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Regenerative Medicine - from Protocol to Patient pp 1–19Cite as

History of Regenerative Medicine

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Abstract

Generation and regeneration as an answer to disease are far from being a new idea. Philosophers, naturalists and scientists were intrigued by the marvels of regeneration seen in nature. By the middle of the nineties life scientists thought we were only a few years away from bioartificial organs grown in a Petri dish. However, by the dawn of the new millennium it became clear that the mechanistic approach dictated by tissue engineering so far, had neglected issues of vascularization. Processes of angiogenesis were central to homeostasis, bioassimilation and biointegration of tissue engineered constructs. Furthermore, the field of tissue engineering had evolved into something vast, encompassing satellite technologies that were becoming separate science sectors. Advances in genetical engineering, stem cell biology, cloning, biomaterials and biomedical devices to name a few, would come to play a major role of their own – tissue engineering had become a part of a bigger whole. Regenerative medicine is the collective field to shelter these technologies “…that seeks to develop functional cell, tissue, and organ substitutes to repair, replace or enhance biological function that has been lost due to congenital abnormalities, injury, disease, or aging”.

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Notes

  1. 1.

    Now the phenomenon of desquamation of the intestinal epithelium and the epidermis has been described. The intestinal epithelium is completely regenerated in 4–5 days. The total regeneration of the epidermis takes 4 weeks. This may mean that for a life expectancy of 77 years, the human epidermis is regenerated 1000 times.

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Authors and Affiliations

  1. Plastisch und Handchirurgische Klinik, Universitätsklinikum Erlangen, Friedrich Alexander Universität Erlangen-Nürnberg FAU, Krankenhausstrasse 12, D-91054, Erlangen, Germany

    Raymund E. Horch & Elias Polykandriotis

  2. Division of Advanced Studies Institute, “Victor Babeș” National Institute of Pathology, University of Medicine and Pharmacy, Bucharest, Romania

    Laurentiu M. Popescu

Authors
  1. Raymund E. Horch
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  2. Laurentiu M. Popescu
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  3. Elias Polykandriotis
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Correspondence to Raymund E. Horch .

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Editors and Affiliations

  1. KIlinik und Poliklinik für Herzchirurgie, Universitätsmedizin Rostock, Rostock, Mecklenburg-Vorpomm., Germany

    Gustav Steinhoff

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Horch, R.E., Popescu, L.M., Polykandriotis, E. (2016). History of Regenerative Medicine. In: Steinhoff, G. (eds) Regenerative Medicine - from Protocol to Patient. Springer, Cham. https://doi.org/10.1007/978-3-319-28293-0_1

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