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The Complement System and Coagulation

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Trauma Induced Coagulopathy

Abstract

Severe trauma, commonly followed by substantial blood loss and sepsis, represents a major cause of mortality and morbidity in emergency and intensive care units. Massive activation of the hemostatic and complement systems is a common denominator of trauma and sepsis. While local activation of these proteolytic cascades contributes to the host defense, their uncontrolled systemic activation has major tissue-damaging effects that lead to multiple organ failure and death. This chapter reviews the molecular pathways of complement activation and the regulatory mechanisms controlling the formation of the terminal cytolytic complex C5b-9, and the signaling events triggered by the complement-derived anaphylatoxins. The cross talk between complement and coagulation and the contribution of these pathways to the integrated host response to vascular injury and sepsis are discussed.

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  1. Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK, 73104, USA

    Narcis I. Popescu & Florea Lupu

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  1. Narcis I. Popescu
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  2. Florea Lupu
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Correspondence to Florea Lupu .

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  1. Dept of Surgery & Trauma Research Center, Univ of Colorado School of Medicine, Aurora, Colorado, USA

    Eduardo Gonzalez

  2. Dept of Surgery & Trauma Research Center, Univ of Colorado School of Medicine, Aurora, Colorado, USA

    Hunter B. Moore

  3. Dept of Surgery & Trauma Research Center, Univ of Colorado Sch of Med&Denver Healt, Denver, Colorado, USA

    Ernest E. Moore

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Popescu, N.I., Lupu, F. (2016). The Complement System and Coagulation. In: Gonzalez, E., Moore, H., Moore, E. (eds) Trauma Induced Coagulopathy. Springer, Cham. https://doi.org/10.1007/978-3-319-28308-1_12

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