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Sepsis and Multiple Organ Failure

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The Stress Response of Critical Illness: Metabolic and Hormonal Aspects

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Abstract

Signs of sepsis are systematically present in each critically ill patient after a few days of stay in an intensive care unit.The associated metabolic response includes a rise in expended energy a few after its onset and changes in the use of energy substrates. General recommendations include the preference of the oral or enteral route and a limitation of the caloric intake during the early phase. Nutritional interventions have been assessed to modulate the inflammatory response underlying the metabolic changes, including the addition of supplemental omega-3 fatty acids, glutamine and antioxidants. The beneficial effects of these interventions started during the course of critical illness have not been convincingly confirmed. Hence, no specific diet or nutritional formula is currently recommended.

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Authors and Affiliations

  1. Department of Intensive Care, Erasme University Hospital, Free University of Brussels, 808 route de Lennik, Brussels, 1070, Belgium

    Jean-Charles Preiser MD, PhD

  2. Intensive Care, Centre hospitalier regional La Citadelle, Liege, Belgium

    Vincent Fraipont MD

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  1. Jean-Charles Preiser MD, PhD
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  2. Vincent Fraipont MD
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Correspondence to Jean-Charles Preiser MD, PhD .

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  1. Brussels, Belgium

    Jean-Charles Preiser

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Preiser, JC., Fraipont, V. (2016). Sepsis and Multiple Organ Failure. In: Preiser, JC. (eds) The Stress Response of Critical Illness: Metabolic and Hormonal Aspects. Springer, Cham. https://doi.org/10.1007/978-3-319-27687-8_17

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  • DOI: https://doi.org/10.1007/978-3-319-27687-8_17

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-27685-4

  • Online ISBN: 978-3-319-27687-8

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