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Fertility Conditions Associated with Cancer Development

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Cancer and Fertility

Part of the book series: Current Clinical Urology ((CCU))

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Abstract

Male infertility lies at the intersection of genetic determinants and environmental effects. Although the exact genetic mechanisms of male infertility are still unclear, the associations between male infertility and medical diseases including cancer are clear. The advent of Assisted Reproductive Technology (ART) has allowed men to bypass urologic care to achieve their family planning goals at a time when testicular germ cell tumors (TGCT) in industrialized nations are increasing and semen quality is arguably decreasing. Data suggests that male reproductive failure may be a harbinger of future urologic diseases, including testis and prostate cancer, thus emphasizing the importance of dedicated urologic evaluation and care for all male infertility patients.

Advances in epigenetics, the sequencing of the human genome, and maturation of large datasets from countries with socialized medicine are heralding a new era of medicine and research. The sensitivity of germinal epithelium to changes in the external environment combined with the internal metabolic profile make germinal epithelium an excellent avenue for exploring the intersection between infertility and cancers of the male reproductive tract.

This chapter will review male infertility with specific focus on epidemiologic data and biological mechanisms linking male reproductive health and cancer with specific focus on TGCT and prostate cancer (CaP). We will review the possible biologic mechanisms that may underlie this association.

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  1. Department of Urology, University of Washington, 1959 Northeast Pacific, Box 356510, Seattle, WA, 98195, USA

    Kevin A. Ostrowski M.D. & Thomas J. Walsh M.D., M.S.

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  1. Kevin A. Ostrowski M.D.
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Correspondence to Kevin A. Ostrowski M.D. .

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  1. Lerner College of Medi, Cleveland Clinic, Department of Urology, Cleveland, Ohio, USA

    Edmund S. Sabanegh, Jr.

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Ostrowski, K.A., Walsh, T.J. (2016). Fertility Conditions Associated with Cancer Development. In: Sabanegh, Jr., E. (eds) Cancer and Fertility. Current Clinical Urology. Humana Press, Cham. https://doi.org/10.1007/978-3-319-27711-0_6

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