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Trauma Induced Coagulopathy pp 167–171Cite as

DAMPs: Damage-Associated Molecular Pattern Molecules in Hemostasis

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Abstract

This chapter explores the role of some of the key DAMPs in modulating the coagulation and fibrinolytic cascades, how they activate platelets, and modulate platelet functions. Potential mechanisms differentiating disseminated intravascular coagulation from thrombosis are discussed with an emphasis on the generation of procoagulant membrane remnants that do or do not have adhesion molecules associated with them as a likely candidate for differential responses.

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Author information

Authors and Affiliations

  1. Coagulation Biology Laboratory, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK, 73104, USA

    Charles T. Esmon Ph.D.

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  1. Charles T. Esmon Ph.D.
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Correspondence to Charles T. Esmon Ph.D. .

Editor information

Editors and Affiliations

  1. Dept of Surgery & Trauma Research Center, Univ of Colorado School of Medicine, Aurora, Colorado, USA

    Eduardo Gonzalez

  2. Dept of Surgery & Trauma Research Center, Univ of Colorado School of Medicine, Aurora, Colorado, USA

    Hunter B. Moore

  3. Dept of Surgery & Trauma Research Center, Univ of Colorado Sch of Med&Denver Healt, Denver, Colorado, USA

    Ernest E. Moore

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© 2016 Springer International Publishing Switzerland

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Esmon, C.T. (2016). DAMPs: Damage-Associated Molecular Pattern Molecules in Hemostasis. In: Gonzalez, E., Moore, H., Moore, E. (eds) Trauma Induced Coagulopathy. Springer, Cham. https://doi.org/10.1007/978-3-319-28308-1_11

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  • DOI: https://doi.org/10.1007/978-3-319-28308-1_11

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-28306-7

  • Online ISBN: 978-3-319-28308-1

  • eBook Packages: MedicineMedicine (R0)

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