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Olanzapine for the Prevention of Chemotherapy-Induced Nausea and Vomiting

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Management of Chemotherapy-Induced Nausea and Vomiting

Abstract

Chemotherapy-induced nausea and vomiting (CINV) is associated with a significant deterioration in quality of life and is perceived by patients as a major adverse effect of the treatment [1]. The use of 5-hydroxytryptamine-3 (5-HT3) receptor antagonists plus dexamethasone has significantly improved the control of CINV [2]. Recent studies have demonstrated additional improvement in the control of CINV with the use of new agents: palonosetron, a second generation 5-HT3 receptor antagonist [3]; NK-1 receptor antagonists aprepitant, netupitant, and rolapitant [4–6]; and olanzapine, an antipsychotic which blocks multiple neurotransmitters in the central nervous system [7–9].

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Authors and Affiliations

  1. Cancer Care Program, Central and South America, World Health Organization, Atlanta, USA

    Rudolph M. Navari MD, PhD, FACP

  2. Student Outreach Clinic, Indiana University School of Medicine South Bend, South Bend, IN, USA

    Rudolph M. Navari MD, PhD, FACP

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  1. Rudolph M. Navari MD, PhD, FACP
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Correspondence to Rudolph M. Navari MD, PhD, FACP .

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  1. Indiana University School of Medicine, South Bend, Indiana, USA

    Rudolph M. Navari

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Navari, R.M. (2016). Olanzapine for the Prevention of Chemotherapy-Induced Nausea and Vomiting. In: Navari, R. (eds) Management of Chemotherapy-Induced Nausea and Vomiting. Adis, Cham. https://doi.org/10.1007/978-3-319-27016-6_6

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  • DOI: https://doi.org/10.1007/978-3-319-27016-6_6

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  • Publisher Name: Adis, Cham

  • Print ISBN: 978-3-319-27014-2

  • Online ISBN: 978-3-319-27016-6

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