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Permeability of Membranes

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Permeability of Biological Membranes

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Abstract

This chapter provides an overview of bilayer permeability and selectivity of permeabilization. Based on the hydrophobic nature of the lipid bilayer, cell membranes behave as diffusion barriers primarily for electrolytes, hydrophilic micro- and macromolecules in solutions. To overcome the permeability barrier different transport processes have been evolved for crossing the cell membrane. Small particles may be transported by passive transport, active transport or by carriers. To transport large particles through the membrane different strategies have been developed involving exocytosis, endocytosis and receptor mediated endocytosis. The importance of permeability is underlined by the integrity of cell membrane in maintaining the viability of cells. Different approaches have been applied to investigate membrane permeability as a measure of viability, by detecting permeability on account of hemolysis, turbidimetry and release of lactate dehydrogenase.

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  1. University of Debrecen, Debrecen, Hungary

    Gaspar Banfalvi

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Banfalvi, G. (2016). Permeability of Membranes. In: Permeability of Biological Membranes. Springer, Cham. https://doi.org/10.1007/978-3-319-28098-1_2

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