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Platelet Transfusion

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Trauma Induced Coagulopathy

Abstract

Platelet (PLT) biology is deceptively complicated. From a morphological aspect, the elegant discoid shape of the resting platelet belies the intricate cytoskeleton and convoluted tubular systems that enable spectacular shape change upon activation. The evolution of platelet products and their use in transfusion is similarly convoluted and requires an immersion in history to understand. As described below, the current state of the art in platelet transfusion rests on surprisingly little robust clinical data, minimal efforts to tailor product characteristics to patient needs, and a regulatory framework that supports the inadequate status quo. Development of new platelet products and optimal transfusion strategies for bleeding patients represent opportunities for major advances in surgical care.

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Authors and Affiliations

  1. US Army Institute of Surgical Research, 3650 Chambers Pass, JBSA-FT Sam Houston, TX, 78234, USA

    Andrew P. Cap M.D., Ph.D., F.A.C.P.

  2. Cellphire Inc., Rockville, MD, USA

    Todd M. Getz Ph.D.

  3. Department of Pediatrics, Division of Critical Care Medicine, School of Medicine, Washington University in St. Louis, St. Louis, MO, USA

    Philip C. Spinella M.D., F.C.C.M.

  4. Terumo BCT Biotechnologies, LLC, Lakewood, CO, USA

    Heather F. Pidcoke M.D., Ph.D.

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  1. Andrew P. Cap M.D., Ph.D., F.A.C.P.
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  2. Todd M. Getz Ph.D.
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  3. Philip C. Spinella M.D., F.C.C.M.
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  4. Heather F. Pidcoke M.D., Ph.D.
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Correspondence to Andrew P. Cap M.D., Ph.D., F.A.C.P. .

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Editors and Affiliations

  1. Dept of Surgery & Trauma Research Center, Univ of Colorado School of Medicine, Aurora, Colorado, USA

    Eduardo Gonzalez

  2. Dept of Surgery & Trauma Research Center, Univ of Colorado School of Medicine, Aurora, Colorado, USA

    Hunter B. Moore

  3. Dept of Surgery & Trauma Research Center, Univ of Colorado Sch of Med&Denver Healt, Denver, Colorado, USA

    Ernest E. Moore

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Cap, A.P., Getz, T.M., Spinella, P.C., Pidcoke, H.F. (2016). Platelet Transfusion. In: Gonzalez, E., Moore, H., Moore, E. (eds) Trauma Induced Coagulopathy. Springer, Cham. https://doi.org/10.1007/978-3-319-28308-1_22

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