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Modified Nucleic Acids pp 189–207Cite as

Non-covalent Modification of Double-Stranded DNA at the Mismatch and Bulged Site

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Part of the book series: Nucleic Acids and Molecular Biology ((NUCLEIC,volume 31))

Abstract

Advances in synthetic chemistry of DNA allow us to create DNAs with chemical modifications that endow unnatural properties and functions. There is another way for chemical modification: non-covalent modification with DNA-binding molecule. Instead of the covalently introduced functionalities, DNA is modified by non-covalent binding of small molecules bearing desired functionalities. We have developed synthetic ligands that selectively bind to mismatched base pair and unpaired bulge in double-stranded DNA, which is requisite for delivering the functions at a particular location of DNA. This chapter describes the non-covalent modification of target DNA by our mismatch- and bulge-binding ligands bearing various functionalities.

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Authors and Affiliations

  1. The Institute of Scientific and Industrial Research, Osaka University, 8-1 Mihoga-oka, Ibaraki, 567-0047, Japan

    Chikara Dohno & Kazuhiko Nakatani

Authors
  1. Chikara Dohno
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  2. Kazuhiko Nakatani
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Correspondence to Kazuhiko Nakatani .

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Editors and Affiliations

  1. The Institute of Scientific and Industri, Osaka University, Ibaraki, Osaka, Japan

    Kazuhiko Nakatani

  2. University of California, San Diego, La Jolla, California, USA

    Yitzhak Tor

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Dohno, C., Nakatani, K. (2016). Non-covalent Modification of Double-Stranded DNA at the Mismatch and Bulged Site. In: Nakatani, K., Tor, Y. (eds) Modified Nucleic Acids. Nucleic Acids and Molecular Biology, vol 31. Springer, Cham. https://doi.org/10.1007/978-3-319-27111-8_9

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