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Point-of-Care Clinical Guide: Gallbladder Cancer

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Pancreas and Biliary Disease

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Abstract

Gallbladder cancer is an uncommon disease that carries a high mortality rate due to its often late presentation. The disease follows a slow steady asymptomatic growth, and may be discovered incidentally at an earlier stage during a cholecystectomy. Gallbladder cancer possesses an infiltrating growth pattern towards the neighboring portal vasculature. Nihilistic view of the disease stayed for years due to patients’ limited survival. Recent studies report a decline in mortality rates in several parts of the world, although survival remains dismal for advanced stages. Gallbladder cancer is more commonly seen in South American countries such as Chile, Bolivia, and Ecuador, followed by Eastern Asian Countries such as Japan and South Korea. Lower incidence of the disease is reported in Europe, and the North American continent is considered a low risk area. No clear factors are associated with the development of gallbladder cancer; yet some risk factors are frequently linked to it. In the next sections, possible risk factors are discussed followed by clinical presentation, investigations, and treatment considerations for patients with gallbladder cancer.

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References

  1. Blalock AA. A statistical study of 888 cases of biliary tract disease. Johns Hopkins Hosp Bull. 1924;35:391–409.

    Google Scholar 

  2. Tada M, Yokosuka O, Omata M, Ohto M, Isono K. Analysis of ras gene mutations in biliary and pancreatic tumors by polymerase chain reaction and direct sequencing. Cancer. 1990;66(5):930–5.

    Article  CAS  PubMed  Google Scholar 

  3. Lazcano-Ponce EC, Miquel JF, Muñoz N, Herrero R, Ferrecio C, Wistuba II, et al. Epidemiology and molecular pathology of gallbladder cancer. CA Cancer J Clin. 2001;51(6):349–64.

    Article  CAS  PubMed  Google Scholar 

  4. Randi G, Franceschi S, La Vecchia C. Gallbladder cancer worldwide: geographical distribution and risk factors. Int J Cancer. 2006;118(7):1591–602.

    Article  CAS  PubMed  Google Scholar 

  5. Carriaga MT, Henson DE. Liver, gallbladder, extrahepatic bile ducts, and pancreas. Cancer. 1995;75(1 Suppl):171–90.

    Article  CAS  PubMed  Google Scholar 

  6. Barakat J, Dunkelberg JC, Ma TY. Changing patterns of gallbladder carcinoma in New Mexico. Cancer. 2006;106(2):434–40.

    Article  PubMed  Google Scholar 

  7. Henson DE, Albores-Saavedra J, Corle D. Carcinoma of the gallbladder. Histologic types, stage of disease, grade, and survival rates. Cancer. 1992;70(6):1493–7.

    Article  CAS  PubMed  Google Scholar 

  8. Perpetuo MD, Valdivieso M, Heilbrun LK, Nelson RS, Connor T, Bodey GP. Natural history study of Gallbladder cancer (GBC): a review of 36 years experience at M. D. Anderson Hospital and Tumor Institute. Cancer. 1978;42(1):330–5.

    Article  CAS  PubMed  Google Scholar 

  9. Graham EA. The prevention of carcinoma of the gall-bladder. Ann Surg. 1931;93(1):317–22.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Hart J, Modan B, Shani M. Cholelithiasis in the aetiology of gallbladder neoplasms. Lancet. 1971;1(7710):1151–3.

    Article  CAS  PubMed  Google Scholar 

  11. Hsing AW, Gao YT, Han TQ, Rashid A, Sakoda LC, Wang BS, et al. Gallstones and the risk of biliary tract cancer: a population-based study in China. Br J Cancer. 2007;97(11):1577–82.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Albores-Saavedra J, Alcántra-Vazquez A, Cruz-Ortiz H, Herrera-Goepfert R. The precursor lesions of invasive gallbladder carcinoma. Hyperplasia, atypical hyperplasia and carcinoma in situ. Cancer. 1980;45(5):919–27.

    Article  CAS  PubMed  Google Scholar 

  13. Chow WH, Johansen C, Gridley G, Mellemkjaer L, Olsen JH, Fraumeni JF. Gallstones, cholecystectomy and risk of cancers of the liver, biliary tract and pancreas. Br J Cancer. 1999;79(3–4):640–4.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Diehl AK. Gallstone size and the risk of gallbladder cancer. JAMA. 1983;250(17):2323–6.

    Article  CAS  PubMed  Google Scholar 

  15. Lowenfels AB, Walker AM, Althaus DP, Townsend G, Domellöf L. Gallstone growth, size, and risk of Gallbladder cancer (GBC): an interracial study. Int J Epidemiol. 1989;18(1):50–4.

    Article  CAS  PubMed  Google Scholar 

  16. Strom BL, Soloway RD, Rios-Dalenz JL, Rodriguez-Martinez HA, West SL, Kinman JL, et al. Risk factors for gallbladder cancer. An international collaborative case-control study. Cancer. 1995;76(10):1747–56.

    Article  CAS  PubMed  Google Scholar 

  17. Wenckert A, Robertson B. The natural course of gallstone disease: eleven-year review of 781 nonoperated cases. Gastroenterology. 1966;50(3):376–81.

    CAS  PubMed  Google Scholar 

  18. Berk RN, Armbuster TG, Saltzstein SL. Carcinoma in the porcelain gallbladder. Radiology. 1973;106(1):29–31.

    Article  CAS  PubMed  Google Scholar 

  19. Ashur H, Siegal B, Oland Y, Adam YG. Calcified ballbladder (porcelain gallbladder). Arch Surg. 1978;113(5):594–6.

    Article  CAS  PubMed  Google Scholar 

  20. Pandey M, Shukla VK. Lifestyle, parity, menstrual and reproductive factors and risk of gallbladder cancer. Eur J Cancer Prev. 2003;12(4):269–72.

    Article  CAS  PubMed  Google Scholar 

  21. Stephen AE, Berger DL. Carcinoma in the porcelain gallbladder: a relationship revisited. Surgery. 2001;129(6):699–703.

    Article  CAS  PubMed  Google Scholar 

  22. Khan ZS, Livingston EH, Huerta S. Reassessing the need for prophylactic surgery in patients with porcelain gallbladder: case series and systematic review of the literature. Arch Surg. 2011;146(10):1143–7.

    Article  PubMed  Google Scholar 

  23. Cunningham SC, Alexander HR. Porcelain gallbladder and cancer: ethnicity explains a discrepant literature? Am J Med. 2007;120(4):e17–8.

    Article  PubMed  Google Scholar 

  24. Brown KM, Geller DA. Porcelain gallbladder and risk of gallbladder cancer. Arch Surg. 2011;146(10):1148.

    Article  PubMed  Google Scholar 

  25. Kwon AH, Inui H, Matsui Y, Uchida Y, Hukui J, Kamiyama Y. Laparoscopic cholecystectomy in patients with porcelain gallbladder based on the preoperative ultrasound findings. Hepatogastroenterology. 2004;51(58):950–3.

    PubMed  Google Scholar 

  26. Terzi C, Sökmen S, Seçkin S, Albayrak L, Uğurlu M. Polypoid lesions of the gallbladder: report of 100 cases with special reference to operative indications. Surgery. 2000;127(6):622–7.

    Article  CAS  PubMed  Google Scholar 

  27. Ishikawa O, Ohhigashi H, Imaoka S, Nakaizumi A, Kitamura T, Sasaki Y, et al. The difference in malignancy between pedunculated and sessile polypoid lesions of the gallbladder. Am J Gastroenterol. 1989;84(11):1386–90.

    CAS  PubMed  Google Scholar 

  28. Pilgrim CHC, Groeschl RT, Christians KK, Gamblin TC. Modern perspectives on factors predisposing to the development of gallbladder cancer. HPB. 2013;15(11):839–44.

    Article  PubMed  PubMed Central  Google Scholar 

  29. Sugiyama M, Xie XY, Atomi Y, Saito M. Differential diagnosis of small polypoid lesions of the gallbladder: the value of endoscopic ultrasonography. Ann Surg. 1999;229(4):498–504.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  30. Furukawa H, Kosuge T, Shimada K, Yamamoto J, Kanai Y, Mukai K, et al. Small polypoid lesions of the gallbladder: differential diagnosis and surgical indications by helical computed tomography. Arch Surg. 1998;133(7):735–9.

    Article  CAS  PubMed  Google Scholar 

  31. Cheon YK, Cho WY, Lee TH, Cho YD, Moon JH, Lee JS, et al. Endoscopic ultrasonography does not differentiate neoplastic from non-neoplastic small gallbladder polyps. World J Gastroenterol. 2009;15(19):2361–6.

    Article  PubMed  PubMed Central  Google Scholar 

  32. Ito H, Hann LE, D'Angelica M, Allen P, Fong Y, Dematteo RP, et al. Polypoid lesions of the gallbladder: diagnosis and followup. J Am Coll Surg. 2009;208(4):570–5.

    Article  PubMed  Google Scholar 

  33. Yang HL, Sun YG, Wang Z. Polypoid lesions of the gallbladder: diagnosis and indications for surgery. Br J Surg. 1992;79(3):227–9.

    Article  CAS  PubMed  Google Scholar 

  34. Kubota K, Bandai Y, Noie T, Ishizaki Y, Teruya M, Makuuchi M. How should polypoid lesions of the gallbladder be treated in the era of laparoscopic cholecystectomy? Surgery. 1995;117(5):481–7.

    Article  CAS  PubMed  Google Scholar 

  35. Anderson MA, Appalaneni V, Ben-Menachem T, Decker GA, Early DS, Evans JA, et al. The role of endoscopy in the evaluation and treatment of patients with biliary neoplasia. Gastrointest Endosc. 2013;77(2):167–74.

    Article  PubMed  Google Scholar 

  36. Sarkut P, Kilicturgay S, Ozer A, Ozturk E, Yilmazlar T. Gallbladder polyps: factors affecting surgical decision. World J Gastroenterol. 2013;19(28):4526–30.

    Article  PubMed  PubMed Central  Google Scholar 

  37. Hu B, Gong B, Zhou DY. Association of anomalous pancreaticobiliary ductal junction with gallbladder carcinoma in Chinese patients: an ERCP study. Gastrointest Endosc. 2003;57(4):541–5.

    Article  PubMed  Google Scholar 

  38. Chijiiwa K, Kimura H, Tanaka M. Malignant potential of the gallbladder in patients with anomalous pancreaticobiliary ductal junction. The difference in risk between patients with and without choledochal cyst. Int Surg. 1995;80(1):61–4.

    CAS  PubMed  Google Scholar 

  39. Roukounakis NE, Kuhn JA, McCarty TM. Association of an abnormal pancreaticobiliary junction with biliary tract cancers. Proc (Bayl Univ Med Cent). 2000;13(1):11–3.

    CAS  Google Scholar 

  40. Hasumi A, Matsui H, Sugioka A, Uyama I, Komori Y, Fujita J, et al. Precancerous conditions of biliary tract cancer in patients with pancreaticobiliary maljunction: reappraisal of nationwide survey in Japan. J Hepatobiliary Pancreat Surg. 2000;7(6):551–5.

    Article  CAS  PubMed  Google Scholar 

  41. Kang CM, Kim KS, Choi JS, Lee WJ, Kim BR. Gallbladder carcinoma associated with anomalous pancreaticobiliary duct junction. Can J Gastroenterol. 2007;21(6):383–7.

    Article  PubMed  PubMed Central  Google Scholar 

  42. Elnemr A, Ohta T, Kayahara M, Kitagawa H, Yoshimoto K, Tani T, et al. Anomalous pancreaticobiliary ductal junction without bile duct dilatation in gallbladder cancer. Hepatogastroenterology. 2001;48(38):382–6.

    CAS  PubMed  Google Scholar 

  43. Jain K, Sreenivas V, Velpandian T, Kapil U, Garg PK. Risk factors for Gallbladder cancer (GBC): a case-control study. Int J Cancer. 2013;132(7):1660–6.

    Article  CAS  PubMed  Google Scholar 

  44. Yagyu K, Kikuchi S, Obata Y, Lin Y, Ishibashi T, Kurosawa M, et al. Cigarette smoking, alcohol drinking and the risk of gallbladder cancer death: a prospective cohort study in Japan. Int J Cancer. 2008;122(4):924–9.

    Article  CAS  PubMed  Google Scholar 

  45. Scott TE, Carroll M, Cogliano FD, Smith BF, Lamorte WW. A case-control assessment of risk factors for gallbladder carcinoma. Dig Dis Sci. 1999;44(8):1619–25.

    Article  CAS  PubMed  Google Scholar 

  46. Dutta U, Garg PK, Kumar R, Tandon RK. Typhoid carriers among patients with gallstones are at increased risk for carcinoma of the gallbladder. Am J Gastroenterol. 2000;95(3):784–7.

    Article  CAS  PubMed  Google Scholar 

  47. Shukla VK, Singh H, Pandey M, Upadhyay SK, Nath G. Carcinoma of the gallbladder—is it a sequel of typhoid? Dig Dis Sci. 2000;45(5):900–3.

    Article  CAS  PubMed  Google Scholar 

  48. Nagaraja V, Eslick GD. Systematic review with meta-analysis: the relationship between chronic Salmonella typhi carrier status and gall-bladder cancer. Aliment Pharmacol Ther. 2014;39(8):745–50.

    Article  CAS  PubMed  Google Scholar 

  49. Nath G, Singh H, Shukla VK. Chronic typhoid carriage and carcinoma of the gallbladder. Eur J Cancer Prev. 1997;6(6):557–9.

    Article  CAS  PubMed  Google Scholar 

  50. Ellis EF, Gordon PR, Gottlieb LS. Oral contraceptives and cholangiocarcinoma. Lancet. 1978;1(8057):207.

    Article  CAS  PubMed  Google Scholar 

  51. Lowenfels AB, Norman J. Isoniazid and bile duct cancer. JAMA. 1978;240(5):434–5.

    Article  CAS  PubMed  Google Scholar 

  52. Brodén G, Bengtsson L. Biliary carcinoma associated with methyldopa therapy. Acta Chir Scand Suppl. 1980;500:7–12.

    PubMed  Google Scholar 

  53. Duffy A, Capanu M, Abou-Alfa GK, Huitzil D, Jarnagin W, Fong Y, et al. Gallbladder cancer (GBC): 10-year experience at Memorial Sloan-Kettering Cancer Centre (MSKCC). J Surg Oncol. 2008;98(7):485–9.

    Article  CAS  PubMed  Google Scholar 

  54. Darmas B, Mahmud S, Abbas A, Baker AL. Is there any justification for the routine histological examination of straightforward cholecystectomy specimens? Ann R Coll Surg Engl. 2007;89(3):238–41.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  55. Frauenschuh D, Greim R, Kraas E. How to proceed in patients with carcinoma detected after laparoscopic cholecystectomy. Langenbecks Arch Surg. 2000;385(8):495–500.

    Article  CAS  PubMed  Google Scholar 

  56. Miller G, Jarnagin WR. Gallbladder carcinoma. Eur J Surg Oncol. 2008;34(3):306–12.

    Article  CAS  PubMed  Google Scholar 

  57. Matthyssens LE, Ziol M, Barrat C, Champault GG. Routine surgical pathology in general surgery. Br J Surg. 2006;93(3):362–8.

    Article  CAS  PubMed  Google Scholar 

  58. Misra S, Chaturvedi A, Misra NC, Sharma ID. Carcinoma of the gallbladder. Lancet Oncol. 2003;4(3):167–76.

    Article  PubMed  Google Scholar 

  59. Hawkins WG, DeMatteo RP, Jarnagin WR, Ben-Porat L, Blumgart LH, Fong Y. Jaundice predicts advanced disease and early mortality in patients with gallbladder cancer. Ann Surg Oncol. 2004;11(3):310–5.

    Article  PubMed  Google Scholar 

  60. Malik IA. Clinicopathological features and management of gallbladder cancer in Pakistan: a prospective study of 233 cases. J Gastroenterol Hepatol. 2003;18(8):950–3.

    Article  PubMed  Google Scholar 

  61. Thorbjarnarson B, Glenn F. Carcinoma of the gallbladder. Cancer. 1959;12:1009–15.

    Article  CAS  PubMed  Google Scholar 

  62. Joo I, Lee JY, Kim JH, Kim SJ, Kim MA, Han JK, et al. Differentiation of adenomyomatosis of the gallbladder from early-stage, wall-thickening-type gallbladder cancer using high-resolution ultrasound. Eur Radiol. 2013;23(3):730–8.

    Article  PubMed  Google Scholar 

  63. Komatsuda T, Ishida H, Konno K, Hamashima Y, Naganuma H, Sato M, et al. Gallbladder carcinoma: color Doppler sonography. Abdom Imaging. 2000;25(2):194–7.

    Article  CAS  PubMed  Google Scholar 

  64. Ueno N, Tomiyama T, Tano S, Wada S, Kimura K. Diagnosis of gallbladder carcinoma with color Doppler ultrasonography. Am J Gastroenterol. 1996;91(8):1647–9.

    CAS  PubMed  Google Scholar 

  65. Chijiiwa K, Sumiyoshi K, Nakayama F. Impact of recent advances in hepatobiliary imaging techniques on the preoperative diagnosis of carcinoma of the gallbladder. World J Surg. 1991;15(3):322–7.

    Article  CAS  PubMed  Google Scholar 

  66. Jang JY, Kim SW, Lee SE, Hwang DW, Kim EJ, Lee JY, et al. Differential diagnostic and staging accuracies of high resolution ultrasonography, endoscopic ultrasonography, and multidetector computed tomography for gallbladder polypoid lesions and gallbladder cancer. Ann Surg. 2009;250(6):943–9.

    Article  PubMed  Google Scholar 

  67. Pandey M, Sood BP, Shukla RC, Aryya NC, Singh S, Shukla VK. Carcinoma of the gallbladder: role of sonography in diagnosis and staging. J Clin Ultrasound. 2000;28(5):227–32.

    Article  CAS  PubMed  Google Scholar 

  68. Bach AM, Loring LA, Hann LE, Illescas FF, Fong Y, Blumgart LH. Gallbladder cancer (GBC): can ultrasonography evaluate extent of disease? J Ultrasound Med. 1998;17(5):303–9.

    CAS  PubMed  Google Scholar 

  69. Kim HJ, Park JH, Park DI, Cho YK, Sohn CI, Jeon WK, et al. Clinical usefulness of endoscopic ultrasonography in the differential diagnosis of gallbladder wall thickening. Dig Dis Sci. 2012;57(2):508–15.

    Article  PubMed  Google Scholar 

  70. Mizuguchi M, Kudo S, Fukahori T, Matsuo Y, Miyazaki K, Tokunaga O, et al. Endoscopic ultrasonography for demonstrating loss of multiple-layer pattern of the thickened gallbladder wall in the preoperative diagnosis of gallbladder cancer. Eur Radiol. 1997;7(8):1323–7.

    Article  CAS  PubMed  Google Scholar 

  71. Sadamoto Y, Kubo H, Harada N, Tanaka M, Eguchi T, Nawata H. Preoperative diagnosis and staging of gallbladder carcinoma by EUS. Gastrointest Endosc. 2003;58(4):536–41.

    Article  PubMed  Google Scholar 

  72. Fujita N, Noda Y, Kobayashi G, Kimura K, Yago A. Diagnosis of the depth of invasion of gallbladder carcinoma by EUS. Gastrointest Endosc. 1999;50(5):659–63.

    Article  CAS  PubMed  Google Scholar 

  73. Kalra N, Suri S, Gupta R, Natarajan SK, Khandelwal N, Wig JD, et al. MDCT in the staging of gallbladder carcinoma. Am J Roentgenol. 2006;186(3):758–62.

    Article  Google Scholar 

  74. Kim SJ, Lee JM, Lee JY, Kim SH, Han JK, Choi BI, et al. Analysis of enhancement pattern of flat gallbladder wall thickening on MDCT to differentiate gallbladder cancer from cholecystitis. Am J Roentgenol. 2008;191(3):765–71.

    Article  Google Scholar 

  75. Pilgrim CHC, Groeschl RT, Pappas SG, Gamblin TC. An often overlooked diagnosis: imaging features of gallbladder cancer. J Am Coll Surg. 2013;216(2):333–9.

    Article  PubMed  Google Scholar 

  76. Kim BS, Ha HK, Lee IJ, Kim JH, Eun HW, Bae IY, et al. Accuracy of CT in local staging of gallbladder carcinoma. Acta Radiol. 2002;43(1):71–6.

    Article  CAS  PubMed  Google Scholar 

  77. Kim SJ, Lee JM, Lee JY, Choi JY, Kim SH, Han JK, et al. Accuracy of preoperative T-staging of gallbladder carcinoma using MDCT. Am J Roentgenol. 2008;190(1):74–80.

    Article  Google Scholar 

  78. Schwartz LH, Black J, Fong Y, Jarnagin W, Blumgart L, Gruen D, et al. Gallbladder carcinoma: findings at MR imaging with MR cholangiopancreatography. J Comput Assist Tomogr. 2002;26(3):405–10.

    Article  PubMed  Google Scholar 

  79. Kim JH, Kim TK, Eun HW, Kim BS, Lee MG, Kim PN, et al. Preoperative evaluation of gallbladder carcinoma: efficacy of combined use of MR imaging, MR cholangiography, and contrast-enhanced dual-phase three-dimensional MR angiography. J Magn Reson Imaging. 2002;16(6):676–84.

    Article  PubMed  Google Scholar 

  80. Delbeke D, Martin WH, Sandler MP, Chapman WC, Wright JK, Pinson CW. Evaluation of benign vs malignant hepatic lesions with positron emission tomography. Arch Surg. 1998;133(5):510–5. discussion 5–6.

    Article  CAS  PubMed  Google Scholar 

  81. Corvera CU, Blumgart LH, Akhurst T, DeMatteo RP, D'Angelica M, Fong Y, et al. 18F-fluorodeoxyglucose positron emission tomography influences management decisions in patients with biliary cancer. J Am Coll Surg. 2008;206(1):57–65.

    Article  PubMed  Google Scholar 

  82. Rodriguez-Fernandez A, Gomez-Rio M, Llamas-Elvira JM, Ortega-Lozano S, Ferron-Orihuela JA, Ramia-Angel JM, et al. Positron-emission tomography with fluorine-18-fluoro-2-deoxy-D-glucose for gallbladder cancer diagnosis. Am J Surg. 2004;188(2):171–5.

    Article  PubMed  Google Scholar 

  83. Oe A, Kawabe J, Torii K, Kawamura E, Higashiyama S, Kotani J, et al. Distinguishing benign from malignant gallbladder wall thickening using FDG-PET. Ann Nucl Med. 2006;20(10):699–703.

    Article  PubMed  Google Scholar 

  84. Hansen N, Brown RK, Khan A, Frey KA, Orringer M. False positive diagnosis of metastatic esophageal carcinoma on positron emission tomography: a case report of cholecystitis simulating a hepatic lesion. Clin Nucl Med. 2010;35(6):409–12.

    Article  PubMed  Google Scholar 

  85. Strom BL, Maislin G, West SL, Atkinson B, Herlyn M, Saul S, et al. Serum CEA and CA 19-9: potential future diagnostic or screening tests for gallbladder cancer? Int J Cancer. 1990;45(5):821–4.

    Article  CAS  PubMed  Google Scholar 

  86. Ritts RE, Nagorney DM, Jacobsen DJ, Talbot RW, Zurawski VR. Comparison of preoperative serum CA19-9 levels with results of diagnostic imaging modalities in patients undergoing laparotomy for suspected pancreatic or gallbladder disease. Pancreas. 1994;9(6):707–16.

    Article  PubMed  Google Scholar 

  87. Ching BH, Yeh BM, Westphalen AC, Joe BN, Qayyum A, Coakley FV. CT differentiation of adenomyomatosis and gallbladder cancer. Am J Roentgenol. 2007;189(1):62–6.

    Article  Google Scholar 

  88. Onoyama H, Yamamoto M, Tseng A, Ajiki T, Saitoh Y. Extended cholecystectomy for carcinoma of the gallbladder. World J Surg. 1995;19(5):758–63.

    Article  CAS  PubMed  Google Scholar 

  89. Nevin JE, Moran TJ, Kay S, King R. Carcinoma of the gallbladder: staging, treatment, and prognosis. Cancer. 1976;37(1):141–8.

    Article  CAS  PubMed  Google Scholar 

  90. Donohue JH, Nagorney DM, Grant CS, Tsushima K, Ilstrup DM, Adson MA. Carcinoma of the gallbladder. Does radical resection improve outcome? Arch Surg. 1990;125(2):237–41.

    Article  CAS  PubMed  Google Scholar 

  91. Fong Y, Wagman L, Gonen M, Crawford J, Reed W, Swanson R, et al. Evidence-based gallbladder cancer staging: changing cancer staging by analysis of data from the National Cancer Database. Ann Surg. 2006;243(6):767–71. discussion 71–4.

    Article  PubMed  PubMed Central  Google Scholar 

  92. Cho JY, Han HS, Yoon YS, Ahn KS, Kim YH, Lee KH. Laparoscopic approach for suspected early-stage gallbladder carcinoma. Arch Surg. 2010;145(2):128–33.

    Article  PubMed  Google Scholar 

  93. Sarli L, Pietra N, Costi R, Grattarola M. Gallbladder perforation during laparoscopic cholecystectomy. World J Surg. 1999;23(11):1186–90.

    Article  CAS  PubMed  Google Scholar 

  94. Weiland ST, Mahvi DM, Niederhuber JE, Heisey DM, Chicks DS, Rikkers LF. Should suspected early gallbladder cancer be treated laparoscopically? J Gastrointest Surg. 2002;6(1):50–6. discussion 6–7.

    Article  PubMed  Google Scholar 

  95. Agarwal AK, Kalayarasan R, Javed A, Gupta N, Nag HH. The role of staging laparoscopy in primary gall bladder cancer—an analysis of 409 patients: a prospective study to evaluate the role of staging laparoscopy in the management of gallbladder cancer. Ann Surg. 2013;258(2):318–23.

    Article  PubMed  Google Scholar 

  96. Weber SM, DeMatteo RP, Fong Y, Blumgart LH, Jarnagin WR. Staging laparoscopy in patients with extrahepatic biliary carcinoma. Analysis of 100 patients. Ann Surg. 2002;235(3):392–9.

    Article  PubMed  PubMed Central  Google Scholar 

  97. Yamaguchi K, Chijiiwa K, Ichimiya H, Sada M, Kawakami K, Nishikata F, et al. Gallbladder carcinoma in the era of laparoscopic cholecystectomy. Arch Surg. 1996;131(9):981–4. discussion 5.

    Article  CAS  PubMed  Google Scholar 

  98. Ootani T, Shirai Y, Tsukada K, Muto T. Relationship between gallbladder carcinoma and the segmental type of adenomyomatosis of the gallbladder. Cancer. 1992;69(11):2647–52.

    Article  CAS  PubMed  Google Scholar 

  99. Abramson MA, Pandharipande P, Ruan D, Gold JS, Whang EE. Radical resection for T1b Gallbladder cancer (GBC): a decision analysis. HPB (Oxford). 2009;11(8):656–63.

    Article  Google Scholar 

  100. Wakai T, Shirai Y, Sakata J, Nagahashi M, Ajioka Y, Hatakeyama K. Mode of hepatic spread from gallbladder carcinoma: an immunohistochemical analysis of 42 hepatectomized specimens. Am J Surg Pathol. 2010;34(1):65–74.

    Article  PubMed  Google Scholar 

  101. D'Angelica M, Dalal KM, DeMatteo RP, Fong Y, Blumgart LH, Jarnagin WR. Analysis of the extent of resection for adenocarcinoma of the gallbladder. Ann Surg Oncol. 2009;16(4):806–16.

    Article  PubMed  Google Scholar 

  102. Pawlik TM, Gleisner AL, Vigano L, Kooby DA, Bauer TW, Frilling A, et al. Incidence of finding residual disease for incidental gallbladder carcinoma: implications for re-resection. J Gastrointest Surg. 2007;11(11):1478–86. discussion 86–7.

    Article  PubMed  Google Scholar 

  103. Ito H, Ito K, D'Angelica M, Gonen M, Klimstra D, Allen P, et al. Accurate staging for Gallbladder cancer (GBC): implications for surgical therapy and pathological assessment. Ann Surg. 2011;254(2):320–5.

    Article  PubMed  Google Scholar 

  104. Downing SR, Cadogan KA, Ortega G, Oyetunji TA, Siram SM, Chang DC, et al. Early-stage gallbladder cancer in the surveillance, epidemiology, and end results database: effect of extended surgical resection. Arch Surg. 2011;146(6):734–8.

    Article  PubMed  Google Scholar 

  105. Shih SP, Schulick RD, Cameron JL, Lillemoe KD, Pitt HA, Choti MA, et al. Gallbladder cancer (GBC): the role of laparoscopy and radical resection. Ann Surg. 2007;245(6):893–901.

    Article  PubMed  PubMed Central  Google Scholar 

  106. Kapoor VK, Pradeep R, Haribhakti SP, Singh V, Sikora SS, Saxena R, et al. Intrahepatic segment III cholangiojejunostomy in advanced carcinoma of the gallbladder. Br J Surg. 1996;83(12):1709–11.

    Article  CAS  PubMed  Google Scholar 

  107. Saluja SS, Gulati M, Garg PK, Pal H, Pal S, Sahni P, et al. Endoscopic or percutaneous biliary drainage for Gallbladder cancer (GBC): a randomized trial and quality of life assessment. Clin Gastroenterol Hepatol. 2008;6(8):944–50.e3.

    Article  PubMed  Google Scholar 

  108. Robson PC, Heffernan N, Gonen M, Thornton R, Brody LA, Holmes R, et al. Prospective study of outcomes after percutaneous biliary drainage for malignant biliary obstruction. Ann Surg Oncol. 2010;17(9):2303–11.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  109. Iyer RV, Gibbs J, Kuvshinoff B, Fakih M, Kepner J, Soehnlein N, et al. A phase II study of gemcitabine and capecitabine in advanced cholangiocarcinoma and carcinoma of the gallbladder: a single-institution prospective study. Ann Surg Oncol. 2007;14(11):3202–9.

    Article  PubMed  Google Scholar 

  110. Riechelmann RP, Townsley CA, Chin SN, Pond GR, Knox JJ. Expanded phase II trial of gemcitabine and capecitabine for advanced biliary cancer. Cancer. 2007;110(6):1307–12.

    Article  CAS  PubMed  Google Scholar 

  111. Verderame F, Russo A, Di Leo R, Badalamenti G, Santangelo D, Cicero G, et al. Gemcitabine and oxaliplatin combination chemotherapy in advanced biliary tract cancers. Ann Oncol. 2006;17 Suppl 7:vii68–72.

    PubMed  Google Scholar 

  112. Valle J, Wasan H, Palmer DH, Cunningham D, Anthoney A, Maraveyas A, et al. Cisplatin plus gemcitabine versus gemcitabine for biliary tract cancer. N Engl J Med. 2010;362(14):1273–81.

    Article  CAS  PubMed  Google Scholar 

  113. Houry S, Barrier A, Huguier M. Irradiation therapy for gallbladder carcinoma: recent advances. J Hepatobiliary Pancreat Surg. 2001;8(6):518–24.

    Article  CAS  PubMed  Google Scholar 

  114. Wang SJ, Fuller CD, Kim JS, Sittig DF, Thomas CR, Ravdin PM. Prediction model for estimating the survival benefit of adjuvant radiotherapy for gallbladder cancer. J Clin Oncol. 2008;26(13):2112–7.

    Article  PubMed  Google Scholar 

  115. Lin LL, Picus J, Drebin JA, Linehan DC, Solis J, Strasberg SM, et al. A phase II study of alternating cycles of split course radiation therapy and gemcitabine chemotherapy for inoperable pancreatic or biliary tract carcinoma. Am J Clin Oncol. 2005;28(3):234–41.

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Division of Surgical Oncology, Medical College of Wisconsin, 9200 West Wisconsin Avenue, Milwaukee, WI, 53226-3596, USA

    Abdulrahman Y. Hammad M.D., Natesh Shivakumar & T. Clark Gamblin M.D., M.S.

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  1. Abdulrahman Y. Hammad M.D.
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  2. Natesh Shivakumar
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  3. T. Clark Gamblin M.D., M.S.
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Correspondence to T. Clark Gamblin M.D., M.S. .

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  1. Division of Gastroenterology & Hepatology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA

    Kulwinder Dua

  2. Division of Gastroenterology & Hepatology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA

    Reza Shaker

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Hammad, A.Y., Shivakumar, N., Gamblin, T.C. (2016). Point-of-Care Clinical Guide: Gallbladder Cancer. In: Dua, K., Shaker, R. (eds) Pancreas and Biliary Disease. Springer, Cham. https://doi.org/10.1007/978-3-319-28089-9_15

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  • DOI: https://doi.org/10.1007/978-3-319-28089-9_15

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