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Radiobiology of Glioblastoma pp 139–153Cite as

Basic Knowledge of Glioblastoma Radiobiology

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Part of the book series: Current Clinical Pathology ((CCPATH))

Abstract

Glioblastoma (GBM) is radioresistant tumors with an infaust prognosis. Local disease control is the main intent of treatment because of the high incidence of recurrence. Radiotherapy post surgical resection is the mainstay of the management of GBM; however, high dose treatments fail to improve survival. Major determinants of radioresistance are here reviewed. GBM is characterized by genomic heterogeneity intra- and intertumors. GBM cells can present dysregulation of genes involved in main sensors and effectors of DNA damage, DNA repair, cell cycle regulation, apoptosis, and signaling pathways. High expression of growth factor can affect response to radiation, as well as angiogenesis, hypoxia and presence of cancer stem cells can increase radioresistance. High expression of extracellular matrix degrading enzymes and of transcription factors master regulators of epithelial mesenchymal transition support invasiveness and diffuse infiltration. A good knowledge of basic radiobiology of GBM can help in finding new therapeutic targets.

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Authors and Affiliations

  1. Radiotherapy Unit, Department of Experimental and Clinical Biomedical Sciences, University of Florence, Largo Brambilla 3, 50134, Firenze, Italy

    Monica Mangoni, Mariangela Sottili, Chiara Gerini & Lorenzo Livi

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  1. Monica Mangoni
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  2. Mariangela Sottili
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  3. Chiara Gerini
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  4. Lorenzo Livi
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Correspondence to Monica Mangoni .

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Editors and Affiliations

  1. University of Siena, Sec. of Radiation Oncology,Dept. of Med., Siena, Italy

    Luigi Pirtoli

  2. Dept. of Applied Clinical & Biotech Sci., University of L’Aquila, L’Aquila, Italy

    Giovanni Luca Gravina

  3. Department of Biology, Temple University, Philadelphia, Pennsylvania, USA

    Antonio Giordano

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Mangoni, M., Sottili, M., Gerini, C., Livi, L. (2016). Basic Knowledge of Glioblastoma Radiobiology. In: Pirtoli, L., Gravina, G., Giordano, A. (eds) Radiobiology of Glioblastoma. Current Clinical Pathology. Humana Press, Cham. https://doi.org/10.1007/978-3-319-28305-0_9

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  • DOI: https://doi.org/10.1007/978-3-319-28305-0_9

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  • Publisher Name: Humana Press, Cham

  • Print ISBN: 978-3-319-28303-6

  • Online ISBN: 978-3-319-28305-0

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