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Microsystems for Emulsification

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Abstract

Emulsions are important pharmaceutical preparations that are traditionally prepared by techniques like high-shear mixing and high-pressure homogenization. In recent years, microstructured devices have attained increasing importance with regard to emulsion preparation. In particular, the possibility of preparing emulsions with very precisely controlled particle size distribution and/or of continuous manufacturing makes such devices interesting. This chapter introduces microsystem-based techniques operating at low to moderate pressure and high-pressure-based methods. The former comprise direct microchannel and membrane emulsification as well as premix membrane emulsification. The latter particularly focuses on emulsification in a customized microchannel system but also covers aspects of conventional high-pressure emulsification devices. Apart from explaining the respective principles and devices, their use for the preparation of pharmaceutical formulations is outlined.

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Authors and Affiliations

  1. Institut für Pharmazeutische Technologie, Technische Universität Braunschweig, Mendelssohnstr. 1, Braunschweig, 38106, Germany

    H. Bunjes & C. C. Müller-Goymann

  2. PVZ—Center of Pharmaceutical Engineering, Technische Universität Braunschweig, Franz-Liszt-Str. 35 A, Braunschweig, 38106, Germany

    H. Bunjes & C. C. Müller-Goymann

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  1. H. Bunjes
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Correspondence to H. Bunjes .

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  1. Institute of Microtechnology, Technische Universität Braunschweig, Braunschweig, Germany

    Andreas Dietzel

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Bunjes, H., Müller-Goymann, C.C. (2016). Microsystems for Emulsification. In: Dietzel, A. (eds) Microsystems for Pharmatechnology. Springer, Cham. https://doi.org/10.1007/978-3-319-26920-7_5

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