vaisman J, Markley H, Ordia J, Deer T. The treatment of medically intractable trigeminal autonomic cephalalgia with supraorbital/supratrochlear stimulation: a retrospective case series. Neuromodulation: J Int Neuromodulation Soc. 2012;15(4):374–80.

    Article  Google Scholar 

  26. Sadler RM, Purdy RA, Rahey S. Vagal nerve stimulation aborts migraine in patient with intractable epilepsy. Cephalalgia: Int J Headache. 2002;22(6):482–4.

    Article  CAS  Google Scholar 

  27. Gaul C, Diener HC, Silver N, Magis D, Reuter U, Andersson A, et al. Non-invasive vagus nerve stimulation for PREVention and Acute treatment of chronic cluster headache (PREVA): a randomised controlled study. Cephalalgia: Int J Headache. 2016;36:534–46.

    Article  Google Scholar 

  28. Nesbitt AD, Marin JC, Tompkins E, Ruttledge MH, Goadsby PJ. Initial use of a novel noninvasive vagus nerve stimulator for cluster headache treatment. Neurology. 2015;84:1249–53.

    Article  CAS  PubMed  Google Scholar 

  29. Silberstein S, Neves Da Silva A, Calhoun A, Grosberg B, Lipton R, Cady R, et al. Non-Invasive Vagus Nerve Stimulation for Chronic Migraine Prevention in a Propective, Randomized, Sham-Controlled Pilot Study (the EVENT Study): Report from the Double-blind Phase. Headache: J Head Face Pain. 2014;54:1–74.

    Article  Google Scholar 

  30. Silberstein S, Neves Da Silva A, Calhoun A, Grosberg B, Lipton RB, Cady R, et al. Chronic Migraine Prevention with non-invasive Vagus Nerve Stimulation in a Prospective Pilot Study (the EVENT Study): Report from the Open-label Phase. Headache: J Head Face Pain. 2014;54:1–74.

    Article  Google Scholar 

  31. Goadsby P, Grosberg B, Mauskop A, Cady R, Simmons K. Effect of noninvasive vagus nerve stimulation on acute migraine: An open-label pilot study. Cephalalgia: Int J Headache. 2014;34(12):986–93.

    Article  CAS  Google Scholar 

  32. Barbanti P, Grazzi L, Egeo G, Padovan AM, Liebler E, Bussone G. Non-invasive vagus nerve stimulation for acute treatment of high-frequency and chronic migraine: an open-label study. J Headache Pain. 2015;16:61.

    Article  PubMed  PubMed Central  Google Scholar 

  33. Bellavance AJ, Meloche JP. A comparative study of naproxen sodium, pizotyline and placebo in migraine prophylaxis. Headache. 1990;30(11):710–5.

    Article  CAS  PubMed  Google Scholar 

  34. Cady RK, Sheftell F, Lipton RB, O'Quinn S, Jones M, Gayla Putnam D, et al. Effect of early intervention with sumatriptan on migraine pain: retrospective analyses of data from three clinical trials. Clin Ther. 2000;22(9):1035–48.

    Article  CAS  PubMed  Google Scholar 

  35. Krishna V, Sammartino F, King NK, So RQ, Wennberg R. Neuromodulation for epilepsy. Neurosurg Clin N Am. 2016;27(1):123–31.

    Article  PubMed  Google Scholar 

  36. Mauskop A. Vagus nerve stimulation relieves chronic refractory migraine and cluster headaches. Cephalalgia: Int J Headache. 2005;25(2):82–6.

    Article  CAS  Google Scholar 

  37. Cecchini AP, Mea E, Tullo V, Curone M, Franzini A, Broggi G, et al. Vagus nerve stimulation in drug-resistant daily chronic migraine with depression: preliminary data. Neurol Sci: Off J Italian Neurol Soc Italian Soc Clin Neurophysiol. 2009;30(Suppl 1):S101–4.

    Article  Google Scholar 

  38. Hord ED, Evans MS, Mueed S, Adamolekun B, Naritoku DK. The effect of vagus nerve stimulation on migraines. J Pain. 2003;4(9):530–4.

    Article  PubMed  Google Scholar 

  39. Poletti CE. C2 and C3 pain dermatomes in man. Cephalalgia: Int J Headache. 1991;11(3):155–9.

    Article  CAS  Google Scholar 

  40. Saper JR, Dodick DW, Silberstein SD, McCarville S, Sun M, Goadsby PJ. Occipital nerve stimulation for the treatment of intractable chronic migraine headache: ONSTIM feasibility study. Cephalalgia: Int J Headache. 2011;31(3):271–85.

    Article  Google Scholar 

  41. Silberstein SD, Dodick DW, Saper J, Huh B, Slavin KV, Sharan A, et al. Safety and efficacy of peripheral nerve stimulation of the occipital nerves for the management of chronic migraine: results from a randomized, multicenter, double-blinded, controlled study. Cephalalgia: Int J Headache. 2012;32(16):1165–79.

    Article  Google Scholar 

  42. Dodick DW, Silberstein SD, Reed KL, Deer TR, Slavin KV, Huh B, et al. Safety and efficacy of peripheral nerve stimulation of the occipital nerves for the management of chronic migraine: long-term results from a randomized, multicenter, double-blinded, controlled study. Cephalalgia: Int J Headache. 2015;35(4):344–58.

    Article  Google Scholar 

  43. Brewer AC, Trentman TL, Ivancic MG, Vargas BB, Rebecca AM, Zimmerman RS, et al. Long-term outcome in occipital nerve stimulation patients with medically intractable primary headache disorders. Neuromodulation: J Int Neuromodulation Soc. 2013;16(6):557–62.

    Article  Google Scholar 

  44. Lipton R, Goadsby PJ, Cady R, Aurora SK, Grosberg BM, Freitag F, et al. PRISM study: occipital nerve stimulation for treatment-refractory migraine. Cephalalgia. 2009;29(Suppl 1):30.

    Google Scholar 

  45. Mueller O, Diener HC, Dammann P, Rabe K, Hagel V, Sure U, et al. Occipital nerve stimulation for intractable chronic cluster headache or migraine: a critical analysis of direct treatment costs and complications. Cephalalgia: Int J Headache. 2013;33(16):1283–91.

    Article  Google Scholar 

  46. Paemeleire K, Van Buyten JP, Van Buynder M, Alicino D, Van Maele G, Smet I, et al. Phenotype of patients responsive to occipital nerve stimulation for refractory head pain. Cephalalgia: Int J Headache. 2010;30(6):662–73.

    CAS  Google Scholar 

  47. Magis D, Allena M, Bolla M, De Pasqua V, Remacle JM, Schoenen J. Occipital nerve stimulation for drug-resistant chronic cluster headache: a prospective pilot study. Lancet Neurol. 2007;6(4):314–21.

    Article  PubMed  Google Scholar 

  48. Magis D, Gerardy PY, Remacle JM, Schoenen J. Sustained effectiveness of occipital nerve stimulation in drug-resistant chronic cluster headache. Headache. 2011;51(8):1191–201.

    Article  PubMed  Google Scholar 

  49. Schwedt TJ, Dodick DW, Hentz J, Trentman TL, Zimmerman RS. Occipital nerve stimulation for chronic headache–long-term safety and efficacy. Cephalalgia: Int J Headache. 2007;27(2):153–7.

    Article  CAS  Google Scholar 

  50. Burns B, Watkins L, Goadsby PJ. Treatment of medically intractable cluster headache by occipital nerve stimulation: long-term follow-up of eight patients. Lancet. 2007;369(9567):1099–106.

    Article  PubMed  Google Scholar 

  51. Burns B, Watkins L, Goadsby PJ. Treatment of intractable chronic cluster headache by occipital nerve stimulation in 14 patients. Neurology. 2009;72(4):341–5.

    Article  CAS  PubMed  Google Scholar 

  52. Fontaine D, Christophe Sol J, Raoul S, Fabre N, Geraud G, Magne C, et al. Treatment of refractory chronic cluster headache by chronic occipital nerve stimulation. Cephalalgia: Int J Headache. 2011;31(10):1101–5.

    Article  Google Scholar 

  53. Mueller OM, Gaul C, Katsarava Z, Diener HC, Sure U, Gasser T. Occipital nerve stimulation for the treatment of chronic cluster headache – lessons learned from 18 months experience. Cen Eur Neurosurg. 2011;72(2):84–9.

    Article  CAS  Google Scholar 

  54. Lambru G, Shanahan P, Watkins L, Matharu MS. Occipital nerve stimulation in the treatment of medically intractable SUNCT and SUNA. Pain Physician. 2014;17(1):29–41.

    PubMed  Google Scholar 

  55. Burns B, Watkins L, Goadsby PJ. Treatment of hemicrania continua by occipital nerve stimulation with a bion device: long-term follow-up of a crossover study. Lancet Neurol. 2008;7(11):1001–12.

    Article  PubMed  Google Scholar 

  56. Silberstein S, Tfelt-Hansen P, Dodick DW, Limmroth V, Lipton RB, Pascual J, et al. Guidelines for controlled trials of prophylactic treatment of chronic migraine in adults. Cephalalgia: Int J Headache. 2008;28(5):484–95.

    Article  CAS  Google Scholar 

  57. Chen YF, Bramley G, Unwin G, Hanu-Cernat D, Dretzke J, Moore D, et al. Occipital nerve stimulation for chronic migraine–a systematic review and meta-analysis. PLoS One. 2015;10(3):e0116786.

    Article  PubMed  PubMed Central  Google Scholar 

  58. Weiner RL, Reed KL. Peripheral neurostimulation for control of intractable occipital neuralgia. Neuromodulation: J Int Neuromodulation Soc. 1999;2(3):217–21.

    Article  CAS  Google Scholar 

  59. Popeney CA, Alo KM. Peripheral neurostimulation for the treatment of chronic, disabling transformed migraine. Headache. 2003;43(4):369–75.

    Article  PubMed  Google Scholar 

  60. Johnstone CS, Sundaraj R. Occipital nerve stimulation for the treatment of occipital neuralgia-eight case studies. Neuromodulation: J Int Neuromodulation Soc. 2006;9(1):41–7.

    Article  Google Scholar 

  61. Slavin KV, Nersesyan H, Wess C. Peripheral neurostimulation for treatment of intractable occipital neuralgia. Neurosurgery. 2006;58(1):112–9; discussion −9.

    Google Scholar 

  62. Magis D. Neuromodulation in migraine: state of the art and perspectives. Expert Rev Med Devices. 2015;12(3):329–39.

    Article  CAS  PubMed  Google Scholar 

  63. Sharan A, Huh B, Narouze S, Trentman T, Mogilner A, Vaisman J, et al. Analysis of adverse events in the management of chronic migraine by peripheral nerve stimulation. Neuromodulation: J Int Neuromodulation Soc. 2015;18(4):305–12.

    Article  Google Scholar 

  64. Palmisani S, Al-Kaisy A, Arcioni R, Smith T, Negro A, Lambru G, et al. A six year retrospective review of occipital nerve stimulation practice–controversies and challenges of an emerging technique for treating refractory headache syndromes. J Headache Pain. 2013;14:67.

    Article  PubMed  PubMed Central  Google Scholar 

  65. Magis D, Schoenen J. Advances and challenges in neurostimulation for headaches. Lancet Neurol. 2012;11(8):708–19.

    Article  PubMed  Google Scholar 

  66. Schwedt TJ, Dodick DW, Trentman TL, Zimmerman RS. Occipital nerve stimulation for chronic cluster headache and hemicrania continua: pain relief and persistence of autonomic features. Cephalalgia: Int J Headache. 2006;26(8):1025–7.

    Article  CAS  Google Scholar 

  67. Martelletti P, Jensen RH, Antal A, Arcioni R, Brighina F, de Tommaso M, et al. Neuromodulation of chronic headaches: position statement from the European Headache Federation. J Headache Pain. 2013;14(1):86.

    Article  PubMed  PubMed Central  Google Scholar 

  68. Leone M, Proietti Cecchini A, Mea E, D’Amico D, Tullo V, Grazzi L, et al. Therapeutic neurostimulation in chronic headaches: problems of patient selection. Neurol Sci: Off J Italian Neurol Soc Italian Soc Clin Neurophysiol. 2008;29(Suppl 1):S59–61.

    Article  Google Scholar 

  69. Schoenen J, Jensen RH, Lanteri-Minet M, Lainez MJ, Gaul C, Goodman AM, et al. Stimulation of the sphenopalatine ganglion (SPG) for cluster headache treatment. Pathway CH-1: a randomized, sham-controlled study. Cephalalgia: Int J Headache. 2013;33(10):816–30.

    Article  Google Scholar 

  70. Jurgens TP, Schoenen J, Rostgaard J, Hillerup S, Lainez MJ, Assaf AT, et al. Stimulation of the sphenopalatine ganglion in intractable cluster headache: expert consensus on patient selection and standards of care. Cephalalgia: Int J Headache. 2014;34:1100–10.

    Article  Google Scholar 

  71. Bahra A, Matharu MS, Buchel C, Frackowiak RS, Goadsby PJ. Brainstem activation specific to migraine headache. Lancet. 2001;357(9261):1016–7.

    Article  CAS  PubMed  Google Scholar 

  72. May A. A review of diagnostic and functional imaging in headache. J Headache Pain. 2006;7(4):174–84.

    Article  PubMed  PubMed Central  Google Scholar 

  73. Leone M, Franzini A, Bussone G. Stereotactic stimulation of posterior hypothalamic gray matter in a patient with intractable cluster headache. N Engl J Med. 2001;345:1428–9.

    Article  CAS  PubMed  Google Scholar 

  74. Matharu MS, Zrinzo L. Deep brain stimulation in cluster headache: hypothalamus or midbrain tegmentum? Curr Pain Headache Rep. 2010;14(2):151–9.

    Article  PubMed  Google Scholar 

  75. Schoenen J, Di Clemente L, Vandenheede M, Fumal A, De Pasqua V, Mouchamps M, et al. Hypothalamic stimulation in chronic cluster headache: a pilot study of efficacy and mode of action. Brain J Neurol. 2005;128(Pt 4):940–7.

    Article  CAS  Google Scholar 

  76. Franzini A, Messina G, Cordella R, Marras C, Broggi G. Deep brain stimulation of the posteromedial hypothalamus: indications, long-term results and neurophysiological considerations. Neurosurg Focus. 2010;29(2):1–13.

    Article  Google Scholar 

  77. Seijo F, Saiz A, Lozano B, Santamarta E, Alvarez-Vega M, Seijo E, et al. Neuromodulation of the posterolateral hypothalamus for the treatment of chronic refractory cluster headache: experience in five patients with a modified anatomical target. Cephalalgia: Int J Headache. 2011;31(16):1634–41.

    Article  CAS  Google Scholar 

  78. Bartsch T, Pinsker MO, Rasche D, et al. Hypothalamic deep brain stimulation for cluster headache: experience from a new multicase series. Cephalalgia: Int J Headache. 2008;28:285–95.

    Article  CAS  Google Scholar 

  79. Fontaine D, Lazorthes Y, Mertens P, Blond S, Geraud G, Fabre N, et al. Safety and efficacy of deep brain stimulation in refractory cluster headache: a randomized placebo-controlled double-blind trial followed by a 1-year open extension. J Headache Pain. 2010;11(1):23–31.

    Article  CAS  PubMed  Google Scholar 

  80. Leone M, Franzini A, Proietti Cecchini A, Bussone G. Success, failure, and putative mechanisms in hypothalamic stimulation for drug-resistant chronic cluster headache. Pain. 2013;154(1):89–94.

    Article  PubMed  Google Scholar 

  81. Starr PA, Barbaro NM, Raskin NH, Ostrem JL. Chronic stimulation of the posterior hypothalamus region for cluster headache: technique and 1-year results in four patients. J Neurosurg. 2007;106:999–1005.

    Article  PubMed  Google Scholar 

  82. Lyons MK, Dodick DW, Evidente VG. Responsiveness of short-lasting unilateral neuralgiform headache with conjunctival injection and tearing to hypothalamic deep brain stimulation. J Neurosurg. 2009;110(2):279–81.

    Article  PubMed  Google Scholar 

  83. Miller S, Rasul F, Lambru G, Lagrata S, Hariz GM, Zrinzo L, et al. Posterior hypothalamic region deep brain stimulation in shoer lasting unilateral neuralgiform headache with conjunctival injection and tearing (SUNCT). Cephalalgia: Int J Headache. 2013;33(8 Suppl):1–309.

    Google Scholar 

  84. Bartsch T, Falk D, Knudsen K, Reese R, Raethjen J, Mehdorn HM, et al. Deep brain stimulation of the posterior hypothalamic area in intractable short-lasting unilateral neuralgiform headache with conjunctival injection and tearing (SUNCT). Cephalalgia: Int J Headache. 2011;31(13):1405–8.

    Article  CAS  Google Scholar 

  85. Leone M, Franzini A, D'Andrea G, Broggi G, Casucci G, Bussone G. Deep brain stimulation to relieve drug-resistant SUNCT. Ann Neurol. 2005;57(6):924–7.

    Article  PubMed  Google Scholar 

  86. Leone M, Franzini A, Broggi G, Mea E, Cecchini AP, Bussone G. Acute hypothalamic stimulation and ongoing cluster headache. Neurology. 2006;67:1844–5.

    Article  CAS  PubMed  Google Scholar 

  87. Lipton RB, Dodick DW, Silberstein SD, Saper JR, Aurora SK, Pearlman SH, et al. Single-pulse transcranial magnetic stimulation for acute treatment of migraine with aura: a randomised, double-blind, parallel-group, sham-controlled trial. Lancet Neurol. 2010;9(4):373–80.

    Article  PubMed  Google Scholar 

  88. Bhola R, Kinsella E, Giffin N, Lipscombe S, Ahmed F, Weatherall M, et al. Single-pulse transcranial magnetic stimulation (sTMS) for the acute treatment of migraine: evaluation of outcome data for the UK post market pilot program. J Headache Pain. 2015;16:535.

    Article  PubMed  Google Scholar 

  89. Dodick DW, Schembri CT, Helmuth M, Aurora SK. Transcranial magnetic stimulation for migraine: a safety review. Headache. 2010;50(7):1153–63.

    Article  PubMed  Google Scholar 

  90. Matharu MS, Bartsch T, Ward N, Frackowiak RS, Weiner R, Goadsby PJ. Central neuromodulation in chronic migraine patients with suboccipital stimulators: a PET study. Brain J Neurol. 2004;127(Pt 1):220–30.

    Article  Google Scholar 

  91. Kovacs S, Peeters R, De Ridder D, Plazier M, Menovsky T, Sunaert S. Central effects of occipital nerve electrical stimulation studied by functional magnetic resonance imaging. Neuromodulation: Technol Neural Interface. 2011;14(1):46–57.

    Article  Google Scholar 

  92. Magis D, Bruno MA, Fumal A, Gerardy PY, Hustinx R, Laureys S, et al. Central modulation in cluster headache patients treated with occipital nerve stimulation: an FDG-PET study. BMC Neurol. 2011;11:25.

    Article  PubMed  PubMed Central  Google Scholar 

  93. Kraus T, Kiess O, Hosl K, Terekhin P, Kornhuber J, Forster C. CNS BOLD fMRI effects of sham-controlled transcutaneous electrical nerve stimulation in the left outer auditory canal – a pilot study. Brain Stimul. 2013;6(5):798–804.

    Article  PubMed  Google Scholar 

  94. Holland PR, Schembri CT, Fredrick J, Goadsby P. Transcranial magnetic stimulation for the treamtent of migraine aura? Cephalalgia: Int J Headache. 2009;29(1 suppl):22.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Manjit S. Matharu FRCP, PhD .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2017 Springer International Publishing AG

About this chapter

Cite this chapter

Miller, S., Matharu, M.S. (2017). The Use of Electroceuticals and Neuromodulation in the Treatment of Migraine and Other Headaches. In: Majid, A. (eds) Electroceuticals. Springer, Cham. https://doi.org/10.1007/978-3-319-28612-9_1

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-28612-9_1

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-28610-5

  • Online ISBN: 978-3-319-28612-9

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics