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Role of Lipoxygenases in Pathogenesis of Cancer

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Lipoxygenases in Inflammation

Part of the book series: Progress in Inflammation Research ((PIR))

Abstract

Increasing evidence in literature implicates lipoxygenases as players in the growth of several solid tumor types, including pancreatic, colorectal, prostate and breast cancer. Recently, a role of 5-lipoxygenase was reported in hemato-oncological tumors, such as chronic myeloid leukemia and acute myeloid leukemia. Whereas 5-lipoxygenase and 12-lipoxygenase are generally recognized as pro-carcinogenic, the related enzyme 15-lipoxygenase-2 is down-regulated in malignant tissues, considered to function as a tumor suppressor and to inhibit tumour growth. The role of 15-lipoxygenase-1 is still subject of controversy in the literature.

The following comprehensive review summarizes experimental findings arguing for a role of lipoxygenases in several most-concerned tumor types, including pancreatic cancer, breast cancer, prostate cancer, colorectal cancer and leukemia. Furthermore, we describe own experimental evidence raising question on the use of cytotoxic effects by lipoxygenase inhibitors or mitogenic effects by lipoxygenase-derived mediators in cell culture assays as argument for a tumorigenic role of lipoxygenases and their products in cancer.

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Acknowledgement

This work was supported by the German Research Foundation (DFG-MA-5825/1-1 and Sonderforschungsbereich SFB 1039) and the Else Kröner-Fresenius-Stiftung (stipend of the graduate school “Translational Research Innovation–Pharma”). T.J. Maier is recipient of a Heisenberg fellowship of the German Research Foundation (DFG-MA-5825/2-1).

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  1. Institute of Pharmaceutical Chemistry/ZAFES, Goethe-University, Max-von-Laue-Str. 9, 60438, Frankfurt/Main, Germany

    J. Roos, B. Kühn, J. Fettel, I. V. Maucher, A. Kahnt & D. Steinhilber

  2. Department of Hematology, Goethe University, 60590, Frankfurt, Germany

    M. Ruthardt

  3. Department of Biomedicine, Aarhus University, Bartholins Allé 6, 8000, Aarhus C, Denmark

    T. Vorup-Jensen, C. Matrone & T. J. Maier

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    Dieter Steinhilber

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Roos, J. et al. (2016). Role of Lipoxygenases in Pathogenesis of Cancer. In: Steinhilber, D. (eds) Lipoxygenases in Inflammation. Progress in Inflammation Research. Springer, Cham. https://doi.org/10.1007/978-3-319-27766-0_7

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