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Translational Toxicology pp 295–319Cite as

The Impact of Environmental Stressors on DNA Methylation, Neurobehavioral Development, and Chronic Physical Aggression: Prospects for Early Protective Interventions

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Part of the book series: Molecular and Integrative Toxicology ((MOLECUL))

Abstract

There is now convincing evidence from prospective and retrospective epidemiological studies that prenatal and early post-natal stressors have long term impacts on life span health and well-being. Unraveling the mechanisms by which early environmental stressors have an impact on DNA methylation and neurobehavioral development should provide the foundation for creating effective early protective interventions. We review the recent convergence of four research domains to explain the mechanisms leading to chronic physical aggression (behavior development, epigenetics, serotonin neurotransmission and immunology) and we discuss the next generation of studies that are needed to identify effective pre and post natal preventive interventions.

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Authors and Affiliations

  1. School of Public Health, University College Dublin, Belfield, Dublin, Ireland

    Richard E. Tremblay Ph.D.

  2. Université de Montréal, 3050, Édouard-Montpetit Blvd, Montréal, QC, H3T 1J7, Canada

    Richard E. Tremblay Ph.D.

  3. Department of Psychology, Concordia University, 7141 Sherbrooke St. West, Montreal, QC, H4B 1R6, Canada

    Linda Booij Ph.D.

  4. CHU Sainte-Justine, 3175 Chemin de la Côte Sainte-Catherine, Montréal, QC, Canada

    Linda Booij Ph.D.

  5. Max Planck Institute of Psychiatry, Kraepelinstr. 2-10, 80804, Munich, Germany

    Nadine Provençal Ph.D.

  6. Department of Pharmacology and Therapeutics, McGill Faculty of Medicine, McIntyre Medical Building, 3655 Prom. Sir-William-Osler, Room 1309/1310, Montreal, QC, H3G 1Y6, Canada

    Moshe Szyf Ph.D.

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  1. Therapeutic Science & Strategy Unit, Quintiles Inc., MORRISVILLE, North Carolina, USA

    Claude L. Hughes

  2. Michael Waters Consulting, Hillsborough, North Carolina, USA

    Michael D. Waters

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Tremblay, R.E., Booij, L., Provençal, N., Szyf, M. (2016). The Impact of Environmental Stressors on DNA Methylation, Neurobehavioral Development, and Chronic Physical Aggression: Prospects for Early Protective Interventions. In: Hughes, C., Waters, M. (eds) Translational Toxicology. Molecular and Integrative Toxicology. Humana Press, Cham. https://doi.org/10.1007/978-3-319-27449-2_10

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