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Head and Neck Cancer pp 555–567Cite as

Diagnosis and Multidisciplinary Treatment of Laryngeal Cancers

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Abstract

Laryngeal cancer is the second most common respiratory cancer after lung cancer in the United States. Most laryngeal squamous cell carcinomas result from prolonged exposure to carcinogens that stimulate mucosal hyperplasia and ultimately lead to carcinoma. The treatment of laryngeal cancer has evolved through several phases, initially relying on surgery as a single modality and then evolving to adjuvant therapies complementing surgery, and more recently, true multimodality approaches tailored to the patient. In this chapter, we will discuss in depth the sequencing of nonsurgical therapies for advanced disease, the role of systemic therapy in general, and the development and approval of anticancer agents. In addition, we will touch on novel, truly investigational approaches and cover aspects of staging and diagnosis, radiation and surgical techniques, as well as supportive care issues.

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Authors and Affiliations

  1. Department of Hematology and Medical Oncology, The Winship Cancer Institute of Emory University, 1365 Clifton Road C2110, Atlanta, GA, 30322, GA, USA

    Nabil F. Saba MD

  2. Department of Otolaryngology, Head and Neck Surgery, Emory University School of Medicine, Atlanta, GA, USA

    J. Trad Wadsworth MD, MBA, FACS

  3. Departments of Radiation Oncology, Otolaryngology, Hematology and Medical Oncology, The Winship Cancer Institute of Emory University, Atlanta, USA

    Jonathan J. Beitler MD, MBA, FACR, FASTRO

  4. Department of Hematology and Medical Oncology, President American University of Beirut, Emory University School of Medicine, Atlanta, GA, USA

    Fadlo R. Khuri MD

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  1. Nabil F. Saba MD
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  2. J. Trad Wadsworth MD, MBA, FACS
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  3. Jonathan J. Beitler MD, MBA, FACR, FASTRO
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  4. Fadlo R. Khuri MD
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Correspondence to Jonathan J. Beitler MD, MBA, FACR, FASTRO .

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  1. Department of Radio-Oncology, Genolier Swiss Medical Network, Genolier, Switzerland

    Jacques Bernier

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Saba, N.F., Wadsworth, J.T., Beitler, J.J., Khuri, F.R. (2016). Diagnosis and Multidisciplinary Treatment of Laryngeal Cancers. In: Bernier, J. (eds) Head and Neck Cancer. Springer, Cham. https://doi.org/10.1007/978-3-319-27601-4_30

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