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Biochemistry and Molecular Biology pp 361–385Cite as

15 Genetic and Metabolic Aspects of Primary and Secondary Metabolism of the Zygomycetes

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Part of the book series: The Mycota ((MYCOTA,volume III))

Abstract

Basal lineages of the kingdom of fungi comprise terrestrial and aquatic fungi, which are traditionally summarized as Chytridiomycota and Zygomycota in a colloquial sense. The zygomycetes build up the most basal lineage among the terrestrial fungi. As the earliest fungi to conquer terrestrial habitats, they facilitated early coevolution with other land-dwelling microorganisms with implications on the primary and secondary metabolism which is adaptive to the life in soil. Advances in next-generation genome sequencing allow us to gain a new layer of knowledge with respect to their metabolism and its regulation. Recent revisions of the metabolic potential of zygomycetes using genome mining suggested a hidden potential for the production of secondary metabolites. First insights suggest a revision of our understanding of the importance and mode of action of metabolic pathways revealing a fascinating potential to produce novel natural compounds. The aim of this review is to draw attention to the zygomycetes as a unique fungal group and to inspire the scientific community to explore its potential as participants in complex ecosystems for innovative metabolic regulatory frameworks and novel compounds.

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Authors and Affiliations

  1. Jena Microbial Resource Collection, Leibniz Institute for Natural Product Research and Infection Biology – Hans-Knöll-Institute, Adolf-Reichwein-Strasse 23, 07745, Jena, Germany

    Kerstin Voigt

  2. Department of Microbiology and Molecular Biology, Institute of Microbiology, University of Jena, Neugasse 25, 07743, Jena, Germany

    Kerstin Voigt

  3. Systems Biology/Bioinformatics, Leibniz Institute for Natural Product Research and Infection Biology – Hans-Knöll-Institute, Adolf-Reichwein-Strasse 23, 07745, Jena, Germany

    Thomas Wolf & Ekaterina Shelest

  4. Karlsruhe Institute of Technology (KIT), Institute of Process Engineering in Life Sciences, Section II: Technical Biology, Engler-Bunte-Ring 1, 76131, Karlsruhe, Germany

    Katrin Ochsenreiter

  5. Faculty of Science and Informatics, Department of Microbiology, University of Szeged, Közép fasor 52, 6726, Szeged, Hungary

    Gábor Nagy & Tamás Papp

  6. National Reference Center for Invasive Mycoses, Leibniz Institute for Natural Product Research and Infection Biology – Hans-Knöll-Institute, Adolf-Reichwein-Strasse 23, 07745, Jena, Germany

    Kerstin Kaerger

Authors
  1. Kerstin Voigt
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  2. Thomas Wolf
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  3. Katrin Ochsenreiter
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  4. Gábor Nagy
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  5. Kerstin Kaerger
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  6. Ekaterina Shelest
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  7. Tamás Papp
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Corresponding author

Correspondence to Kerstin Voigt .

Editor information

Editors and Affiliations

  1. Pharmazeutische Mikrobiologie, Friedrich-Schiller-Universität, Jena, Germany

    Dirk Hoffmeister

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Voigt, K. et al. (2016). 15 Genetic and Metabolic Aspects of Primary and Secondary Metabolism of the Zygomycetes. In: Hoffmeister, D. (eds) Biochemistry and Molecular Biology. The Mycota, vol III. Springer, Cham. https://doi.org/10.1007/978-3-319-27790-5_15

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