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The Role of Microenvironment in the Control of Tumor Angiogenesis pp 11–18Cite as

Tumor Blood Vessels and Tumor Endothelial Cells

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Abstract

Tumor endothelial cells contribute to tumor progression through recruitment of endothelial precursor cells and changes in the structure of the existing vascular endothelium creating an escape route for cancer cells to generate metastases. The tumor-associated endothelium is structurally defective, express several cell surface markers absent in quiescent blood vessels, and present several gene expression abnormalities. Pericytes deficiency could be responsible for vessel abnormalities in tumor blood vessels and partial dissociation of pericytes contribute to increased tumor vascular permeability.

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Authors and Affiliations

  1. Department of Basic Medical Sciences, Neurosciences and Sensory Organs, University of Bari Medical School, Bari, Italy

    Domenico Ribatti

  2. National Cancer Institute “Giovanni Paolo II”, Bari, Italy

    Domenico Ribatti

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  1. Domenico Ribatti
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Ribatti, D. (2016). Tumor Blood Vessels and Tumor Endothelial Cells. In: The Role of Microenvironment in the Control of Tumor Angiogenesis. Springer, Cham. https://doi.org/10.1007/978-3-319-27820-9_2

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