Abstract
This chapter is an up-to-date review of psychophysical means for testing the human sense of smell. Strengths and weaknesses of major psychophysical paradigms are discussed, including ones associated with the measurement of odor detection, discrimination, identification, memory and both suprathreshold intensity and pleasantness assessment. Factors that influence olfactory test results are discussed in detail, including the influences of test parameters, such as test length, on test reliability. It is pointed out that non-forced-choice tests, unlike forced–choice tests, are incapable of discerning subject biases and malingering. Issues related to the comparison and interpretation of test results from nominally disparate tests that differ in sensitivity, reliability, operational demands, and other factors are discussed.
Keywords
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- 2-D:
-
two-dimensional
- 3-D:
-
three-dimensional
- JND:
-
just noticeable difference
- UPSIT:
-
University of Pennsylvania smell identification test
References
E.H. Weber: De Pulsu, Resorptione, Auditu et Tactu: Annotationes Anatomicae et Physiologiae (Koehler, Leipzig 1834)
G.T. Fechner: Elemente der Psychophysik (Breitkopf and Harterl, Leipzig 1860)
L.L. Thurstone: A law of comparative judgment, Psychol Rev. 34, 273–286 (1927)
S.S. Stevens: To honor Fechner and repeal his law – A power function, not a log function, describes operating characteristic of a sensory system, Science 133, 80–84 (1961)
D.R. Peryam, P.J. Pilgrim: Hedonic scale method for measuring food preferences, Food Technol. 11, 9–14 (1957)
E.G. Boring: Sensation and Perception in the History of Experimental Psychology (Appleton-Century-Crofts, New York 1942)
R.L. Doty: Introduction and historical perspective. In: Handbook of Olfaction and Gustation, ed. by R.L. Doty (Marcel Dekker, New York 2003) pp. xv–xlv
G. Ekman, L. Sjoeberg: Scaling, Annu. Rev. Psychol. 16, 451–474 (1965)
T. Engen: The Perception of Odors (Academic Press, New York 1982)
G.A. Gescheider: Psychophysics: Method and Theory (Lawrence Erlbaum, Hillsdale 1976)
J.P. Guilford: Psychometric Methods (McGraw-Hill, New York 1954)
E.P. Koster: Human psychophysics in olfaction. In: Methods in Olfactory Research, ed. by D.G. Moulton, A. Turk, J.W. Johnston Jr. (Academic, London 1975) pp. 345–374
L.E. Marks: Sensory Processes (Academic, New York 1974)
D.J. Murray: A perspective for viewing the history of psychophysics, Behav. Brain Sci. 16, 115–186 (1993)
W.P. Tanner Jr., J.A. Swets: A decision-making theory of visual detection, Psychol. Rev. 61, 401–409 (1954)
E. von Skramlik: Handbuch der Physiologie der Niederen Sinne (Georg Thieme, Leipzig 1926)
H. Zwaardemaker: Die Physiologie des Geruchs (W. Engelmann, Leipzig 1895)
H.T. Lawless, H. Heymann: Sensory Evaluation of Food: Principles and Practice (Springer, New York 2010)
H. Zwaardemaker: On measurement of the sense of smell in clinical examination, Lancet I, 1300–1302 (1889)
R.L. Doty, T.P. Gregor, R.G. Settle: Influence of intertrial interval and sniff-bottle volume on phenyl ethyl alcohol odor detection thresholds, Chem. Senses 11, 259–264 (1986)
R.A. Frank, M.F. Dulay, R.C. Gesteland: Assessment of the sniff magnitude test as a clinical test of olfactory function, Physiol. Behavior. 78, 195–204 (2003)
S. Nordin, A. Bramerson, E. Liden, M. Bende: The Scandinavian odor-identification test: Development, reliability, validity and normative data, Acta Otolaryngol. 118, 226–234 (1998)
G.H. Cheesman, M.J. Townsend: Further experiments on the olfactory thresholds of pure chemical substances using the sniff-bottle method, Quart. J. Exp. Psychol. 8, 8–14 (1956)
M. Samochocki, A. Hoffle, A. Fehrenbacher, R. Jostock, J. Ludwig, C. Christner, M. Radina, M. Zerlin, C. Ullmer, E.F. Pereira, H. Lubbert, E.X. Albuquerque, A. Maelicke: Galantamine is an allosterically potentiating ligand of neuronal nicotinic but not of muscarinic acetylcholine receptors, J. Pharmacol. Exp. Ther. 305, 1024–1036 (2003)
F.N. Jones: The reliability of olfactory thresholds obtained by sniffing, Am. J. Psychol. 68, 289–290 (1955)
H.S. Koelega: Olfaction and sensory asymmetry, Chem. Senses Flav. 4, 89–95 (1979)
P. Green, G. Iverson: Exaggeration of anosmia in 80 litigating head injury cases, Arch. Clin. Neuropsychol. 13, 138 (1998)
S. Saito, S. Ayabe-Kanamura, Y. Takashima, N. Gotow, N. Naito, T. Nozawa, M. Mise, Y. Deguchi, T. Kobayakawa: Development of a smell identification test using a novel stick-type odor presentation kit, Chem. Senses 31, 379–391 (2006)
G. Semb: The detectability of the odor of butanol, Percept. Psychophys. 4, 335–340 (1968)
B. Toyota, T. Kitamura, S.F. Takagi: Olfactory Disorders – Olfactometry and Therapy (Igaku-Shoin, Tokyo 1978)
T.M. Davidson, C. Murphy: Rapid clinical evaluation of anosmia. The alcohol sniff test, Arch. Otolaryngol. Head Neck Surg. 123, 591–594 (1997)
T. Hummel, B. Sekinger, S.R. Wolf, E. Pauli, G. Kobal: Sniffin sticks: Olfactory performance assessed by the combined testing of odor identification, odor discrimination and olfactory threshold, Chem. Senses 22, 39–52 (1997)
H.R. Briner, D. Simmen: Smell diskettes as screening test of olfaction, Rhinology 37, 145–148 (1999)
J.E. Amoore, B.G. Ollman: Practical test kits for quantitatively evaluating the sense of smell, Rhinology 21, 49–54 (1983)
W.S. Cain, J.F. Gent, R.B. Goodspeed, G. Leonard: Evaluation of olfactory dysfunction in the Connecticut chemosensory clinical research center, Laryngoscope 98, 83–88 (1988)
R.L. Doty: Odor Threshold Test Administration Manual (Sensonics, Haddon Hts., NJ 2000)
D.G. Guadagni, R.G. Buttery, S. Okano: Odour thresholds of some organic compounds associated with food flavours, J. Food Sci. Agri. 14, 761–765 (1963)
S. Nordin, A. Bramerson, E. Liden, M. Bende: The Scandinavian odor-identification test: Development, reliability, validity and normative data, Acta Otolaryngol. 118, 226–234 (1999)
C.A. Elsberg, I. Levy: The sense of smell: I. A new and simple method of quantitative olfactometry, Bull. Neurol. Inst. 4, 5–19 (1935), N.Y.
K. Ikeda, K. Tabata, T. Oshima, H. Nishikawa, H. Hidaka, T. Takasaka: Unilateral examination of olfactory threshold using the jet stream olfactometer, Auris Nasus Larynx 26, 435–439 (1999)
E.L. Cameron, R.L. Doty: Odor identification testing in children and young adults using the smell wheel, Int. J. Pediatr. Otorhinolaryngol. 77, 346–350 (2013)
R.L. Doty, P. Shaman, M. Dann: Development of the University of Pennsylvania smell identification test: A standardized microencapsulated test of olfactory function, Physiol. Behav. 32, 489–502 (1984)
R.L. Doty: The Smell Identification Test Administration Manual – 3rd Edition (Sensonics, Haddon Hts., NJ 1995)
H. Fujio, K. Doi, S. Hasegawa, T. Kobayakawa, K. Nibu: Evaluation of card-type odor identification test for Japanese patients with olfactory disturbance, Ann. Otol. Rhinol. Laryngol. 121, 413–418 (2012)
R.L. Doty, D.A. Deems, R.E. Frye, R. Pelberg, A. Shapiro: Olfactory sensitivity, nasal resistance and autonomic function in patients with multiple chemical sensitivities, Arch. Otolaryngol. Head Neck Surg. 114, 1422–1427 (1988)
K. Springer: Combustion odors – A case study. In: Human Responses to Environmental Odors, ed. by A. Turk, J.W. Johnston Jr., D.G. Moulton (Academic Press, New York 1974) pp. 227–262
J.D. Prah, S.B. Sears, J.C. Walker: Modern approaches to air dilution olfactometry. In: Handbook of Olfaction and Gustation, ed. by R.L. Doty (Marcel Dekker, New York 1995) pp. 227–255
G. Kobal, K.H. Plattig: Objective olfactometry: Methodological annotations for recording olfactory EEG-responses from the awake human, EEG EMG Z. Elektroenzephalogr. Elektromyogr. Verwandte. Geb. 9, 135–145 (1978)
B.N. Johnson, N. Sobel: Methods for building an olfactometer with known concentration outcomes, J. Neurosci. Meth. 160, 231–245 (2007)
T.S. Lorig, D.G. Elmes, D.H. Zald, J.V. Pardo: A computer-controlled olfactometer for fMRI and electrophysiological studies of olfaction, Behav. Res. Meth. Instr. Comp. 31, 370–375 (1999)
P.H. Punter: Measurement of human olfactory thresholds for several groups of structurally related compounds, Chem. Senses 7, 215–235 (1983)
R. Schmidt, W.S. Cain: Making scents: Dynamic olfactometry for threshold measurement, Chem. Senses 35, 109–120 (2010)
J.C. Walker, D.B. Kurtz, F.M. Shore, M.W. Ogden, J.H. Reynolds: Apparatus for the automated measurement of the responses of humans to odorants, Chem. Senses 15, 165–177 (1990)
B.M. Wenzel: Techniques in olfactometry: A critical review of the last one hundred years, Psychol. Bull. 45, 231–247 (1948)
B. Berglund, L. Hoegman, M. Olsson: The Combined Effect of Formaldehyde and Radiant Heat on Odor Intensity and Sensory Irritation, Reports from the Department of Psychology, Vol. 681 (University of Stockholm, Stockholm 1988)
P. Dalton, C.J. Wysocki, M.J. Brody, H.J. Lawley: The influence of cognitive bias on the perceived odor, irritation and health symptoms from chemical exposure, Int. Arch. Occup. Environ. Health 69, 407–417 (1997)
H.R. Blackwell: Psychophysical Thresholds: Experimental Studies of Methods of Measurement (University of Michigan Press, Ann Arbor 1953)
R.L. Doty: Olfactory psychophysics. In: Chemistry of Taste: Mechanisms, Behaviors and Mimics, ed. by P. Given, D. Paredes (American Chemical Society, Washington 2003) pp. 123–139
R.L. Doty: Intranasal trigeminal detection of chemical vapors by humans, Physiol. Behav. 14, 855–859 (1975)
T.N. Cornsweet: The staircase-method in psychophysics, Am. J. Psychol. 75, 485–491 (1962)
R.M. Pangborn, H.W. Berg, E.B. Roessler, A.D. Webb: Influence of methodology on olfactory response, Percept. Mot. Skills 18, 91–103 (1964)
R.L. Doty, J.M. Diez, S. Turnacioglu, D.A. McKeown, J. Gledhill, K. Armstrong, W.W. Lee: Influences of feedback and ascending and descending trial presentations on perithreshold odor detection performance, Chem. Senses 28, 523–526 (2003)
Sensonics, Inc.: http://www.sensonics.com
J.D. Pierce Jr., R.L. Doty, J.E. Amoore: Analysis of position of trial sequence and type of diluent on the detection threshold for phenyl ethyl alcohol using a single staircase method, Percept. Mot. Skills 82, 451–458 (1996)
T. Tsukatani, T. Miwa, M. Furukawa, R.M. Costanzo: Detection thresholds for phenyl ethyl alcohol using serial dilutions in different solvents, Chem. Senses 28, 25–32 (2003)
K.S. Brown, C.M. MacLean, R.R. Robinette: The distribution of the sensitivity to chemical odors in man, Human Biol. 40, 456–472 (1968)
J.C. Stevens, W.S. Cain, R.J. Burke: Variability of olfactory thresholds, Chem. Senses 13, 643–653 (1988)
M. Yoshida: Correlation analysis of detection threshold data for standard test odors, Bull. Fac. Sci. Eng. Cho. Univ. 27, 343–353 (1984)
R.L. Doty, D.A. McKeown, W.W. Lee, P. Shaman: A study of the test-retest reliability of ten olfactory tests, Chem. Senses 20, 645–656 (1995)
R.L. Doty: Olfactory system. In: Smell and Taste in Health and Disease, ed. by T.V. Getchell, R.L. Doty, L.M. Bartoshuk, J.B. Snow Jr. (Raven Press, New York 1991) pp. 175–203
E.A. Gamble: The applicability of Weber’s law to smell, Am. J. Psychol. 39, 169–200 (1898)
J. Hermanides: Over de Constanten der in de Olfactometrie Gebruiklijke negen Standaardgeuren (Oosthoek, Utrecht 1909) pp. 58–59
M.J. Zigler, A.H. Holoway: Differential sensitivity as determined by the amount of olfactory substance, J. Gen. Psychol. 12, 372–382 (1935)
H. Stone, J.J. Bosley: Olfactory discrimination and Weber’s Law, Percept. Mot. Skills 20, 657–665 (1965)
B.M. Slotnick, J.E. Ptak: Olfactory intensity-difference thresholds in rats and humans, Physiol. Behav. 19, 795–802 (1977)
W.S. Cain: Differential sensitivity for smell: Noise at the nose, Science 195, 796–798 (1977)
W.S. Cain: Odor magnitude–coarse versus fine-grain, Percept. Psychophys. 22, 545–549 (1977)
R.L. Doty: In: Mammalian Olfaction, Reproductive Processes and Behavior, ed. by R.L. Doty (Academic Press, New York 1976)
R.L. Doty, P.J. Snyder, G.R. Huggins, L.D. Lowry: Endocrine, cardiovascular and psychological correlates of olfactory sensitivity changes during the human menstrual cycle, J. Comp. Physiol. Psychol. 95, 45–60 (1981)
J. Brown: Recognition assessed by rating and ranking, Br. J. Psychol. 65, 13–22 (1974)
P.W. Frey, J.A. Colliver: Sensitivity and responsivity measures for discrimination learning, Learning and Motivation 4, 327–342 (1973)
M. O’Mahony, L. Gardner, D. Long, C. Heintz, B. Thompson, M. Davies: Salt taste detection: An R-index approach to signal-detection measurements, Perception 8, 497–506 (1979)
J.B. Grier: Nonparametric indexes for sensitivity and bias–computing formulas, Psychol. Bull. 75, 424–429 (1971)
W. Hodos: Nonparametric index of response bias for use in detection and recognition experiments, Psychol. Bull. 74, 351–354 (1970)
N.A. Macmillan, C.D. Creelman: Triangles in ROC space: History and theory of nonparametric measures of sensitivity and response bias, Psychonomic Bull. Rev. 3, 164–170 (1996)
H. Potter, N. Butters: An assessment of olfactory deficits in patients with damage to prefrontal cortex, Neuropsychologia 18, 621–628 (1980)
H. Eichenbaum, T.H. Morton, H. Potter, S. Corkin: Selective olfactory deficits in case H.M, Brain 106, 459–472 (1983)
M. O’Mahony: Short-cut signal detection measures for sensory analysis, J. Food Sci. 44, 302–303 (1979)
C.K. Rovee, R.Y. Cohen, W. Shlapack: Life-span stability in olfactory sensitivity, Dev. Psychol. 11, 311–318 (1975)
R.L. Doty, R. Smith, D.A. McKeown, J. Raj: Tests of human olfactory function: Principal components analysis suggests that most measure a common source of variance, Percept. Psychophys. 56, 701–707 (1994)
P. McReynolds, K. Ludwig: On the history of rating scales, Personal. Individ. Diff. 8, 281–283 (1987)
P.T. Young: Constancy of affective judgment to odors, J. Exp. Psychol. 6, 182–191 (1923)
L.M. Bartoshuk, K. Fast, D.J. Snyder: Differences in our sensory–Invalid comparisons with labeled scales, Curr. Dir. Psychol. Sci. 14, 122–125 (2005)
G. Borg: A category scale with ratio properties for intermodal and interindividual comparisons. In: Psychophysical Judgment and the Process of Perception, ed. by H.G. Geissler, P. Penzold (VEG Deutscher Verlag Der Wissenschaften, Berlin 1982) pp. 25–34
G. Neely, G. Ljunggren, C. Sylven, G. Borg: Comparison between the visual analogue scale (VAS) and the category ratio scale (CR-10) for the evaluation of leg exertion, Int. J. Sport. Med. 13, 133–136 (1992)
B.G. Green, P. Dalton, B. Cowart, G. Shaffer, K. Rankin, J. Higgins: Evaluating the Labeled Magnitude Scale for measuring sensations of taste and smell, Chem. Senses 21, 323–334 (1996)
S.S. Stevens, E.H. Galanter: Ratio scales and category scales for a dozen perceptual continua, J. Exp. Psychol. 54, 377–411 (1957)
N.H. Anderson: Functional measurement and psychophysical judgment, Psychol Rev. 77, 153–170 (1970)
M.J. Hjermstad, P.M. Fayers, D.F. Haugen, A. Caraceni, G.W. Hanks, J.H. Loge, R. Fainsinger, N. Aass, S. Kaasa: Studies comparing numerical rating scales, verbal rating scales and visual analogue scales for assessment of pain intensity in adults: A systematic literature review, J. Pain Symptom Manage. 41, 1073–1093 (2011)
C.C. Preston, A.M. Colman: Optimal number of response categories in rating scales: Reliability, validity, discriminating power and respondent preferences, Acta Psychol. 104, 1–15 (2000)
R.L. Doty: An examination of relationships between the pleasantness, intensity and concentration of 10 odorous stimuli, Percept. Psychophys. 17, 492–496 (1975)
R.L. Doty: An examination of relationships between the pleasantness, intensity, and concentration of 10 odorous stimuli, Percept. Psychophys. 17, 492–496 (1975)
F.N. Jones: Subjective scales of intensity for the three odors, Am. J. Psychol. 71, 423–425 (1958)
P. Overbosch: A theoretical model for perceived intensity in human taste and smell as a function of time, Chem. Senses 11, 315–329 (1986)
H.T. Lawless, G.T. Malone: A comparison of rating scales: Sensitivity, replicates and relative measurement, J. Sensory Studies 1, 155–174 (1986)
H.T. Lawless, G.T. Malone: The discrimination efficiency of common scaling methods, J. Sensory Studies 1, 85–98 (1986)
J.C. Baird, C. Lewis, D. Romer: Relative frequencies of numerical responses in ratio estimation, Percept. Psychophys. 8, 358–362 (1970)
H.R. Moskowitz: Magnitude estimation: Notes on what, how, when and why to use it, J. Food Quality 3, 195–227 (1977)
H. Helson: Adaptation-Level Theory: An Experimental and Systematic Approach to Behavior (Harper and Row, New York 1964)
R.K. Eyman, P.J. Kim, T. Call: Judgment error in category versus magnitude scales, Percept. Mot. Skills 40, 415–423 (1975)
A.L. Myers: Psychophysical scaling and scales of physical stimulus measurement, Psychol. Bull. 92, 203–214 (1982)
F.N. Jones, M.J. Woskow: Some effects of context on the slope in magnitude estimation, J. Exp. Psychol. 71, 177–180 (1966)
L.E. Marks, J.C. Stevens, L.M. Bartoshuk, J.F. Gent, B. Rifkin, V.K. Stone: Magnitude-matching: The measurement of taste and smell, Chem. Senses 13, 63–87 (1988)
L.E. Marks, R. Szczesiul, P. Ohlott: On the cross-modal perception of intensity, J. Exp. Psychol.: Hum. Percept. Perform. 12, 517–534 (1986)
H. Eisler: How prothetic is the continuum of smell? A further comment on the relation between magnitude and category scales, Scand. J. Psychol. 10, 89–96 (1962)
R.L. Doty: On the protheticity of olfactory pleasantness and intensity, Percept. Mot. Skills 85, 1439–1449 (1997)
J.E. Frijters: Three-stimulus procedures in olfactory psychophysics: An experimental comparison of Thurstone-Ura and three-alternative forced-choice models of signal detection theory, Percept. Psychophys. 28, 390–397 (1980)
E.S. Choudhury, P. Moberg, R.L. Doty: Influences of age and sex on a microencapsulated odor memory test, Chem. Senses 28, 799–805 (2003)
R. Weierstall, B.M. Pause: Development of a 15-item odour discrimination test (Dusseldorf Odour Discrimination Test), Perception 41, 193–203 (2012)
S.S. Schiffman, M.L. Reynolds, F.W. Young: Introduction to Multidimensional Scaling: Theory, Methods, and Applications (Academic Press, Orlando 1981)
M. Carrasco, J.B. Ridout: Olfactory perception and olfactory imagery: A multidimensional analysis, J. Exp. Psychol.: Hum. Percept. Perform. 19, 287–301 (1993)
Y. Ueno: Perception of odor quality by Free Image-Association Test, Shinrigaku Kenkyu 63, 256–261 (1992)
A. Abraham, K.V. Mathai: The effect of right temporal lobe lesions on matching of smells, Neuropsychologia 21, 277–281 (1983)
D. Sumner: On testing the sense of smell, Lancet 2, 895–897 (1962)
R.A. Gregson, D.A. Smith: The clinical assessment of olfaction: Differential diagnoses including Kallman’s syndrome, J. Psychosom. Res. 25, 165–174 (1981)
W.S. Cain, J. Gent, F.A. Catalanotto, R.B. Goodspeed: Clinical evaluation of olfaction, Am. J. Otolaryngol. 4, 252–256 (1983)
R.L. Doty, A. Marcus, W.W. Lee: Development of the 12-item cross-cultural smell identification test (CC-SIT), Laryngoscope 106, 353–356 (1996)
A.H. Jackman, R.L. Doty: Utility of a three-item smell identification test in detecting olfactory dysfunction, Laryngoscope 115, 2209–2212 (2005)
J.B. Wood, S.W. Harkins: Effects of age, stimulus selection, and retrieval environment on odor identification, J. Gerontol. 42, 584–588 (1987)
H.N. Wright: Characterization of olfactory dysfunction, Arch. Otolaryngol. Head Neck Surg. 113, 163–168 (1987)
W.S. Cain, R.D. Rabin: Comparability of two tests of olfactory function, Chem. Senses 14, 479–485 (1989)
M. Larsson: Semantic factors in episodic recognition of common odors in early and late adulthood: A review, Chem. Senses 22, 623–633 (1997)
Y. Yeshurun, Y. Dudai, N. Sobel: Working memory across nostrils, Behav. Neurosci. 122, 1031–1037 (2008)
S.M. Bromley, R.L. Doty: Odor recognition memory is better under bilateral than unilateral test conditions, Cortex 31, 25–40 (1995)
T. Engen, J.E. Kuisma, P.D. Eimas: Short-term memory of odors, J. Exp. Psychol. 99, 222–225 (1973)
A.J. Johnson, C. Miles: Single-probe serial position recall: Evidence of modularity for olfactory, visual, and auditory short-term memory, Quart. J. Exp. Psychol. 62, 267–275 (2009)
B.P. Jones, R.H. Moskowitz, N. Butters: Olfactory discrimination in alcoholic Korsakoff patients, Neuropsychol. 13, 173–179 (1975)
S.J. Patel, A. Bollhoefer, R.L. Doty: Influences of ethanol ingestion on olfactory function in humans, Psychopharmacology 171, 4290434 (2004)
M. Jones-Gotman, R.J. Zatorre: Odor recognition memory in humans: Role of right temporal and orbitofrontal regions, Brain Cogn. 22, 182–198 (1993)
J.M. Campbell, R.A.M. Gregson: Olfactory short term memory in normal, schizophrenic and brain-damaged cases, Austral. J. Psychol. 24, 179–185 (1972)
R.A. Gregson, M.L. Free, M.W. Abbott: Olfaction in Korsakoffs, alcoholics and normals, Br. J. Clin. Psychol. 20, 3–10 (1981)
E.E. Morrison, R.M. Costanzo: Morphology of the human olfactory epithelium, J. Comp. Neurol. 297, 1–13 (1990)
R. Naessen: An enquiry on the morphological characteristics and possible changes with age in the olfactory region of man, Acta Oto-Laryngol. 71, 49–62 (1971)
T. Nakashima, C.P. Kimmelman, J.B. Snow Jr.: Structure of human fetal and adult olfactory neuroepithelium, Arch. Otolaryngol. 110, 641–646 (1984)
S.I. Paik, M.N. Lehman, A.M. Seiden, H.J. Duncan, D.V. Smith: Human olfactory biopsy. The influence of age and receptor distribution, Arch. Otolaryngol. Head Neck Surg. 118, 731–738 (1992)
L.J. Chapman, J.P. Chapman: Problems in the measurement of cognitive deficit, Psychol. Bull. 79, 380–385 (1973)
T. Vollmecke, R.L. Doty: Development of the Picture Identification Test (PIT): A research companion to the University of Pennsylvania Smell Identification Test, Chem. Senses 10, 413–414 (1985)
R.L. Doty, M.B. Stern, C. Pfeiffer, S.M. Gollomp, H.I. Hurtig: Bilateral olfactory dysfunction in early stage treated and untreated idiopathic Parkinson’s disease, J. Neurol. Neurosurg. Psychiat. 55, 138–142 (1992)
S.A. Betchen, R.L. Doty: Bilateral detection thresholds in dextrals and sinistrals reflect the more sensitive side of the nose, which is not lateralized, Chem. Senses 23, 453–457 (1998)
V. Gudziol, C. Hummel, S. Negoias, T. Ishimaru, T. Hummel: Lateralized differences in olfactory function, Laryngoscope 117, 808–811 (2007)
R.L. Doty, M. Kisat, I. Tourbier: Estrogen replacement therapy induces functional asymmetry on an odor memory/discrimination test, Brain Res. 1214, 35–39 (2008)
T. Engen: Effect of practice and instruction on olfactory thresholds, Percept. Mot. Skills 10, 195–198 (1960)
M.D. Rabin, W.S. Cain: Determinants of measured olfactory sensitivity, Percept. Psychophys. 39, 281–286 (1986)
C.J. Wysocki, K.M. Dorries, G.K. Beauchamp: Ability to perceive androstenone can be acquired by ostensibly anosmic people, Proc. Nat. Acad. Sci. 86, 7976–7978 (1989)
J.A. Desor, G.K. Beauchamp: The human capacity to transmit olfactory information, Percept. Psychophys. 16, 551–556 (1974)
T. Engen, B.M. Ross: Long-term memory of odors with and without verbal descriptions, J. Exp. Psychol. 100, 221–227 (1973)
W.S. Cain, F. Johnson Jr.: Lability of odor pleasantness: Influence of mere exposure, Percept. 7, 459–465 (1978)
J.E. Cometto-Muñiz, W.S. Cain: Olfactory adaptation. In: Handbook of Olfaction and Gustation, ed. by R.L. Doty (Marcel Dekker, New York 1995) pp. 257–281
S.C. Karnekull, F.U. Jonsson, M. Larsson, J.K. Olofsson: Affected by smells? Environmental chemical responsivity predicts odor perception, Chem. Senses 36, 641–648 (2011)
P. Dalton: Odor perception and beliefs about risk, Chem. Senses 21, 447–458 (1996)
P. Dalton: Cognitive influences on health symptoms from acute chemical exposure, Health Psychol. 18, 579–590 (1999)
G.M. Zucco, C. Militello, R.L. Doty: Discriminating between organic and psychological determinants of multiple chemical sensitivity: A case study, Neurocase 14, 485–493 (2008)
S. Nordin, M. Martinkauppi, J. Olofsson, T. Hummel, E. Millqvist, M. Bende: Chemosensory perception and event-related potentials in self-reported chemical hypersensitivity, Int. J. Psychophysiol. 55, 243–255 (2005)
T. Hummel, S. Roscher, M.P. Jaumann, G. Kobal: Intranasal chemoreception in patients with multiple chemical sensitivities: A double-blind investigation, Regul. Toxicol. Pharmacol. 24, S79–S86 (1996)
E. Caccappolo, H. Kipen, K. Kelly-McNeil, S. Knasko, R.M. Hamer, B. Natelson, N. Fiedler: Odor perception: Multiple chemical sensitivities, chronic fatigue, and asthma, J. Occupat. Environ. Medi. 42, 629–638 (2000)
R.L. Doty, B. Crastnopol: Correlates of chemosensory malingering, Laryngoscope 120, 707–711 (2010)
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The preparation of this chapter was supported, in part, by USAMRAA W81XWH-09-1-0467 from the Department of Defense.
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Doty, R.L. (2017). Psychophysical Testing of Human Olfactory Function. In: Buettner, A. (eds) Springer Handbook of Odor. Springer Handbooks. Springer, Cham. https://doi.org/10.1007/978-3-319-26932-0_23
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DOI: https://doi.org/10.1007/978-3-319-26932-0_23
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-26930-6
Online ISBN: 978-3-319-26932-0
eBook Packages: Chemistry and Materials ScienceChemistry and Material Science (R0)