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Clinical Evidence and Radiobiological Background of Particle Radiation Therapy

  • Walter TinganelliEmail author
  • Marco Durante
  • Alexander Helm
Chapter
  • 629 Downloads
Part of the Current Clinical Pathology book series (CCPATH)

Abstract

Charged particle therapy compared to the conventional radiotherapy offers many advantages. The particles’ peculiar inversed dose-depth profile characteristics provide the possibility, contrarily to photon irradiation, to deposit the energy more precisely to the tumour leading to a higher tumour local control, a lower probability to damage the surrounding healthy tissue and a lower risk of complications.

Particle therapy thus is helpful especially for the most radioresistant tumours or for those neoplasms prognosed too difficult to eradicate with surgery due to the position in anatomical sites where the access is limited.

The few clinical trials performed until now indicate that carbon ion treatment has the potential to completely replace conventional radiotherapy and in many cases surgery as well.

Furthermore, recent studies intend to elucidate the possibility to treat cancer using ions different from carbon and proton such as lithium or oxygen.

Increasing evidence prompts the promising potential of particle therapy; however, the cost-benefit ratio remains controversial and thus particle therapy still remains to be applied exclusively in a few states around the world. Current studies in radiobiology and medical physics focus on cost reduction as well as an increase in the benefit of this treatment.

Keywords

Overall Survival Glioblastoma Multiforme Intensity Modulate Radiation Therapy Linear Energy Transfer Relative Biological Effectiveness 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer International Publishing Switzerland 2016

Authors and Affiliations

  • Walter Tinganelli
    • 1
    • 2
    Email author
  • Marco Durante
    • 1
    • 2
  • Alexander Helm
    • 1
    • 2
  1. 1.Helmholtzzentrum für Schwerionenforschung GmbH (GSI)DarmstadtGermany
  2. 2.Trento Institute for Fundamental Physics and Applications (TIFPA)TrentoItaly

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