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Smart Stimuli-Responsive Nano-sized Hosts for Drug Delivery

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Industrial Applications for Intelligent Polymers and Coatings

Abstract

The evolution in the synthesis of smart polymers broadens new horizons for their potent application in medicine, especially in drug delivery. Many synthetic polymers that exhibit environmentally responsive behavior are potential smart carrier candidates that allow for controlled therapeutic delivery. These materials can be loaded with specific drugs for therapeutic applications, releasing treatment in response to a stimulus. This stimuli-responsive capability has enabled smart polymeric materials to distribute drugs in response to commonly known exogenous and/or endogenous stimuli. Examples of these various stimuli include pH, enzyme concentration, temperature, ultrasound intensity, as well as light, magnetic field, redox gradients and a multitude of other potential stimuli. This chapter provides a detailed critical discussion and an overview of the stimuli-responsive polymers which have found applications in targeted drug delivery. Furthermore, multiresponsive systems and their forthcoming development as well as challenges associated with some stimuli-responsive systems are discussed. Finally, the most recent and emerging trends along with a look toward expected future breakthroughs using these types of nanocarriers are discussed.

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Acknowledgement

The authors would like to thank Ms. Zahra Bagheri Nezhad from Raykasoft Inc., for her assistant with designing Figs. 1.1 and 1.6.

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Authors and Affiliations

  1. Manufacturing and Industrial Engineering Department, College of Engineering and Computer Science, The University of Texas – Rio Grande Valley, Edinburg, TX, USA

    Majid Hosseini & Abdel Salam Hamdy Makhlouf

  2. Pharmaceutical Sciences Research Center, School of Pharmacy, Shiraz University of Medical Sciences, 71345-1583, Shiraz, Iran

    Fatemeh Farjadian

Authors
  1. Majid Hosseini
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  2. Fatemeh Farjadian
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  3. Abdel Salam Hamdy Makhlouf
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Correspondence to Majid Hosseini , Fatemeh Farjadian or Abdel Salam Hamdy Makhlouf .

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Editors and Affiliations

  1. College of Engineering and Computer Scie, Manufacturing and Industrial Engineering, Edinburg, Texas, USA

    Majid Hosseini

  2. College of Eng. & Computer Science, RGV Star Professor, Manufacturing and In, Edinburg, Texas, USA

    Abdel Salam Hamdy Makhlouf

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Hosseini, M., Farjadian, F., Makhlouf, A.S.H. (2016). Smart Stimuli-Responsive Nano-sized Hosts for Drug Delivery. In: Hosseini, M., Makhlouf, A. (eds) Industrial Applications for Intelligent Polymers and Coatings. Springer, Cham. https://doi.org/10.1007/978-3-319-26893-4_1

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