Skip to main content

Burkitt and Burkitt-Like Lymphomas in Children and Adolescents (Sporadic or Endemic B Mature): Introduction

  • Chapter
  • First Online:
PET/CT in Lymphomas

Abstract

Burkitt and Burkitt-like lymphomas (BL) account for 30–40 % of childhood NHL [1, 2]. It is the most common childhood cancer in equatorial Africa [3]. About 2.5 new cases per one million individuals occur every year worldwide. There is a definite predominance of boys over girls, with the ratios ranging from 1.3 to 8.8:1 [2, 4]. The peak age is between 4 and 7 years [4].

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 99.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 129.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 129.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Percy CL, Smith MA, Linet M et al (1999) Lymphomas and reticuloendothelial neoplasms. In: Ries LA, Smith MA, Gurney JG et al (eds) Cancer incidence and survival among children and adolescents: United States SEER Program 1975–1995. National Cancer Institute, SEER Program, Bethesda, pp 35–50, NIH Pub.No. 99–4649

    Google Scholar 

  2. Leoncini L, Raphael M, Stein H (2008) Burkitt lymphoma. In: Swerdlow SH, Campo E, Harris NL et al (eds) WHO classification of tumours of haematopoietic and lymphoid tissues, 4th edn. International Agency for Research on Cancer, Lyon, pp 262–264

    Google Scholar 

  3. Dong HY (2010) Aggressive B-cell lymphomas: diffuse large B-cell lymphoma and Burkitt lymphoma. In: Jones D (ed) Neoplastic hematopathology: contemporary hematology, vol Part 3. Humana Press, New York, pp 303–322.

    Google Scholar 

  4. Mbulaiteye SM, Biggar RJ, Bhatia K et al (2009) Sporadic childhood Burkitt lymphoma incidence in the United States during 1992–2005. Pediatr Blood Cancer 53(3):366–370

    Article  PubMed  PubMed Central  Google Scholar 

  5. Diebold J, Jaffe ES, Raphael M et al (2001) Burkitt lymphoma. In: Jaffe ES, Harris NL, Stein H et al (eds) World health organization classification of tumours: pathology and genetics of tumours of haematopoietic and lymphoid tissues. IARC Press, Lyon, pp 181–184

    Google Scholar 

  6. Dave SS, Fu K, Wright GW et al (2006) Molecular diagnosis of Burkitt’s lymphoma. N Engl J Med 354:2431–2442

    Article  CAS  PubMed  Google Scholar 

  7. Cairo MS, Sposto R, Perkins SL et al (2003) Burkitt’s and Burkitt-like lymphoma in children and adolescents: a review of the Children’s Cancer Group experience. Br J Haematol 120:660–670

    Article  PubMed  Google Scholar 

  8. Knowles DM (2003) Etiology and pathogenesis of AIDS-related non-Hodgkin’s lymphoma. Hematol Oncol Clin North Am 17:785–820

    Article  PubMed  Google Scholar 

  9. Miles R, Arnold S, Cairo M (2012) Risk factors and treatment of childhood and adolescent Burkitt lymphoma/leukaemia. Br J Hematol 156:730–743

    Article  CAS  Google Scholar 

  10. El-Mallawany N, Cairo M (2015) Advances in the diagnosis and treatment of childhood and adolescent B-cell non-Hodgkin lymphoma. Clin Adv Hematol Oncol 13(2):113–123

    PubMed  Google Scholar 

  11. Mussolin L, Pillon M, d’Amore ES et al (2011) Minimal disseminated disease in high-risk Burkitt’s lymphoma identifies patients with different prognosis. J Clin Oncol 29(13):1779–1784

    Article  PubMed  Google Scholar 

  12. Cairo MS, Sposto R, Gerrard M et al (2012) Advanced stage, increased lactate dehydrogenase, and primary site, but not adolescent age (≥15 years), are associated with an increased risk of treatment failure in children and adolescents with mature B-cell non-Hodgkin’s lymphoma: results of the FAB LMB 96 study. J Clin Oncol 30(4):387–393

    Article  PubMed  PubMed Central  Google Scholar 

  13. Poirel HA, Cairo MS, Heerema NA et al (2009) Specific cytogenetic abnormalities are associated with a significantly inferior outcome in children and adolescents with mature B-cell non-Hodgkin’s lymphoma: results of the FAB/LMB 96 international study. Leukemia 23(2):323–331

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Reiter A (2007) Diagnosis and treatment of childhood non-Hodgkin lymphoma. Am Soc Hematol Educ Program 1:285–296

    Google Scholar 

  15. Uslu L, Donig J, Link M et al (2015) Value of 18F-FDG PET and PET/CT for evaluation of pediatric malignancies. J Nucl Med 56:274–286

    Article  PubMed  Google Scholar 

  16. Sioka C (2013) The utility of FDG PET in diagnosis and follow-up of lymphoma in childhood. Eur J Pediatr 172(6):733–738

    Article  PubMed  Google Scholar 

  17. Bailly C, Eugene T, Couec M-L et al (2014) Prognostic value and clinical impact of 18FDG-PET in the management of children with Burkitt lymphoma after induction chemotherapy. Front Med (Lausanne) 1:54

    Google Scholar 

  18. Mody R, Bui C, Hutchinson R et al (2007) Comparison of 18F Flurodeoxyglucose PET with Ga-67 scintigraphy and conventional imaging modalities in pediatric lymphoma. Leuk Lymphoma 48(4):699–707

    Article  CAS  PubMed  Google Scholar 

  19. Bhowjani B, McCarville MB, Choi JK et al (2015) The role of FDG-PET/CT in the evaluation of residual disease in pediatric non-Hodgkin lymphoma. Br J Haematol 168(6):845–853

    Article  Google Scholar 

  20. Qiu L, Chen Y, Wu J (2013) The role of 18F-FDG PET and 18F-FDG PET/CT in the evaluation of pediatric Hodgkin’s lymphoma and non-Hodgkin’s lymphoma. Hell J Nucl Med 16(3):230–236

    PubMed  Google Scholar 

  21. Riad R, Omar W, Kotb M et al (2010) Role of PET/CT in malignant pediatric lymphoma. Eur J Nucl Med Mol Imaging 37:319–329

    Article  PubMed  Google Scholar 

  22. Kluge R, Kurch L, Montravers F, Mauz-Korholz C (2013) FDG PET/CT in children and adolescents with lymphoma. Pediatr Radiol 43(4):406–417

    Article  PubMed  Google Scholar 

  23. Childhood non-Hodgkin lymphoma treatment (PDQ). www.cancer.gov/types/lymphoma/hp/child-nhl-treatment-pdq

  24. Patte C et al (1986) Improved survival rate in children with stage III and IV B cell non-Hodgkin’s lymphoma and leukemia using multi-agent chemotherapy: results of a study of 114 children from the French Pediatric Oncology Society. J Clin Oncol 4(8):1219–1226

    CAS  PubMed  Google Scholar 

  25. Patte C et al (2007) Results of the randomized international FAB/LMB96 trial for intermediate risk B-cell non-Hodgkin lymphoma in children and adolescents: it is possible to reduce treatment for the early responding patients. Blood 109(7):2773–2780

    CAS  PubMed  PubMed Central  Google Scholar 

  26. Binkovitz L PET/CT imaging of pediatric lymphoma: what’s the evidence? www.snmmi.files.cms-plus.com/

  27. Moulin-Romsee G et al (2010) (18)F-FDG PET/CT bone/bone marrow findings in Hodgkin’s lymphoma may circumvent the use of bone marrow trephine biopsy at diagnosis staging. Eur J Nucl Med Mol Imaging 37(6):1095–1105

    Article  PubMed  Google Scholar 

  28. Bhojwani D et al (2015) The role of FDG-PET/CT in the evaluation of residual disease in paediatric non-Hodgkin lymphoma. Br J Haematol 168(6):845–853

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  29. Rhodes MM et al (2006) Utility of FDG-PET/CT in follow-up of children treated for Hodgkin and non-Hodgkin lymphoma. J Pediatr Hematol Oncol 28(5):300–306

    Article  PubMed  Google Scholar 

Download references

Acknowledgements

Case 2: Abdomen

The authors thank N. Tourkantoni, A. Vlachou, A. Kattamis, First Department of Pediatrics, National and Kapodistrian University of Athens, Division of Hematology–Oncology for their contribution, by sharing clinical and imaging data of their patients.

Case 3: Head and Neck & Bone Marrow

The authors thank Antonios Kattamis and Natalia Tourkantoni, 1st University Department of Pediatrics and Kalliopi Stefanaki, Pathology Laboratory of Athens “Aghia Sofia” Children’s Hospital for their contribution by sharing the clinical, pathology, and imaging data of their patient.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Theodore A. Pipikos .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2016 Springer International Publishing Switzerland

About this chapter

Cite this chapter

Servitzoglou, M.K., Dana, H., Pipikos, T.A., Papaioannou, G.C. (2016). Burkitt and Burkitt-Like Lymphomas in Children and Adolescents (Sporadic or Endemic B Mature): Introduction. In: Andreou, J., Kosmidis, P., Gouliamos, A. (eds) PET/CT in Lymphomas. Springer, Cham. https://doi.org/10.1007/978-3-319-27380-8_20

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-27380-8_20

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-27378-5

  • Online ISBN: 978-3-319-27380-8

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics