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Targeting Oral Cancer pp 263–281Cite as

Targeting Coagulation Mediators in Head and Neck Cancer

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Abstract

This chapter examines the role of the coagulation system in cancer. While the role of a prothrombotic state was linked to cancer development many years ago, effective targeting of mediators of coagulation is not yet an element of cancer therapy. In the last decade, multiple novel anticoagulants have been approved for use in the prevention or treatment of thrombotic conditions. The presence of a larger armamentarium of medications with fewer bleeding side effects makes them suitable adjuncts in the multimodal treatment of cancer.

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Authors and Affiliations

  1. Fribley-Callaghan Collaboratory, Wayne State University School of Medicine, Detroit, MI, 48201, USA

    Rohith Jesudas MD, Qinghua Zeng PhD, MD, Danielle M. Garshott, Nicholas Yoo & Michael U. Callaghan MD

  2. Division of Hematology Oncology, Carman and Ann Adams Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI, 48201, USA

    Rohith Jesudas MD, Qinghua Zeng PhD, MD & Michael U. Callaghan MD

  3. Carman and Ann Adams Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI, 48201, USA

    Danielle M. Garshott

  4. Fribley-Callaghan Collaboratory, Wayne State University School of Medicine, Detroit, MI, USA

    Andrew M. Fribley PhD

  5. Division of Hematology Oncology, Carman and Ann Adams Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI, USA

    Andrew M. Fribley PhD

  6. Karmanos Cancer Institute, Detroit, MI, USA

    Andrew M. Fribley PhD

  7. Department of Otolaryngology, Head and Neck Surgery, Wayne State University School of Medicine, Detroit, MI, USA

    Andrew M. Fribley PhD

  8. Molecular Therapeutics Group, Karmanos Cancer Institute, Detroit, MI, USA

    Andrew M. Fribley PhD

  9. Department of Pediatrics and Communicable Diseases, University of Michigan School of Medicine, Ann Arbor, MI, 48109, USA

    Jordan A. Shavit MD

  10. Department of Pediatrics, CS Mott Children’s Hospital, University of Michigan, Floor 7, 1540 E Hospital Dr SPC 4257, Ann Arbor, MI, 48109, USA

    Jordan A. Shavit MD

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  1. Rohith Jesudas MD
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  1. School of Medicine, Wayne State University, DETROIT, Michigan, USA

    Andrew M. Fribley

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Jesudas, R. et al. (2016). Targeting Coagulation Mediators in Head and Neck Cancer. In: M. Fribley, A. (eds) Targeting Oral Cancer. Springer, Cham. https://doi.org/10.1007/978-3-319-27647-2_11

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