Cell Death Pathways, with Special Regard to Ionizing Radiation and Temozolomide

  • Marzia ToscanoEmail author
  • Silvia Palumbo
  • Paolo Tini
  • Clelia Miracco
  • Giovanni Luca Gravina
  • Sergio Comincini
Part of the Current Clinical Pathology book series (CCPATH)


Tumor cell death is the final goal of both radio- and chemotherapy. For several decades, apoptosis has been considered as the principal type of programmed cell death (PCD) in mammalian tissues. Resistance to apoptosis was closely linked to tumorigenesis, and has taken a central position in cell death research. However, in the last years it has become evident that radiotherapy as well as other therapeutic agents, including temozolomide (TMZ) are able to elicit non-apoptotic pathways of PCD, which are not always mutually exclusive, as thought in the past.In this chapter we will address this topic, focusing on apoptosis and autophagy-related cell death in cancer, their induction by IR and TMZ, and implication in glioblastoma (GB) treatment.We will review currently known mechanisms of both IR and TMZ in inducing cell death, the possibility to modulate PCD as well as other approaches which will open new perspectives for improving the efficacy of therapy in GB.


Programme Cell Death Ionize Radiation Arsenic Trioxide Tumor Cell Death Autophagic Cell Death 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer International Publishing Switzerland 2016

Authors and Affiliations

  • Marzia Toscano
    • 1
    • 2
    Email author
  • Silvia Palumbo
    • 2
  • Paolo Tini
    • 1
    • 3
  • Clelia Miracco
    • 4
  • Giovanni Luca Gravina
    • 5
  • Sergio Comincini
    • 6
  1. 1.Tuscany Tumor InstituteFlorenceItaly
  2. 2.Unit of Radiation Oncology, Department of MedicineSurgery and Neurosciences University of SienaSienaItaly
  3. 3.Unit of Radiation OncologyUniversity Hospital of Siena (Azienda Ospedaliera-Universitaria Senese)SienaItaly
  4. 4.Unit of Pathological Anatomy, Department of Medicine, Surgery and NeurosciencesUniversity of SienaSienaItaly
  5. 5.Department of Radiological, Oncological and Anatomo-Pathological SciencesUniversity of Rome “La Sapienza”RomeItaly
  6. 6.Department of Biology and BiotechnologyUniversity of PaviaPaviaItaly

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