Abstract
The human epidermal growth factor receptor 2 (HER2) is a transmembrane tyrosine kinase that is overexpressed in approximately 20% of invasive breast cancers, primarily due to gene amplification [1]. Over the last 15 years, several HER2-targeted therapies have been developed and have significantly improved the outcome of patients with metastatic breast cancer (MBC).
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Alvarez, R.H. (2016). HER2-positive metastatic breast cancer: second-line treatment. In: Handbook of HER2-Targeted Agents in Breast Cancer. Adis, Cham. https://doi.org/10.1007/978-3-319-28216-9_5
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DOI: https://doi.org/10.1007/978-3-319-28216-9_5
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