Abstract
Primary sclerosing cholangitis (PSC) has a variable clinical course, but often becomes a progressive disease that leads to chronic cholestasis, cirrhosis and liver failure. In addition, PSC is the most common risk factor for cholangiocarcinoma in western countries. The etiology is unclear, and as a result there are no specific medical therapies that change long-term outcomes. Liver transplantation offers the only potentially curative therapy but it is usually reserved for patients with advanced stage or cirrhosis. Earlier stages require alternative invasive treatment modalities to manage symptoms and address dominant strictures, which can be benign or malignant. The distinction between these may be extremely challenging, and has an influence on the treatment options, which include endoscopic dilatation, stenting, or surgery, either biliary bypass or extrahepatic bile duct resection. Endoscopic therapy has less morbidity, but surgical treatment has the advantage of not leaving potentially malignant or dysplastic strictures in place and may be associated with longer survival. When cholangiocarcinoma develops, it tends to appear at an advanced stage and prognosis is poor.
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References
Koro NS, Alkaade S. Role of endoscopy in primary sclerosing cholangitis. Curr Gastroenterol Rep. 2003;15:361.
Aljiffry M, Renfrew PD, Walsh MJ, Laryea M, Molinari M. Analytical review of diagnosis and treatment strategies for dominant bile duct strictures in patients with primary sclerosing cholangitis. HPB (Oxf). 2011;13:79–90.
Van Milligen de Wit AW, Rauws EA, van Bracht J, et al. Endoscopic stent therapy for dominant extrahepatic bile duct strictures in primary sclerosing cholangitis. Gastrointest Endosc. 1996;44:293–9.
Olsson RG, Asztely MS. Prognostic value of cholangiography in primary sclerosing cholangitis. Eur J Gastroenterol Hepatol. 1995;7:251–4.
Stiehl A, Rudolph G, Kloters-Plachky P, Sauer P, Walker S, et al. Development of dominant bile duct stenoses in patients with primary sclerosing cholangitis treated with ursodeoxycholic acid: outcome after endoscopic treatment. J Hepatol. 2002;36:151–6.
Tischendorf JJ, Kruger M, Trautwein C, et al. Cholangioscopic characterization of dominant bile duct stenoses in patients with primary sclerosing cholangitis. Endoscopy. 2006;38:665–9.
Ponsloen CY, Lam K, van Milligen de Witt AW, Hulbregtse K, Tytgat GN. Four years experience with short-term stenting in primary sclerosing cholangitis. Am J Gastroenterol. 1999;94:2403–7.
Baluyut AR, Sherman S, Lehrman GA, Hoen H, Chalasani N. Impact of endoscopic therapy on the survival of patients with primary sclerosing cholangitis. Gastrointest Endosc. 2001;53:308–12.
Gotthardt DN, Rudolph G, Kloters-Plachky P, Kulaksiz H, Stiehl A. Endoscopic dilation of dominant stenoses in primary sclerosing cholangitis: outcome after long-treatment. Gastrointest Endosc. 2010;71:527–34.
LaRusso NF, Shneider BL, Black D, et al. Primary sclerosing cholangitis: summary of a workshop. Hepatology. 2006;44:746–64.
Kaya M, Petersen BT, Angulo P, et al. Balloon dilation compared to stenting of dominant strictures in primary sclerosing cholangitis. Am J Gastroenterol. 2001;96:1059–66.
Domanjko B, Ahrendt SA. Indications for non-transplant surgery in primary sclerosing cholangitis. HPB. 2005;7:292–7.
Pitt HA, Thompson HH, Tompkins RK, Longmire WP. Primary sclerosing cholangitis: results of an aggressive surgical approach. Ann Surg. 1982;196:259–68.
Ahrendt SA, Pitt HA, Kalloo AN, et al. Primary sclerosing cholangitis. Resect, dilate or transplant? Ann Surg. 1998;227:412–23.
Martin FM, Rossi RL, Nugent FW, et al. Surgical aspects of sclerosing cholangitis. Results in 178 patients. Ann Surg. 1990;212:551–6.
Ismail T, Angrisani L, Powell JE, et al. Primary sclerosing cholangitis: surgical options, prognostic variables and outcome. Br J Surg. 1991;78:564–7.
Farges O, Malassagne B, Sebaugh M, Bismuth H. Primary sclerosing cholangitis: liver transplantation or biliary surgery. Surgery. 1995;117:146–55.
Brandsaeter B, Friman S, Broome U, et al. Outcome following liver transplantation for primary sclerosing cholangitis in the Nordic countries. Scand J Gastroenterol. 2003;38:1776–83.
Pawlik TM, Olbrecht VA, Pitt HA, et al. Primary sclerosing cholangitis: role of extrahepatic biliary resection. J Am Coll Surg. 2008;206:822–32.
Myburgh JA. Surgical biliary drainage in primary sclerosing cholangitis. The role of the Hepp-Couinaud approach. Arch Surg. 1994;129:1057–62.
Hutson DG, Russell E, Levi JU, et al. Dilatation of biliary strictures through the afferent limb of a Roux-en-Y choledochojejunostomy in patients with sclerosing cholangitis. World J Surg. 2001;25:1251–3.
Bergquist A, Ekbom A, Olsson R, et al. Hepatic and extrahepatic malignancies in primary sclerosing cholangitis. J Hepatol. 2002;36:321–7.
Abu-Elmagd KM, Selby R, Iwatsuki S, et al. Cholangiocarcinoma and sclerosing cholangitis: clinical characteristics and effect on survival after transplantation. Transplant Proc. 1993;25:1124–9.
Lee JG, Schutz SM, England RE, Leung JW, Cotton PB. Endoscopic therapy of sclerosing cholangitis. Hepatology. 1995;21:661–7.
Rosen CB, Nagorney DM, Wiesner RH, Coffey RJ, LaRusso NF. Cholangiocarcinoma complicating primary sclerosing cholangitis. Ann Surg. 1991;213:21–5.
Eloubeidi MA, Chen VK, Jhala NC, et al. Endoscopic ultrasound-guided fine needle aspiration biopsy of suspected cholangiocarcinoma. Clin Gastroenterol Hepatol. 2004;2:209–13.
Kipp BR, Stadheim LM, Halling SA, et al. A comparison of routine cytology and fluorescence in situ hybridization for the detection of malignant bile duct strictures. Am J Gastroenterol. 2004;99:1675–81.
Linder S, Soderlund C. Endoscopic therapy in primary sclerosing cholangitis: outcome of treatment and risk of cancer. Hepatogastroenterology. 2001;48:387–92.
Chalasani N, Baluyut A, Ismail A, et al. Cholangiocarcinoma in patients with primary sclerosing cholangitis: a multicenter case-control study. Hepatology. 2000;31:7–11.
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Barreto, J.C., Millis, J.M. (2016). When Is Bile Duct Resection Indicated for Biliary Strictures in Primary Sclerosing Cholangitis?. In: Millis, J., Matthews, J. (eds) Difficult Decisions in Hepatobiliary and Pancreatic Surgery. Difficult Decisions in Surgery: An Evidence-Based Approach. Springer, Cham. https://doi.org/10.1007/978-3-319-27365-5_28
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