Skip to main content

Parameter Synthesis Using Parallelotopic Enclosure and Applications to Epidemic Models

  • Conference paper
  • First Online:
Hybrid Systems Biology (HSB 2014)

Part of the book series: Lecture Notes in Computer Science ((LNBI,volume 7699))

Included in the following conference series:

Abstract

We consider the problem of refining a parameter set to ensure that the behaviors of a dynamical system satisfy a given property. The dynamics are defined through parametric polynomial difference equations and their Bernstein representations are exploited to enclose reachable sets into parallelotopes. This allows us to achieve more accurate reachable set approximations with respect to previous works based on axis-aligned boxes. Moreover, we introduce a symbolical precomputation that leads to a significant improvement on time performances. Finally, we apply our framework to some epidemic models verifying the strength of the proposed method.

This work is partially supported by Istituto Nazionale di Alta Matematica (INdAM) and the project MALTHY (ANR-13-INSE-003).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 34.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 44.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Dreossi, T., Dang, T.: Parameter synthesis for polynomial biological models. In: HSCC 2014, New York, NY, USA, pp. 233–242. ACM (2014)

    Google Scholar 

  2. Dang, T., Testylier, R.: Reachability analysis for polynomial dynamical systems using the Bernstein expansion. Reliable Comput. 17(2), 128–152 (2012)

    MathSciNet  Google Scholar 

  3. Ben Sassi, M.A., Testylier, R., Dang, T., Girard, A.: Reachability analysis of polynomial systems using linear programming relaxations. In: Chakraborty, S., Mukund, M. (eds.) ATVA 2012. LNCS, vol. 7561, pp. 137–151. Springer, Heidelberg (2012)

    Chapter  Google Scholar 

  4. Testylier, R., Dang, T.: Analysis of parametric biological models with non-linear dynamics. In: International Workshop on Hybrid Systems and Biology HSB, EPTCS, vol. 92, pp. 16–29 (2012)

    Google Scholar 

  5. Garloff, J., Smith, A.: Rigorous affine lower bound functions for multivariate polynomials and their use in global optimisation. In: Proceedings of the 1st International Conference on Applied Operational Research. Lecture Notes in Management Science, vol. 1, pp. 199–211 (2008)

    Google Scholar 

  6. Barnat, J., Brim, L., Krejci, A., Streck, A., Safranek, D., Vejnar, M., Vejpustek, T.: On parameter synthesis by parallel model checking. IEEE/ACM Trans. Comput. Biol. Bioinform. 9(3), 693–705 (2012)

    Article  Google Scholar 

  7. Jha, S.K., Langmead, C.J.: Synthesis and infeasibility analysis for stochastic models of biochemical systems using statistical model checking and abstraction refinement. Theor. Comput. Sci. 412(21), 2162–2187 (2011)

    Article  MathSciNet  MATH  Google Scholar 

  8. Bartocci, E., Bortolussi, L., Nenzi, L.: On the robustness of temporal properties for stochastic models. In: HSB 2013, EPTCS, vol. 125 (2013)

    Google Scholar 

  9. Grosu, R., Batt, G., Fenton, F.H., Glimm, J., Le Guernic, C., Smolka, S.A., Bartocci, E.: From cardiac cells to genetic regulatory networks. In: Gopalakrishnan, G., Qadeer, S. (eds.) CAV 2011. LNCS, vol. 6806, pp. 396–411. Springer, Heidelberg (2011)

    Chapter  Google Scholar 

  10. Dreossi, T., Dang, T.: Falsifying oscillation properties of parametric biological models. In: HSB 2013, EPTCS, vol. 125, pp. 53–67 (2013)

    Google Scholar 

  11. Donzé, A.: Breach, a toolbox for verification and parameter synthesis of hybrid systems. In: Touili, T., Cook, B., Jackson, P. (eds.) CAV 2010. LNCS, vol. 6174, pp. 167–170. Springer, Heidelberg (2010)

    Chapter  Google Scholar 

  12. Donzé, A., Clermont, G., Langmead, C.J.: Parameter synthesis in nonlinear dynamical systems: application to systems biology. J. Comput. Biol. 17(3), 325–336 (2010)

    Article  MathSciNet  Google Scholar 

  13. Garloff, J., Smith, A.P.: A comparison of methods for the computation of affine lower bound functions for polynomials. In: Jermann, C., Neumaier, A., Sam, D. (eds.) COCOS 2003. LNCS, vol. 3478, pp. 71–85. Springer, Heidelberg (2005)

    Chapter  Google Scholar 

  14. Sankaranarayanan, S., Sipma, H.B., Manna, Z.: Scalable analysis of linear systems using mathematical programming. In: Cousot, R. (ed.) VMCAI 2005. LNCS, vol. 3385, pp. 25–41. Springer, Heidelberg (2005)

    Chapter  Google Scholar 

  15. Organization, W.H.: Pandemic (h1n1) 2009 - update 103, June 2010. http://www.who.int/csr/don/2010_06_04/en/

  16. Organization, W.H.: Summary of probable sars cases with onset of illness from 1 November 2002 to 31 July 2003, December 2013. http://www.who.int/csr/sars/country/table2004_04_21/en/

  17. Kermack, W., McKendrick, A.: A contribution to the mathematical theory of epidemics. Proc. Roy. Soc. Lond.: Ser. A, Phys. Math. Sci. 115, 700–721 (1927)

    Article  MATH  Google Scholar 

  18. Gumel, A., Ruan, S., Day, T., Watmough, J., Brauer, F., Driessche, V., Gabrielson, D., Bowman, C., Alexander, M., Ardal, S., et al.: Modelling strategies for controlling sars outbreaks. Proc. Roy. Soc. Lond. Ser. B: Biol. Sci. 271(1554), 2223–2232 (2004)

    Article  Google Scholar 

  19. Parra, P.A.G., Lee, S., Velzquez, L., Castillo-Chavez, C.: A note on the use of optimal control on a discrete time model of influenza dynamics. Math. Biosci. Eng. 8(1), 183–197 (2011)

    Article  MathSciNet  MATH  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Tommaso Dreossi .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2015 Springer International Publishing Switzerland

About this paper

Cite this paper

Dang, T., Dreossi, T., Piazza, C. (2015). Parameter Synthesis Using Parallelotopic Enclosure and Applications to Epidemic Models. In: Maler, O., Halász, Á., Dang, T., Piazza, C. (eds) Hybrid Systems Biology. HSB 2014. Lecture Notes in Computer Science(), vol 7699. Springer, Cham. https://doi.org/10.1007/978-3-319-27656-4_4

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-27656-4_4

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-27655-7

  • Online ISBN: 978-3-319-27656-4

  • eBook Packages: Computer ScienceComputer Science (R0)

Publish with us

Policies and ethics