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HIV-Associated Hodgkin Lymphoma

  • Marcus HentrichEmail author
  • Michele Spina
  • Silvia Montoto
Chapter

Abstract

Hodgkin lymphoma (HL) is one of the most common non-AIDS-defining malignancies in patients infected with HIV. Unfavorable features such as higher frequency of advanced-stage disease and extranodal involvement are frequently encountered. Prior to the advent of combined antiretroviral therapy (cART), the prognosis of patients with HIV-HL was poor. However, with standard curative-intent therapy and modern cART, the outcome is similar to that reported in the general population. In patients with early favorable HL two cycles of ABVD followed by involved-field radiation (IF-RT) is considered standard of care. Patients with early unfavorable HL should receive four cycles of ABVD + IF-RT while six cycles of ABVD or six cycles of BEACOPP baseline should be given to patients with advanced HIV-HL.

Keywords

Overall Survival Hodgkin Lymphoma Autologous Stem Cell Transplantation Immune Reconstitution Inflammatory Syndrome Brentuximab Vedotin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer International Publishing Switzerland 2016

Authors and Affiliations

  • Marcus Hentrich
    • 1
    Email author
  • Michele Spina
    • 2
  • Silvia Montoto
    • 3
  1. 1.Department of Hematology and OncologyRed Cross Hospital, University of MunichMunichGermany
  2. 2.Division of Medical Oncology ANational Cancer InstituteAvianoItaly
  3. 3.Centre for Haemato-OncologySt Bartholomew’s Hospital, Barts Cancer Institute, Queen Mary University of LondonLondonUK

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