Skip to main content
SpringerLink
Log in

Diffuse Large B-Cell Lymphoma in Children and Adolescents (B Mature): Introduction

  • Chapter
  • First Online:
PET/CT in Lymphomas

  • 1111 Accesses

Abstract

Diffuse large B-cell lymphoma (DLBCL) is a mature B-cell neoplasm, which accounts for approximately 10–20 % of paediatric NHL [1]. In fact, this definition represents a morphologically, immunologically and clinically heterogeneous group of lymphoid neoplasms, rather than one entity [2]. In contrast to other childhood NHL, there is no specific genetic feature for DLBCL. The recent WHO classification delineated some newly defined entities on the basis of distinctive clinical, pathologic or biologic features.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 99.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 129.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 129.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Percy CL, Smith MA, Linet M et al (1999) Lymphomas and reticuloendothelial neoplasms. In: Ries LA, Smith MA, Gurney JG et al (eds) Cancer incidence and survival among children and adolescents: United States SEER Program 1975–1995. National Cancer Institute, SEER Program, Bethesda, pp 35–50, NIH Pub.No. 99–4649

    Google Scholar 

  2. Jaffe ES, Harris NL, Stein H et al (2008) Introduction and overview of the classification of the lymphoid neoplasms. In: Swerdlow SH, Campo E, Harris NL et al (eds) WHO classification of tumours of haematopoietic and lymphoid tissues, 4th edn. International Agency for Research on Cancer, Lyon, pp 157–166

    Google Scholar 

  3. Stein H, Warnke RA, Chan WC (2008) Diffuse large B-cell lymphoma (DLBCL), NOS. In: Swerdlow SH, Campo E, Harris NL et al (eds) WHO classification of tumours of haematopoietic and lymphoid tissues, 4th edn. International Agency for Research on Cancer, Lyon, pp 233–237

    Google Scholar 

  4. Reiter A, Klapper W (2008) Recent advances in the understanding and management of diffuse large B-cell lymphoma in children. Br J Haematol 142(3):329–347

    Article  CAS  PubMed  Google Scholar 

  5. Miles RR, Raphael M, McCarthy K et al (2008) Pediatric diffuse large B-cell lymphoma demonstrates a high proliferation index, frequent c-Myc protein expression, and a high incidence of germinal centre subtype: Report of the French-American-British (FAB) international study group. Pediatr Blood Cancer 51(3):369–374

    Article  PubMed  PubMed Central  Google Scholar 

  6. Oschlies I, Klapper W, Zimmermann M et al (2006) Diffuse large B-cell lymphoma in pediatric patients belongs predominantly to the germinal-centre type B-cell lymphomas: a clinicopathologic analysis of cases included in the German BFM (Berlin-Frankfurt-Munster) Multicenter Trial. Blood 107(10):4047–4052

    Article  CAS  PubMed  Google Scholar 

  7. Campo E, Swerdlow S, Harris N et al (2011) The 2008 WHO classification of lymphoid neoplasms and beyond: evolving concepts and practical applications. Blood 117(19):5019–5032

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Oschlies I, Burkhardt B, Salaverria I et al (2011) Clinical, pathological and genetic features of primary mediastinal large B-cell lymphomas and mediastinal gray zone lymphomas in children. Haematologica 96(2):262–268

    Article  PubMed  PubMed Central  Google Scholar 

  9. Gerrard M, Waxman I, Sposto R et al (2013) Outcome and pathologic classification of children and adolescents with mediastinal large B-cell lymphoma treated with FAB/LMB96 mature B-NHL therapy. Blood 121(2):278–285

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Burkhardt B, Oschlies I, Klapper W et al (2011) Non-Hodgkin’s lymphoma in adolescents: experiences in 378 adolescent NHL patients treated according to pediatric NHL-BFM protocols. Leukemia 25(1):153–160

    Article  CAS  PubMed  Google Scholar 

  11. Klapper W et al (2012) Patient age at diagnosis is associated with the molecular characteristics of diffuse large B-cell lymphoma. Blood 119(8):1882–1887

    Article  CAS  PubMed  Google Scholar 

  12. Childhood Non-Hodgkin Lymphoma Treatment (PDQ). www.cancer.gov/types/lymphoma/hp/child-nhl-treatment-pdq

  13. Poirel HA et al (2009) Specific cytogenetic abnormalities are associated with a significantly inferior outcome in children and adolescents with mature B-cell non-Hodgkin’s lymphoma: results of the FAB/LMB 96 international study. Leukemia 23(2):323–331

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Martelli M et al (2014) [18F]fluorodeoxyglucose positron emission tomography predicts survival after chemoimmunotherapy for primary mediastinal large B-cell lymphoma: results of the international extranodal lymphoma study group IELSG-26 study. J Clin Oncol 32(17):1769–1775

    Article  PubMed  Google Scholar 

  15. Moskowitz GH et al (2010) Risk-adapted dose-dense immunochemotherapy determined by interim FDG-PET in advanced-stage diffuse large B-cell lymphoma. J Clin Oncol 28(11):1896–1903

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  16. Nagle SJ et al (2015) The role of FDG-PET imaging as a prognostic marker of outcome in primary mediastinal B-cell lymphoma. Cancer Med 4(1):7–15

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. Heeren JHM, Croonen AM, Pijnenborg JMA (2008) Primary extranodal marginal zone B-cell lymphoma of the female genital tract: a case report and literature review. Int J Gynecol Path 27:243–246

    Google Scholar 

  18. Ahmad AK, Hui P, Litkouhi B et al (2014) Institutional review of primary non-Hodgkin lymphoma of the female genital tract: a 33-year experience. Int J Gynecol Cancer 24(7):1250–1255

    Article  PubMed  Google Scholar 

  19. Schoder H, Noy A, Gonen M et al (2005) Intensity of 18fluorodeoxyglucose uptake in positron emission tomography distinguishes between indolent and aggressive non-Hodgkin’s lymphoma. J Clin Oncol 23:4643–4651

    Article  PubMed  Google Scholar 

  20. Coughlan M, Elstrom R (2014) The use of FDG-PET in diffuse large B cell lymphoma (DLBCL): predicting outcome following first line therapy. Cancer Imaging 14:34

    Article  PubMed  PubMed Central  Google Scholar 

  21. Armitage JO (2012) My treatment approach to patients with diffuse large B-cell lymphoma. Mayo Clin Proc 87(2):161–171

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  22. Glotzbecker MP et al (2006) Primary non-Hodgkin’s lymphoma of bone in children. J Bone Joint Surg Am 88(3):583–594

    Article  PubMed  Google Scholar 

  23. Zhao XF et al (2007) Pediatric primary bone lymphoma – diffuse large B-cell lymphoma. Morphologic and immunohistochemical characteristics of 10 cases. Am J Clin Pathol 127:47–54

    Article  PubMed  Google Scholar 

  24. Bhojwani D et al (2015) The role of FDG-PET/CT in the evaluation of residual disease in paediatric non-Hodgkin lymphoma. Br J Haematol 168(6):845–853

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  25. Qiu L et al (2013) The role of 18F-FDG PET and 18F-FDG PET/CT in the evaluation of pediatric Hodgkin’s lymphoma and non-Hodgkin’s lymphoma. Hell J Nucl Med 16(3):230–236

    PubMed  Google Scholar 

  26. Rhodes MM et al (2006) Utility of FDG-PET/CT in follow-up of children treated for Hodgkin and non-Hodgkin lymphoma. J Pediatr Hematol Oncol 28(5):300–306

    Article  PubMed  Google Scholar 

  27. Bakhshi S et al (2012) Pediatric nonlymphoblastic non-Hodgkin lymphoma: baseline, interim, and posttreatment PET/CT versus contrast-enhanced CT for evaluation – a prospective study. Radiology 263(3):956–968

    Article  Google Scholar 

  28. Patte C, Auperin A, Gerrard M, Michon J, Pinkerton R, Sposto R, Weston C, Raphael M, Perkins SL, McCarthy K, Cairo MS (2007) Results of the randomized international FAB/LMB96 trial for intermediate risk B-cell non-Hodgkin lymphoma in children and adolescents: it is possible to reduce treatment for the early responding patients. Blood 109:2773–2780

    CAS  PubMed  PubMed Central  Google Scholar 

  29. Kazama H, Teramura M, Yoshinaga K, Masuda A (2012) B-cell lymphoma treated with high-dose chemotherapy rescued by in vivo rituximab-purged autologous stem cells. Case Rep Med 2012:Article ID 957063

    Google Scholar 

  30. Oschlies I, Salaverria I, Mahn F, Meinhardt A, Zimmermann M, Woessmann W, Burkhardt B, Gesk S, Krams M, Reiter A, Siebert R, Klapper W (2010) Pediatric follicular lymphoma – a clinico-pathological study of a population-based series of patients treated within the non-Hodgkin’s Lymphoma – Berlin-Frankfurt-Münster (NHL-BFM) multicenter trials. Haematologica 95:253–259

    Article  PubMed  PubMed Central  Google Scholar 

  31. Swerdlow SH (2004) Pediatric follicular lymphomas, marginal zone lymphomas, and marginal zone hyperplasia. Am J Clin Pathol 122(Suppl 1):S98–S109

    PubMed  Google Scholar 

  32. Louissaint A Jr, Ackerman AM, Dias-Santagata D, Ferry JA, Hochberg EP, Huang MS et al (2012) Pediatric-type nodal follicular lymphoma: an indolent clonal proliferation in children and adults with high proliferation index and no BCL2 rearrangement. Blood 120(12):2395–2404

    Article  CAS  PubMed  Google Scholar 

  33. Attarbaschi A, Beishuizen A, Mann G, Rosolen A, Mori T, Uyttebroeck A, Niggli F, Csoka M, Krenova Z, Mellgren K et al (2013) Children and adolescents with follicular lymphoma have an excellent prognosis with either limited chemotherapy or with a “watch and wait” strategy after complete resection. Ann Hematol 92(11):1537–1541

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgments

Case 1: Mediastinum

The authors thank Antonios Kattamis and Natalia Tourkantoni, 1st University Department of Pediatrics, and Kalliopi Stefanaki, Pathology Laboratory, of Athens ‘Aghia Sofia’ Children’s Hospital, for their contribution by sharing the clinical, pathology and imaging data of their patient.

Case 2: Abdomen

The authors are indebted to N. Tourkantoni, K. Katsibardi and A. Kattamis, First Department of Pediatrics, National and Kapodistrian University of Athens, Division of Hematology – Oncology, for sharing clinical and imaging information of their patient.

Case 5: Peripheral Lymph Nodes

The authors thank Antonios Kattamis, Natalia Tourkantoni, Tania Vlachou, First Department of Pediatrics, University of Athens ‘Aghia Sofia’ Children’s Hospital, and Kalliopi Stefanaki, Pathology Laboratory of Athens ‘Aghia Sofia’ Children’s Hospital, for their contribution by sharing the clinical, pathologic and imaging data of their patient.

Author information

Authors and Affiliations

  1. Oncology Department, Children’s Hospital “P. & A. Kyriakou”, Levadias 8, Athens, 11527, Greece

    Marina K. Servitzoglou

  2. Pediatric Oncology Department, “MITERA” Hospital, Kifissias Av. & E. Stavrou 4, Maroussi, 15123, Greece

    Helen Dana

  3. Oncology Department, Children’s Hospital P.& A. Kyriakou, Levadias 8 Street, Athens, 11527, Greece

    Apostolos G. Pourtsidis

  4. Department of Nuclear Medicine, “HYGEIA” Hospital, Kifissias Av. & E. Cross 4, Maroussi, 15123, Greece

    Fani J. Vlachou

  5. Radiology Department, “EVANGELISMOS” General Hospital, Ipsilantou 45-47, Athens, 10676, Greece

    Demetrios N. Exarhos

Authors
  1. Marina K. Servitzoglou
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Helen Dana
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Apostolos G. Pourtsidis
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Fani J. Vlachou
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Demetrios N. Exarhos
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Marina K. Servitzoglou or Marina K. Servitzoglou .

Editor information

Editors and Affiliations

  1. Hygeia and Mitera Hospital, Athens, Greece

    John A. Andreou

  2. Hygeia Hospital, Medical Oncology Department, Athens, Greece

    Paris A. Kosmidis

  3. National & Kapodistrian University, Radiology (emeritus), Athens, Greece

    Athanasios D. Gouliamos

Rights and permissions

Reprints and permissions

Copyright information

© 2016 Springer International Publishing Switzerland

About this chapter

Cite this chapter

Servitzoglou, M.K., Dana, H., Pourtsidis, A.G., Vlachou, F.J., Exarhos, D.N. (2016). Diffuse Large B-Cell Lymphoma in Children and Adolescents (B Mature): Introduction. In: Andreou, J., Kosmidis, P., Gouliamos, A. (eds) PET/CT in Lymphomas. Springer, Cham. https://doi.org/10.1007/978-3-319-27380-8_21

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-27380-8_21

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-27378-5

  • Online ISBN: 978-3-319-27380-8

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation