Abstract
Proteases (PRs) catalyze the cleavage of peptide bonds by hydrolysis in proteins and peptides playing crucial functions in organisms all over the phylogenetic tree. These enzymes are present in all types of bacteria and are involved in critical processes such as acquisition of nutrients for growth and proliferation, facilitation of dissemination, colonization and evasion of host immune defenses or tissue damage during infection. Bacterial pathogens use their PRs to acquire or activate the function of host PRs to help them in their growth or progression of disease. Research into bacterial PRs and their substrates will allow the development of novel PRs inhibiting compounds that could potentially be used to limit host virulence or to block cell growth. The emergence resistances to traditional antibiotics have created clinical difficulties for nosocomial treatment on a global scale. Thus the pharmacological development of new PRs inhibitors that target essential proteins in the bacterial pathogen is of great interest, and it is the focus of this review.
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Acknowledgments
The authors want to thank the European Union (FP7-ENVIRONMENT 2012-two-stage (BIOCORIN, project reference: 28288) and the Spanish Ministry of Economy and Competitively (Madrid, Spain) [Subprogramme for Non-Guided Fundamental Research Projects 2012 (FAES, project reference: CTM2012-320269)].
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Ullán, R.V., Barreiro, C. (2016). Bacterial Proteases as Targets to Control Bacterial Growth. In: Villa, T., Vinas, M. (eds) New Weapons to Control Bacterial Growth. Springer, Cham. https://doi.org/10.1007/978-3-319-28368-5_7
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