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Head and Neck Cancer pp 163–179Cite as

HPV and EBV in Head and Neck Cancer

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Abstract

The focus of this book chapter is to discuss the role of human papillomavirus (HPV) in head and neck squamous cell carcinoma (HNSCC) and Epstein–Barr virus (EBV) in nasopharyngeal carcinoma (NPC). We have summarized the main events of HPV and EBV life cycle, potential mechanisms of HPV- or EBV-mediated carcinogenesis, and the implications of HPV and EBV in head and neck cancer, with an emphasis on disease diagnosis, prognosis, and therapeutic treatment. The potential of proteomics and metabolomics for studying these virus-associated cancers has also been discussed. A mechanistic understanding of HPV-associated HNSCC or EBV-associated NPC would require profound analysis of these tumors using advanced molecular analysis technologies, which will facilitate the development of preventive and therapeutic strategies for these diseases.

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Authors and Affiliations

  1. School of Dentistry, University of California, Los Angeles, Los Angeles, CA, USA

    Jeffrey Brumbaugh DDS

  2. Otolaryngology-Head and Neck Surgery, University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA

    Robert L. Ferris MD, PhD

  3. School of Dentistry, University of California, Los Angeles, Box 951668, 10833 Le Conte Ave, Los Angeles, CA, 90095, USA

    Shen Hu PhD, MBA

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  1. Jeffrey Brumbaugh DDS
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  2. Robert L. Ferris MD, PhD
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  3. Shen Hu PhD, MBA
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Correspondence to Shen Hu PhD, MBA .

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Editors and Affiliations

  1. Department of Radio-Oncology, Genolier Swiss Medical Network, Genolier, Switzerland

    Jacques Bernier

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Brumbaugh, J., Ferris, R.L., Hu, S. (2016). HPV and EBV in Head and Neck Cancer. In: Bernier, J. (eds) Head and Neck Cancer. Springer, Cham. https://doi.org/10.1007/978-3-319-27601-4_8

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  • DOI: https://doi.org/10.1007/978-3-319-27601-4_8

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