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Radiobiology of Glioblastoma pp 189–207Cite as

Tumor Microenvironment, Hypoxia, and Stem Cell-Related Radiation Resistance

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Part of the book series: Current Clinical Pathology ((CCPATH))

Abstract

Resistance to therapy of glioblastoma is attributable to cellular and phenotypical heterogeneity. Increasing evidence supports the hypothesis that the intratumoral heterogeneity derives from a combination of genetic/epigenetic events and of a cellular hierarchy dominated by a subpopulation of cells exhibiting stem cell properties, named glioblastoma stem cells (GSCs). Growing body of data accounts for GSCs role in initiation, progression, and radioresistance of glioblastoma.

In addition multiple interactions between tumor cells and microenvironment contribute to tumor progression. Microenvironment cells can secrete a number of factors, such as growth factors and chemokines, that play a vital role in controlling the course of pathology. A better knowledge of microenvironment biology could help to develop new targeted therapies able to sensitize glioblastoma to radiation, in order to overcome treatment resistance, and would be useful also for the optimization of radiotherapy treatment planning.

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Authors and Affiliations

  1. Radiotherapy Unit, Department of Experimental and Clinical Biomedical Sciences, University of Florence, Largo Brambilla 3, Firenze, 50134, Italy

    Mariangela Sottili, Chiara Gerini, Isacco Desideri, Mauro Loi, Lorenzo Livi & Monica Mangoni

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  1. Mariangela Sottili
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  2. Chiara Gerini
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  3. Isacco Desideri
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  4. Mauro Loi
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  5. Lorenzo Livi
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  6. Monica Mangoni
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Correspondence to Monica Mangoni .

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Editors and Affiliations

  1. University of Siena, Sec. of Radiation Oncology,Dept. of Med., Siena, Italy

    Luigi Pirtoli

  2. Dept. of Applied Clinical & Biotech Sci., University of L’Aquila, L’Aquila, Italy

    Giovanni Luca Gravina

  3. Department of Biology, Temple University, Philadelphia, Pennsylvania, USA

    Antonio Giordano

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Sottili, M., Gerini, C., Desideri, I., Loi, M., Livi, L., Mangoni, M. (2016). Tumor Microenvironment, Hypoxia, and Stem Cell-Related Radiation Resistance. In: Pirtoli, L., Gravina, G., Giordano, A. (eds) Radiobiology of Glioblastoma. Current Clinical Pathology. Humana Press, Cham. https://doi.org/10.1007/978-3-319-28305-0_12

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  • DOI: https://doi.org/10.1007/978-3-319-28305-0_12

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