Abstract
The micro-neuroanatomy of the vagus nerve (VN), superior laryngeal nerve (SLN), recurrent laryngeal nerve (RLN), and their respective central connections are complex. While there has been some clarity amongst animal and human studies, there is considerable debate regarding central contributions and topography, as well as peripheral fiber types, topographical organization, and function. This chapter will discuss the micro-neuroanatomy of the central connections, neural ganglia, and each nerve separately. Meanwhile, because the micro-neuroanatomy provides information regarding the form underlying the function of the larynx, further consideration of laryngeal dysfunction is addressed through additional sections covering age-related changes, neural injury, and neural regeneration.
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References
Kalia M, Mesulam MM. Brain stem projections of sensory and motor components of the vagus complex in the cat: II. Laryngeal, tracheobronchial, pulmonary, cardiac, and gastrointestinal branches. J Comp Neurol. 1980;193:467–508.
Yoshida Y, Miyazaki T, Hirano M, et al. Arrangement of motoneurons innervating the intrinsic laryngeal muscles of cats as demonstrated by horseradish peroxidase. Acta Otolaryngol. 1982;94:329–34.
Yoshida Y, Yatake K, Tanaka Y, et al. Morphological observation of laryngeal motoneurons by means of cholera toxin B subunit tracing technique. Acta Otolaryngol. 1998;539:98–105.
Fix JD. Cranial nerves. In: Fix JD, editor. Neuroanatomy. 3rd ed. Philadelphia, PA: Lippincott, Williams, & Wilkens; 2002.
Yoshida Y, Saito T, Tanaka Y, et al. The Postganglionic sympathetic innervation of the larynx in cats. In: Gauffin J, Hammerberg B, editors. Vocal Physiology, Acoustic, perceptual, and physiological aspects of voice mechanisms. Singular Publishing Inc: San Diego; 1991. p. 189–96.
Mesulam M. Tetramethyl benzidine for horseradish peroxidase neurohistochemistry, a non-carcinogenic blue reaction-product with superior sensitivity for visualizing neural afferents and efferent. J Histochem Cytochem. 1978;26:106–17.
Myssiorek D. Reucrrent laryngeal nerve paralysis: anatomy and etiology. Otolaryngol Clin Noth Am. 2004;37:25–44.
Gacek RR, Malmgren LT, Lyon MJ. Location of adductor and abductor motor fibers to the larynx. Ann Otol Rhinol Laryngol. 1977;86:770–6.
Mei N, Condamin M, Boyer A. The composition of the vagus nerve of the cat. Cell Tissue Res. 1980;209:423–31.
Evans DHL, Murray JG. Histological and functional studies on the fibre composition of the vagus nerve of the rabbit. J Anat. 1954;88:320–37.
Ogura JH, Lam RL. Anatomical and physiological correlations on stimulating the human superior laryngeal nerve. Laryngoscope. 1953;63:947–59.
Kierner AC, Aigner M, Burium M. The external branch of the superior laryngeal nerve. Arch Otolaryngol Head Neck Surg. 1998;124:301–3.
Kambic V, Zargi M, Radsel Z. Topographical anatomy of the external branch of the superior laryngeal nerve. J Laryngol Otol. 1984;98:1121–4.
Stephens RE, Wendel KH, Addington WR. Anatomy of the internal branch of the superior laryngeal nerve. Clin Anat. 1999;12:79–83.
Tiago R, Pontes P, do Brasil OC. Age-related changes in human laryngeal nerves. Otolaryngol Head Neck Surg. 2007;136:747–51.
Andrew BL. A functional analysis of the myelinated fibres of the superior laryngeal nerve of the rat. J Physiol. 1956;153:420–32.
Kirchner JA, Wyke BD. Afferent discharges from laryngeal articular mechanoreceptors. Nature. 1965;205:86–7.
Sant’Ambrogio G, Mathew OP, Fisher JT, Sant’Ambrogio FB. Laryngeal receptors responding to transmural pressure, airflow, and local muscle activity. Respir Physiol. 1983;54:317–30.
Shin T, Wada S, Maeyama T, et al. Substance P immunoreactive sensory nerve fibers of the canine laryngeal mucosa. In: Fumimora O, editor. Vocal physiology: voice production mechanisms and functions. New York: Raven Press Ltd; 1988. p. 115–27.
Hamamoto T, Takumida M, Hirakawa K, Takeno S, Tatsukawa T. Localization of transient receptor potential channel vanilloid subfamilies in the mouse larynx. Acta Otolaryngol. 2008;128:685–93.
Lee LY, Gu Q. Role of TRPV1 in inflammation-induced airway hypersensitivity. Curr Opin Pharmacol. 2009;9:243–9.
Nadel J, Widdcombe J. Reflex effects of upper airway irritation on total lung resistance and blood pressure. J Appl Physiol. 1962;17:861–5.
Zhang G, et al. Altered expression of trpv1 and sensitivity to capsaicin in pulmonary myelinated afferents following chronic airway inflammation in the rat. J Physiol. 2008;23:5771–86.
Björck G, Margolin G, Måbäck GM, et al. New animal model for assessment of functional laryngeal motor innervation. Ann Otol Rhinol Laryngol. 2012;121(10):695–9.
Wu B, Sanders I, Mu L, et al. The human communicating nerve. Arch Otolaryngol Head Neck Surg. 1994;120:1321–8.
Shin T, Rabuzzi D. Conduction studies of the canine recurrent laryngeal nerve. Laryngoscope. 1971;81:586–96.
Tomasch J, Britton WA. A fiber-analysis of the recurrent laryngeal nerve supply in man. Acta Anat. 1955;23:386–98.
Jotz GP, de Campos D, Rodrigues MF, et al. Histological asymmetry of the human recurrent laryngeal nerve. J Voice. 2005;25:8–14.
Harrison DFN. Fiber size frequency in the recurrent laryngeal nerves of man and giraffe. Acta Otolaryngol. 1981;91:383–9.
Dahlqvist A, Carlsoo B, Hellstrom S. Fiber components of the recurrent laryngeal nerve of the rat: a study by light and electron microscopy. Anat Rec. 1982;204:365–70.
De Campos D, Ellwanger JH, do Nascimento PS, et al. Sexual dimorphism in the human vocal fold innervation. J Voice. 2013;27:267–72.
Sunderland S, Swaney WE. The intraneural topography of the recurrent laryngeal nerve in man. Anat Rec. 1952;114:411–26.
Dubois FS, Foley JO. Experimental studies on the vagus and spinal accessory nerves in the cat. Anat Rec. 1936;64:285–307.
Brocklehurst RJ, Edgeworth FH. The fibers components of the laryngeal nerves of the Macaca mulatta. J Anat. 1940;74:386–9.
Malmgren LT, Gacek RR. Acetylcholinesterase staining of the fiber components in feline and human recurrent laryngeal nerve. Topography of laryngeal motor fiber regions. Acta Otolaryngol. 1981;91:337–52.
Rosenberg SI, Malmgren LT, Woo P. Age-related changes in the internal branch of the rat superior laryngeal nerve. Arch Otolaryngol Head Neck Surg. 1989;115:78–86.
Mortelliti AJ, Malmgren LT, Gacek RR. Ultrastructural changes with age in the human superior laryngeal nerve. Arch Otolaryngol Head Neck Surg. 1990;116:1062–9.
Malmgren LT, Ringwood MA. Aging of the recurrent laryngeal nerve: an ultrastuctural morphometric study. In: Fumimora O, editor. Vocal physiology: voice production mechanisms and functions. New York: Raven Press Ltd; 1988. p. 159–80.
Nakai T, Gogo N, Moriyama H, et al. The human recurrent laryngeal nerve during the aging process. Okajimas Folia Anat Jpn. 2000;76:363–8.
Mueller PB, Sweeney RJ, Baribeau LJ. Acoustic and morphologic study of senescent voice. Ear Nose Throat J. 1984;63:292–5.
Kirchner JA. Laryngeal afferent systems in phonatory control. Proc Conf Access Vocal Pathol. 1981;11:31.
Paniello RC, Edgar JC, Kallogjeri D, et al. Medialization versus reinnervation for unilateral vocal fold paralysis: a multicenter randomized clinical trial. Laryngoscope. 2011;121:2172–9.
Seddon HJ. Three types of nerve injury. Brain. 1943;66(4):237–88.
Sunderland S. A classification of peripheral nerve injuries producing loss of function. Brain. 1951;74:491–516.
George EB, Glass JD, Griffin JW. Axotomy-induced axonal degeneration is mediated by calcium influx through ion-specific channels. J Neurosci. 1995;15:6445–52.
Perry VH, Brown MC, Gordon S. The macrophage response to central and peripheral nerve injury. A possible role for macrophages in regeneration. J Exp Med. 1987;165:1218–23.
Tang S, Shen YJ, DeBellard ME. Myelin-associated glycoprotein interacts with neurons via a sialic acid binding site at ARG118 and a distinct neurite inhibition site. J Cell Biol. 1997;38:1355–66.
Love FM, Son YJ, Thompson WJ. Activity alters muscle reinnervation and terminal sprouting by reducing the number of Schwann cell pathways that grow to link synaptic sites. J Neurobiol. 2003;54(4):566–76.
Kingham PJ, Terenghi G. Bioengineered nerve regeneration and muscle reinnervation. J Anat. 2006;209(4):511–26.
Nomoto M, Yoshihara T, Kanda T, Kaneko T. Synapse formation by autonomic nerves in the previously denervated neuromuscular junctions of the feline intrinsic laryngeal muscles. Brain Res. 1991;539(2):276–86.
Nomoto M, Yoshihara T, Kanda T, Konno A, Kaneko T. Misdirected reinnervation in the feline intrinsic laryngeal muscles after long-term denervation. Acta Otolaryngol Suppl. 1993;506:71–4.
Hydman J, Mattsson P. Collateral reinnervation by the superior laryngeal nerve after recurrent laryngeal nerve injury. Muscle Nerve. 2008;38(4):1280–9.
Halum SL, Macrae B, Bijangi-Vishehsaraei K, et al. Neurotrophic factor-secreting autologous muscle stem cell therapy for the treatment of laryngeal denervation injury. Laryngoscope. 2012;122:2482–96.
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Parker, N.P., Patel, R., Halum, S.L. (2016). Micro-neuroanatomy of the Vagus, Superior Laryngeal, and Recurrent Laryngeal Nerves. In: Randolph, G. (eds) The Recurrent and Superior Laryngeal Nerves. Springer, Cham. https://doi.org/10.1007/978-3-319-27727-1_4
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DOI: https://doi.org/10.1007/978-3-319-27727-1_4
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