Abstract
In legal medicine in particular, it is critical to establish that a forensic medical procedure does not induce alterations at the cellular or histomorphologic levels because histopathologic findings may be helpful or even evidentiary in determining the cause of death [1–3]. Injection of contrast agent into a body carries the risk of causing several artefacts at the histomorphologic level [4, 5]. Therefore, investigations are necessary that lead to descriptions of such artefacts to avoid misinterpretation, especially because artefacts are specific for each angiography method. To date, a detailed analysis of such artefacts has been initiated only for the technique of multiphase postmortem computed tomography angiography (MPMCTA) [6]. Further investigations including different techniques, and contrast agents are essential.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsReferences
Brinkmann B. Harmonization of medico-legal autopsy rules. Committee of Ministers. Council of Europe. Int J Legal Med. 1999;113:1–14.
de la Grandmaison GL, Charlier P, Durigon M. Usefulness of systematic histological examination in routine forensic autopsy. J Forensic Sci. 2010;55:85–8.
Dettmeyer RB. The role of histopathology in forensic practice: an overview. Forensic Sci Med Pathol. 2014;10:401–12.
Michaud K, Grabherr S, Jackowski C, Bollmann MD, Doenz F, Mangin P. Postmortem imaging of sudden cardiac death. Int J Legal Med. 2014;128:127–37.
Morgan B, Biggs MJ, Barber J, Raj V, Amoroso J, Hollingbury FE, et al. Accuracy of targeted post-mortem computed tomography coronary angiography compared to assessment of serial histological sections. Int J Legal Med. 2013;127:809–17.
Grabherr S, Doenz F, Steger B, Dirnhofer R, Dominguez A, Sollberger B, et al. Multi-phase post-mortem CT angiography: development of a standardized protocol. Int J Legal Med. 2011;125:791–802.
Dettmeyer RB. Forensic histopathology: fundamentals and perspectives. Berlin/Heidelberg: Springer; 2011.
Mulisch M, Welsch U, editors. Romeis Mikroskopische Technik. Heidelberg: Spektrum Akademischer Verlag; 2010.
Michaud K, Grabherr S, Doenz F, Mangin P. Evaluation of postmortem MDCT and MDCT-angiography for the investigation of sudden cardiac death related to atherosclerotic coronary artery disease. Int J Cardiovasc Imaging. 2012;28:1807–22.
Grabherr S, Djonov V, Friess A, Thali MJ, Ranner G, Vock P, et al. Postmortem angiography after vascular perfusion with diesel oil and a lipophilic contrast agent. Am J Roentgenol. 2006;187:W515–23.
Jackowski C, Bolliger S, Aghayev E, Christe A, Kilchoer T, Aebi B, et al. Reduction of postmortem angiography-induced tissue edema by using polyethylene glycol as a contrast agent dissolver. J Forensic Sci. 2006;51:1134–7.
Sperhake J, Einfeldt E, Türk E. Leichenliegezeit 59 Jahre und 261 Tage. Untersuchung eines Flugzeugabsturzes aus dem Zweiten Weltkrieg. [Postmortem interval 59 years and 261 days. Investigation of an airplane crash from World War II]. Rechtsmedizin. 2004;14:20–3.
Schneider B, Chevallier C, Dominguez A, Bruguier C, Elandoy C, Mangin P, et al. The forensic radiographer: a new member in the medicolegal team. Am J Forensic Med Pathol. 2012;33:30–6.
Palmiere C, Lobrinus JA, Mangin P, Grabherr S. Detection of coronary thrombosis after multi-phase postmortem CT-angiography. Legal Med (Tokyo, Japan). 2013;15:12–8.
Zagorchev L, Oses P, Zhuang Z, Moodie K, Mulligan-Kehoe M, Simons M, et al. Micro computed tomography for vascular exploration. J Angiogen Res. 2010;2:1–11.
Capuani C, Guilbeau-Frugier C, Mokrane FZ, Delisle MB, Marcheix B, Rousseau H, et al. Tissue microscopic changes and artifacts in multi-phase post-mortem computed tomography angiography in a hospital setting: a fatal case of systemic vasculitis. Forensic Sci Int. 2014;242:e12–7.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2016 Springer International Publishing Switzerland
About this chapter
Cite this chapter
Wittig, H., Stumm, C., Eplinius, F., Hecht, L. (2016). Histology After Postmortem Angiography. In: Grabherr, S., Grimm, J., Heinemann, A. (eds) Atlas of Postmortem Angiography. Springer, Cham. https://doi.org/10.1007/978-3-319-28537-5_29
Download citation
DOI: https://doi.org/10.1007/978-3-319-28537-5_29
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-28535-1
Online ISBN: 978-3-319-28537-5
eBook Packages: MedicineMedicine (R0)