Skip to main content

Handling of the Surgical Specimen and Pathology Reporting of Penile Neoplasms

  • Chapter
  • First Online:
Pathology of Testicular and Penile Neoplasms

Abstract

The pathology report supplies important information to guide the therapeutic approach and predict prognostic expectations in penile neoplastic disease. It provides the histological diagnosis and subtype as well as other factors affecting prognosis such as histological grade, site or sites of growth, size, thickness, anatomical depth of invasion and vascular or perineural infiltration. In circumcision specimen reports, the margins of resection to be examined are the coronal sulcus, the mucosal and cutaneous margin, whereas in penectomy specimens the urethral/periurethral, corporal, and cutaneous margins have to be investigated.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

eBook
USD 16.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 129.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Pow-Sang MR, Ferreira U, Pow-Sang JM, Nardi AC, Destefano V. Epidemiology and natural history of penile cancer. Urology. 2010;76:S2–6.

    Article  PubMed  Google Scholar 

  2. Pow-Sang MR, Benavente V, Pow-Sang JE, Morante C, Meza L, Baker M, Pow-Sang JM. Cancer of the penis. Cancer Control. 2002;9:305–14.

    PubMed  Google Scholar 

  3. Calmon MF, Tasso Mota M, Vassallo J, Rahal P. Penile carcinoma: risk factors and molecular alterations. Scientific World J. 2011;11:269–82.

    Article  CAS  Google Scholar 

  4. Madsen BS, van den Brule AJ, Jensen HL, Wohlfahrt J, Frisch M. Risk factors for squamous cell carcinoma of the penis – population-based case–control study in Denmark. Cancer Epidemiol Biomarkers Prev. 2008;17:2683–91.

    Article  CAS  PubMed  Google Scholar 

  5. Chaux A, Cubilla AL. Advances in the pathology of penile carcinomas. Hum Pathol. 2012;43:771–89.

    Article  CAS  PubMed  Google Scholar 

  6. Young RH, Srigley JR, Amin MB, Ulbright TM, Cubilla AL. Tumors of the prostate gland, seminal vesicles, male urethra, and penis. AFIP atlas of tumor pathology. 3rd series. Fascicle 28. Washington, DC: AFIP; 2000.

    Google Scholar 

  7. Deem S, Keane T, Bhavsar R, El-Zawahary A, Savage S. Contemporary diagnosis and management of squamous cell carcinoma (SCC) of the penis. BJU Int. 2011;108:1378–92.

    Article  PubMed  Google Scholar 

  8. Solsona E, Bahl A, Brandes SB, Dickerson D, Puras-Baez A, van Poppel H, Watkin NA. New developments in the treatment of localized penile cancer. Urology. 2010;76:S36–42.

    Article  PubMed  Google Scholar 

  9. Velazquez EF, Amin MB, Epstein JI, Grignon DJ, Humphrey PA, Pettaway CA, Renshaw AA, Reuter VE, Srigley JR, Zhou M, Cubilla AL; Members of the Cancer Committee, College of American Pathologists. Protocol for the examination of specimens from patients with carcinoma of the penis. CAP Protocol, web posting date: October 2013.

    Google Scholar 

  10. Chaux A, Velazquez EF, Algaba F, Ayala G, Cubilla AL. Developments in the pathology of penile squamous cell carcinomas. Urology. 2010;76:S7–14.

    Article  PubMed  Google Scholar 

  11. Cubilla AL, Piris A, Pfannl R, Rodriguez I, Agüero F, Young RH. Anatomic levels: important landmarks in penectomy specimens: a detailed anatomic and histologic study based on examination of 44 cases. Am J Surg Pathol. 2001;25:1091–4.

    Article  CAS  PubMed  Google Scholar 

  12. Velazquez EF, Bock A, Soskin A, Codas R, Arbo M, Cubilla AL. Preputial variability and preferential association of long phimotic foreskins with penile cancer: an anatomic comparative study of types of foreskin in a general population and cancer patients. Am J Surg Pathol. 2003;27:994–8.

    Article  PubMed  Google Scholar 

  13. Mikuz G, Winstanley AM, Schulman CC, Debruyne FM, Parkinson CM. Handling and pathology reporting of circumcision and penectomy specimens. Eur Urol. 2004;46:434–9.

    Article  PubMed  Google Scholar 

  14. Edge SB, Byrd DR, Carducci MA, Compton CC, editors. AJCC cancer staging manual. 7th ed. New York: Springer; 2009.

    Google Scholar 

  15. Velazquez EF, Ayala G, Liu H, Chaux A, Zanotti M, Torres J, Cho SI, Barreto JE, Soares F, Cubilla AL. Histologic grade and perineural invasion are more important than tumor thickness as predictor of nodal metastasis in penile squamous cell carcinoma invading 5 to 10 mm. Am J Surg Pathol. 2008;32:974–9.

    Article  PubMed  Google Scholar 

  16. Guimarães GC, Cunha IW, Soares FA, Lopes A, Torres J, Chaux A, Velazquez EF, Ayala G, Cubilla AL. Penile squamous cell carcinoma clinicopathological features, nodal metastasis and outcome in 333 cases. J Urol. 2009;182:528–34.

    Article  PubMed  Google Scholar 

  17. Novara G, Galfano A, De Marco V, Artibani W, Ficarra V. Prognostic factors in squamous cell carcinoma of the penis. Nat Clin Pract Urol. 2007;4:140–6.

    Article  PubMed  Google Scholar 

  18. Emerson RE, Ulbright TM, Eble JN, Geary WA, Eckert GJ, Cheng L. Predicting cancer progression in patients with penile squamous cell carcinoma: the importance of depth of invasion and vascular invasion. Mod Pathol. 2001;14:963–8.

    Article  CAS  PubMed  Google Scholar 

  19. Chaux A, Caballero C, Soares F, Guimarães GC, Cunha IW, Reuter V, Barreto J, Rodríguez I, Cubilla AL. The prognostic index: a useful pathologic guide for prediction of nodal metastases and survival in penile squamous cell carcinoma. Am J Surg Pathol. 2009;33:1049–57.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Rodolfo Montironi .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2016 Springer International Publishing Switzerland

About this chapter

Cite this chapter

Montironi, R. et al. (2016). Handling of the Surgical Specimen and Pathology Reporting of Penile Neoplasms. In: Colecchia, M. (eds) Pathology of Testicular and Penile Neoplasms. Springer, Cham. https://doi.org/10.1007/978-3-319-27617-5_14

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-27617-5_14

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-27615-1

  • Online ISBN: 978-3-319-27617-5

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics