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Fecal Matter Implantation as a Way to Fight Diarrhea-Causing Microorganisms

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New Weapons to Control Bacterial Growth

Abstract

This chapter summarizes the current knowledge about fecal microbiota transplantation (FMT) as a way to treat persistent diarrhea. Although this is an old concept, originated in China at least a millennium ago, it also represents a novel approach and an alternative to the use of antibiotics. This approach is a major departure from Paul Ehrlich´s old paradigm ‘the magic bullet,’ or a compound that supplied in a ‘dossa sterilisa magna’ would eliminate the parasite protozoan or bacterium, and represents a more ecological perspective in the fight against pathogenic microorganisms. This chapter includes additional topics, such as the effect of probiotics and ADP-ribosylation, as well as cAMP, cGMP, and phosphatidylinositol signaling. We also deal here with the problems associated with fecal transplant therapies when using human stool donors that, although asymptomatic, are in fact carriers of bacterial or parasite diseases.

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Authors and Affiliations

  1. Faculty of Pharmacy, Department of Microbiology, Biotechnology Unit, University of Santiago de Compostela, Santiago, 15706, Spain

    Tomás G. Villa, Lucía Feijoo-Siota, José Luis R. Rama & Trinidad de Miguel-Bouzas

  2. Discipline of Physiology and Bosch Institute, School of Medical Sciences, University of Sydney, Sydney, NSW, 2006, Australia

    Angeles Sánchez-Pérez

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  1. Tomás G. Villa
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  2. Lucía Feijoo-Siota
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  3. José Luis R. Rama
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  4. Angeles Sánchez-Pérez
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  5. Trinidad de Miguel-Bouzas
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Correspondence to Tomás G. Villa .

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  1. Faculty of Pharmacy, University of Santiago de Compostel, Santiago de Compostela, Spain

    Tomas G. Villa

  2. Faculty of Medicine, University of Barcelona, L'Hospitalet de Llobregat, Spain

    Miguel Vinas

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Villa, T.G., Feijoo-Siota, L., Rama, J.L.R., Sánchez-Pérez, A., de Miguel-Bouzas, T. (2016). Fecal Matter Implantation as a Way to Fight Diarrhea-Causing Microorganisms. In: Villa, T., Vinas, M. (eds) New Weapons to Control Bacterial Growth. Springer, Cham. https://doi.org/10.1007/978-3-319-28368-5_13

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