Oxygen Modulation and Bronchopulmonary Dysplasia: Delivery Room and Beyond

  • Isabel Torres-Cuevas
  • María Cernada
  • Antonio Nuñez
  • Maximo VentoEmail author
Part of the Respiratory Medicine book series (RM)


Low oxygen concentration in utero drives lung vascular and alveolar development. Preterm birth implies an abrupt increase in the availability of oxygen to tissue. As a consequence, transcription factors responsible to activate genes that promote vascular growth and alveolar development will be downregulated causing impairment in lung development and subsequent respiratory insufficiency. Therefore, preterm infants, especially those <32 weeks gestation, will need positive pressure ventilation and oxygen supplementation immediately after birth and thereafter in the neonatal intensive care unit (NICU). In addition, preterm infants are endowed with an immature antioxidant defense system which predisposes to oxidative stress that will cause structural and functional damage and inflammation finally leading to bronchopulmonary dysplasia (BPD). Herewith, this chapter summarizes the present recommendations for oxygen supplementation aiming to reducing one of the essential factors contributing to the development and severity of this condition.


Bronchopulmonary dysplasia Oxygen Oxidative stress Pulseoximetry Reactive oxygen species Resuscitation Oxygen saturation range 


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Copyright information

© Springer International Publishing Switzerland 2016

Authors and Affiliations

  • Isabel Torres-Cuevas
    • 1
  • María Cernada
    • 1
  • Antonio Nuñez
    • 1
  • Maximo Vento
    • 1
    • 2
    Email author
  1. 1.Health Research Institute La Fe, Neonatal Research GroupValenciaSpain
  2. 2.Division of NeonatologyUniversity and Polytechnic Hospital La FeValenciaSpain

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